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	题名	作者	年代	出处	被引量
1	Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis.	Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács	2007	World Journal of Gastroenterology2007，13，33：	5
2	Preparation and characterization of fouling-resistant TiO2 selfassembled nanocomposite membranes 显示文摘	Bae T H Kim I C Tak T M	2006	Journal of Membrane Science2006，275，12：	1
3	1 Efficacy and toxici- ty of tom bination treatment with epirubicin(EPI)plus docetaxel (DOC) in advanced breast cancer显示文摘	Tak ahashiM WatanabeK T akahashiH eta	2006	Gan To Kagaku Ryoho2006，33，11：	1
4	The role of NF -kap- paB activation in the pathogenesis of acute pancreatitis 显示文摘	Rakonczay Z Jr Hegyi P Tak(zcs T	2008	Gut2008，57，2：	1
5	The impact of p53 and p73 on aneuploidy and cancer显示文摘	Richard T Tak W Gerry M	2008	Trends in Cell Biology2008，18，4：	1
6	The pathogenesis of L-arginine-induced acute necrotizing pancreatitis:inflammatory mediators and endogenous cholecystokinin显示文摘	Czakó L Takács T Varga IS	2000	J Physiol Paris2000，94，1：	1
7	Interpretation of fouling characteristics of ultrafihration membranes during the filtration of membrane bioreactor mixed liquor 显示文摘	BAE T H TAK T M	2005	Journal of Membrane Science2005，264，12：	1
8	Interpretation of fouling characteristics of uhrafihration membranes during the filtration of membrane bioreactor mixed liquor 显示文摘	Bae T H Tak T M	2005	Journal of Membrane Science2005，264，12：	1
9	Effect of TiOz nanoparticles on fouling mitigation of ultrafiltration membranes for activated sludge filtration显示文摘	BAE T H TAK T M	2005	Journal of Membrane Science2005，249，12：	1
10	Influence of sludge retention time on membrane fouling and bioactivities in mem- brane bioreactor system 显示文摘	Han S S Bae T H Jang G G Tak T M	2005	Process Biochemistry2005，407，：	1
11	PAMPA study of the temperature effect on permeability显示文摘	VIZSERLEK G BALOGH T TAKCS-NOVK K	2014	Eur J Pharm Sci2014，53，1：	1
12	Fouling control in activated sludge submerged hollow fiber membrane bioreactors显示文摘	Bae T H Tak T M	2002	Desalination2002，143，3：	1
13	Membrane sequencing batch reactor system for the treatment of dairy industry wastewater显示文摘	Bae T H Han S S Tak T M	2003	Process Biochemistry2003，39，2：	1
14	Optimal design of HY-PER target system based on the thermal andstructural analysis of Pb-Bi spallation target andbeam window 显示文摘	SONG T Y TAK N I	2003	Annals of Nuclear Energy2003，30，12：	1
15	Effects of galanin(1-16)on pancreatic secretion in anesthetized and conscious rats显示文摘	Takács T Hegyi P Czak6 L et al	2000	Res Exp Med2000，199，5：	1
16	Cardiac tamponade complicating myocardial infarction in the era of thrombolytics and platelet Ⅱb/Ⅲa:case report and literature review显示文摘	Mixon TA Tak T Lawrence ME	2001	Am J Geriatr Cardiol2001，10，3：	1
17	Efficacy and safety of sorafenib in patients in advanced hepatocellular carcinoma: Asia-Pacific trial subgroup by baseline transaminase/a-fetoprotein levels 显示文摘	QIN S YANG T TAK W	2009	J Clin Oncol2009，27，15：	1
18	Fouling control in activ- ated sludge submerged hollow fiber membrane bioreac- tor显示文摘	Hong S P Bae T H Tak T M etal	2002	Desalination2002，143，21：	1
19	Interpretation of fouling character- istics of ultraltration membranes during the filtration of membrane bioreactor mixed liquor 显示文摘	Bae T H Tak T M	2005	Membr Biol2005，264，：	1
20	Effect of loading conditions on Doppler derived transmittal flow indices in normal subjects and patients with coronary artery disease显示文摘	TAK T CHOUDHARY R S CHATTERJEE S	1992	Echocardiography1992，9，5：	1

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