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| 1 | Vitamin D for the prevention and treatment of pancreatic cancer显示文摘Pancreatic cancer is ranked fi fth among cancer-related deaths worldwide with a 5-year survival rate of less than 5%. Currently, surgery is the only effective therapy. However, most patients are diagnosed in the late stage and are not suitable for receiving curative surgery. Moreover, pancreatic cancer doesn't respond well to traditional chemotherapy and radiotherapy, leaving little effective treatment for advanced pancreatic cancer cases. 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], the biologically active form of vitamin D3, was originally identifi ed during studies of calcium and bone metabolism, though it is now recognized that it exerts biological effects in almost every tissue in the body. Abundant evidence has shown that 1α,25(OH)2D3 has antiproliferative, apoptotic, pro-differentiation and antiangiogensis effects in many types of cancer cells in vivo and in vitro, including breast, prostate, and colon. Similarly, the antitumor growth effect of 1α,25(OH)2D3 on pancreatic cells has been demonstrated. The clinical use of 1α,25(OH)2D3 is impeded by the lethal side effects of hypercalcemia and hypercalciuria. Therefore, 1α,25(OH)2D3 analogs, which are either equipotent or more potent than 1α,25(OH)2D3 in inhibiting tumor cell growth but with fewer hypercalcemic and hypercalciuric side effects, have been developed for the treatment of different cancers. Recently, a pre-clinical study demonstrated that a less calcemic analog of 1α,25(OH)2D3, 19-nor-1α,25(OH)2D2 (Paricalcitol), is effective in inhibiting tumor growth in vitro and in vivo , via upregulation of p21 and p27 tumor suppressor genes. Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway.1α,25(OH)2D3 and its analogs are potentially attractive novel therapies for pancreatic cancer. | Kun-Chun Chiang Tai C Chen | 2009 | World Journal of Gastroenterology2009，15，27： | 7 |
| 2 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 3 | A binary level set model and some applications to mumford-shah image segmentation 显示文摘 | L/E J LYSAKER M TAI X C | 2006 | IEEE Transactions on Image Processing2006，15，1： | 1 |
| 4 | A morphological and structural study of uhem/P84 copolyimide dual-layer hollow fiber membranes with delamination-free morpho/ogy 显示文摘 | Natalia W Tai S C William B | 2007 | Journal of Membrane Science ( S1006-2289 )2007，294，： | 1 |
| 5 | A mesh reconstruction algorithm driven by an intrinsic property of a point cloud显示文摘 | Lin H W Tai C L Wang G J | 2004 | Computer-Aided Design2004，36，1： | 1 |
| 6 | Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular carcinoma (HCC) and adverse outcome of HCC patients显示文摘 | TSENG P L TAI M H HUANG C C | 2008 | J Surg Oncol2008，98，5： | 1 |
| 7 | Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve显示文摘 | Tai C Roppolo JR de Groat WC | 2004 | Journal of Urology2004，172，： | 1 |
| 8 | Reversal of atrial electrical remodeling following cardioversion of long-standing atrial fibrillation in man显示文摘 | YU W C LEE S H TAI C T | 1999 | Cardiovasc Res1999，42，： | 1 |
| 9 | Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes? 显示文摘 | Sabanayagam C Liew G Tai ES | 2009 | I)iabetologia2009，52，7： | 1 |
| 10 | Handle- aware isolines for scalable shape editing显示文摘 | Au O K C Fu H B Tai C L | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 11 | Components of Hedyotis diffusa Wild显示文摘 | Tai D F Lin YM Chen F C | 1979 | Hua Hsueh1979，，3： | 1 |
| 12 | A mesh reconstruction algorithm driven by intrinsic property of point cloud 显示文摘 | Lin Hongwei Tai C L Wang Guojin | 2004 | Computer-Aided Design2004，36，1： | 1 |
| 13 | A comparison of performance of tetra-ploid progenies produced by diploid and their vegetativelydoubled(tetraploid) counterpart parents 显示文摘 | Tai G C C Dejong H | 1997 | Theor Appl Gen-et1997，94，： | 1 |
| 14 | A micro cell lysis device显示文摘 | Lee S W Tai Y C | | 0，，： | 1 |
| 15 | Adverse effects of arecoline and nicotine on human periodontal ligament fibroblasts in vitro 显示文摘 | CHANG Y C LII C K TAI K W | 2001 | J Clin Periodontol2001，28，3： | 1 |
| 16 | Recent advances in the homogeneous hydrogenation of carbon dioxide显示文摘 | Jessop P G Joo F Tai C C | 2004 | Coord Chem Rev2004，248，2124： | 1 |
| 17 | Titanium-alloy MEMS wing technology for a micro aerial vehicle application显示文摘 | Pornsin-sirirak T N Tai Y C Nassef H | 2001 | Sensors and Actuators A2001，89，： | 1 |
| 18 | Noise Removal Using Fourth-Order Partial Differential Equation with Applications to Medical Magnetic Resonance Images in Space and Time 显示文摘 | Lysaker M Lundervold A Tai X C | 2003 | IEEE Trans on Image Processing2003，12，12： | 1 |
| 19 | Randomized clinical trial of the effect of open versus laparoscopically assisted colectomy on systemic immunity in patients with colorectal cancer显示文摘 | TANG C L EU K W TAI B C | 2001 | Br J Surg2001，88，6： | 1 |
| 20 | An extension algoRithm for B-spline by curve unclamping显示文摘 | Hu Shimin Tai C L Zhang Songhai | 2002 | Computer-Aided Design2002，34，5： | 1 |
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