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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | A Novel Strategy to Fabricate γ-Fe2O3-MWCNTs Hybrids with Selectively Ferromagnetic or Superparamagnetic Properties 显示文摘 | Fan X B Tan F Y Zhang G L | 2007 | Mater Sci & Eng A2007，45，： | 1 |
| 4 | Rutting prediction of asphah pave ment layer using C -φ model显示文摘 | Fwa T F Tan S A Zhu L Y | 2004 | Journal of Transportation En gineering ASCE2004，130，5： | 1 |
| 5 | High-strength reinforced concrete deep and short beams:shear design equations in North America and UK practice显示文摘 | Tan K H Dong F K Weng L W | 1998 | ACI Structural Journal1998，95，3： | 1 |
| 6 | 16S ribosomal DNA analysis and char-acterization of lactic acid bacteria associated with traditional Tibetan Qula cheese made from yak milk显示文摘 | TAN Z F PANG H L DUAN Y H | 2010 | Animal Science Journal2010，81，： | 1 |
| 7 | Comparative mapping of QTLs for agronomic traits of rice across environment by using a doubled-haploid population显示文摘 | Lu C F Shen L H Tan Z B | 1997 | Theor Appl Genet1997，94，1： | 1 |
| 8 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 9 | 查看详情显示文摘 | Leong W L Mathews N Tan B Vaidyanathan S Dotz F Mhaisalkar S | | 0，，： | 1 |
| 10 | Fuzzy self-tuning of PID controller 显示文摘 | S Z He S Tan and F L Xu | 1993 | Fuzzy Sets Systems1993，，2： | 1 |
| 11 | Auditory 'steadystate evoked potentials in newborns 显示文摘 | Ricards F W Tan L E Cohen L T | 1994 | British Journal ofAudiology1994，28，6： | 1 |
| 12 | Control of a key transition from prostrate to erect growth in rice domestication显示文摘 | Tan L Li X Liu F Sun X Li C Zhu Z Fu Y Cat H Wang X Xie D Sun C | 2008 | Nature Genetics2008，40，11： | 1 |
| 13 | 查看详情显示文摘 | Liu L Li F Tan L Ming L Yi Y | | 0，，： | 1 |
| 14 | The use of external fixation combined with vacuum sealing drainage to treat open com- minuted fractures of tibia in the Wenchuan earthquake显示文摘 | Liu L Tan G Luan F | 2012 | Int Orthop2012，36，7： | 1 |
| 15 | Different accumulation profiles of multiple components between pericarp and seed of Alpinia oxyphylla capsular fruit as determined by UFLC-MS/MS显示文摘 | CHEN F LI H L TAN Y F | 2014 | Molecules2014，19，： | 1 |
| 16 | Discretization: An enabling technique显示文摘 | LIU H HUSSAIN F TAN C L | 2002 | Data Mining and Knowledge Discovery2002，6，： | 1 |
| 17 | Effects of the ancillary ligands of polypyridyl ruthenium (II) : complexes on the DNA-binding and photocleavage behaviors 显示文摘 | TAN L F CHAO H ZHEN K C | 2007 | Polyhedron2007，26，18： | 1 |
| 18 | Singularities in motion and displacement functions of spatial link- ages 显示文摘 | LITVIN F L FANGHELLA P TAN J | 1986 | ASME Journal of Mechanism Transmission and Automation in Design-Transactions1986，108，4： | 1 |
| 19 | Atmospheric mercury deposition in Guizhou, China显示文摘 | Tan H He J L Liang L Lazoff S Sommer J Xiao Z F Lindqvist O | 2000 | The Science of the Total Environment2000，259，13： | 1 |
| 20 | A numerical study of solidification of n-hexadecane based on the enthalpy formulation 显示文摘 | Duan Q Tan F L Leong K C | 2002 | Journal of Materials Processing Technology2002，120，1： | 1 |
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