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| 1 | Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease显示文摘AIM:To assess the long-term efficacy of seton drainage with infliximab maintenance therapy in treatment of stricture for perianal Crohn’s disease(CD). METHODS:Sixty-two patients with perianal CD who required surgical treatment with or without infliximab between September 2000 and April 2010 were identified from our clinic’s database.The activities of the perianal lesions were evaluated using the modified perianal CD activity index(mPDAI)score.The primary endpoint was a clinical response at 12-15 wk after surgery as a shortterm efficacy.Secondary endpoints were recurrence as reflected in the mPDAI score,defined as increased points in every major element.The clinical responses were classified as completely healed(mPDAI=0),partially improved(mPDAI score decreased more than 4 points),and failure or recurrence(mPDAI score increased or decreased less than 3 points). RESULTS:There were 43 males and 19 females,of whom 26 were consecutively treated with infliximab after surgery as maintenance therapy.Complete healing was not seen.Failure was seen in 10/36(27.8%) patients without infliximab and 4/26(15.4%)patients with infliximab(P=0.25).Partial improvement was seen in 26/36(72.2%)patients without infliximab and 22/26(88.5%)patients with infliximab(P=0.25). Short-term improvement was achieved in 48/62(77.4%) patients.Although the mPDAI score improved significantly with surgery regardless of infliximab,it decreased more from baseline in patients with infliximab(50.0%) than in those without infliximab(28.6%),(P=0.003). In the long-term,recurrence rates were low regardless of infliximab in patients without anorectal stricture.In patients with anorectal stricture,cumulative recurrence incidences increased gradually and exceeded 40%at 5 years regardless of infliximab.No efficacy of infliximab treatment was found(P=0.97).Although the cumulative rate of ostomy creation was also low in patients without stricture and high in patients with stricture,no protective efficacy was found with infliximab treatment(P =0.6 without stricture,P=0.22 with stricture). CONCLUSION:Infliximab treatment was demonstrated to have short-term efficacy for perianal lesions.Longterm benefit with infliximab was not proven,at least in patients with anorectal stricture. | Motoi Uchino Hiroki Ikeuchi Toshihiro Bando Hiroki Matsuoka Yoshio Takesue Yoshiko Takahashi Takayuki Matsumoto Naohiro Tomita | 2011 | World Journal of Gastroenterology2011，17，9： | 2 |
| 2 | Synthesis of polymeric microspheres employing SPG emulsification technique显示文摘 | Omi Shinzo Kaneko Kazuyoshi Takesue Mariko | 1994 | J Appl Polym Sci1994，51，7： | 1 |
| 3 | High-rate quantum key distribution over 100 km using ultra-low-noise, 2-GHz sinusoidally gated InGaAs/InP avalanche photodiodes 显示文摘 | N Namekata H Takesue T Honjo | 2011 | Opt Express2011，19，10： | 1 |
| 4 | Purification and characterization of intracellular α-L-rhamnosidase from Pseudomonas pancimobilis FP2001显示文摘 | MIAKE F SATHO T TAKESUE H | 2000 | Arch Microbiol2000，173，1： | 1 |
| 5 | Fast response MR-fluid actua-tor显示文摘 | Takesue N Furusho J | 2004 | JSME International Journal2004，47，3： | 1 |
| 6 | Development status of rotating machines employing superconducting field windings显示文摘 | KALSI S S WEEBER K TAKESUE H | 2004 | Proceedings of the IEEE2004，92，10： | 1 |
| 7 | A study of resistance to antiseptics of methicillin resistant Stapylococcus aureus (MRSA) in gastroenterological surgery 显示文摘 | Takesue Y Yokoyama T | 1991 | Nippon Geka Gakkai Zasshi1991，92，2： | 1 |
| 8 | Preoperative oral antibiotics and intravenous antimicrobial prophylaxis reduce the incidence of surgical site infections in patients with ulcerative colitis undergoing IPAA显示文摘 | Oshima T Takesue Y Ikeuchi H | 2013 | Diseases of the Colon and Rectum2013，56，10： | 1 |
| 9 | Mg/Ca, Sr/Ca, and stable isotopes in modern and holocene Protothaca staminea shells from a northern California coastal upwelling region显示文摘 | Takesue R K Van Geen A | 2004 | Geochimica Et Cosmochimica Acta2004，68，19： | 1 |
| 10 | Prediction for the development of postoperation infection in the operation of esophageal cancer compared with gastric surgery 显示文摘 | Takesue Y Yokoyama T Murakami Y | 1998 | Hirosima J Med Sci1998，47，3： | 1 |
| 11 | Risk factors associated with the development of thrombocytopenia in patients who received line- zolid therapy显示文摘 | Takahashi Y Takesue Y Nakajima K | 2011 | J Infect Chemother2011，17，3： | 1 |
| 12 | A single-dose regimen for antimicrobial prophylaxis to prevent perioperative infection in urological clean and clean-contaminated surgery显示文摘 | Higuchi Y Takesue Y Yamada Y | | 0，，2： | 1 |
| 13 | Long-term results of seton drainage on complex anal fistulae in patients with Crohn' s disease 显示文摘 | Takesue Y Ohge H Yokoyama T | 2002 | J Gastroenterol2002，37，11： | 1 |
| 14 | Factors influencing the development of small intestinal obstruction following total gastrectomy for gastric cancer:the impact of reconstructive route in the Roux en-Y procedure显示文摘 | YASUDA M TAKESUE F | 2001 | Hepatogastroenterology2001，48，41： | 1 |
| 15 | Security of differential-phase-shift quantum key distribution against individual attacks显示文摘 | WAKS E TAKESUE YAMAMOTO Y | 2006 | Phys Rev A2006，73，1： | 1 |
| 16 | Carbon and nutrient dynamics during coastal upwelling off cape blanco, oregon 显示文摘 | VAN G A TAKESUE R K GODDARD J | 2000 | Deep Sea Research Part II: Topical Studies in Oceanography2000，47，5： | 1 |
| 17 | 显示文摘 | Takesue Y Akimoto T Tabata S | 1999 | AlloysComp1999，，： | 1 |
| 18 | Risk factors associated with the development of thrombocytopenia 显示文摘 | Yoshiko Takahashi Yoshio Takesue Kazuhiko Nakajima | 2010 | Infect Chemother2010，，： | 1 |
| 19 | Hydriding-dehydriding behavior of magnesium composites obtained by mechanical grinding with graphite carbon 显示文摘 | Imamura H Tabata S Takesue Y Sakata Y Kamazaki S | 2000 | Inter J Hydrogen Energy2000，25，： | 1 |
| 20 | 查看详情显示文摘 | Zhang Q Takesue H Nam S W Langrock C Xie X Baek B Feje M M Yamamoto Y | | 0，，： | 1 |
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