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| 1 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 2 | Chronic hepatitis C virus infection:Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients显示文摘AIM: To assess the prevalence of extrahepatic manifestations in Bulgarian patients with chronic hepatitis C virus (HCV) infection and identify the clinical and biological manifestations associated with cryoglobulinemia. METHODS: The medical records of 136 chronically infected HCV patients were reviewed to assess the prevalence of extrahepatic manifestations. Association between cryoglobulin-positivity and other manifestations were identified using χ2 and Fisher’s exact test. Risk factors for the presence of extrahepatic manifestations were assessed by logistic regression analysis. RESULTS: Seventy six percent (104/136) of the patients had at least one extrahepatic manifestation. Clinical manifestations included fatigue (59.6%), kidney impairment (25.0%), type 2 diabetes (22.8%), paresthesia (19.9%), arthralgia (18.4%), palpable purpura (17.6%), lymphadenopathy (16.2%), pulmonary fi brosis (15.4%), thyroid dysfunction (14.7%), Raynaud’s phenomenon (11.8%), B-cell lymphoma (8.8%), sicca syndrome (6.6%), and lichen planus (5.9%). The biological manifestations included cryoglobulinproduction (37.5%), thrombocytopenia (31.6%), and autoantibodies: anti-nuclear (18.4%), anti-smooth muscle (16.9%), anti-neutrophil cytoplasm (13.2%) and anti-cardiolipin (8.8%). All extrahepatic manifestations showed an association with cryoglobulin-positivity, with the exception of thyroid dysfunction, sicca syndrome, and lichen planus. Risks factors for the presence of extrahepatic manifestations (univariate analysis) were: age ≥ 60 years, female gender, virus transmission by blood transfusions, longstanding infection (≥ 20 years), and extensive liver fi brosis. The most signifi cant risks factors (multivariate analysis) were longstanding infection and extensive liver fi brosis. CONCLUSION: We observed a high prevalence of extrahepatic manifestations in patients with chronic HCV infection. Most of these manifestations were associated with impaired lymphoproliferation and cryoglobulin production. Longstanding infection and extensive liver fi brosis were signifi cant risk factors for the presence of extrahepatic manifestations in HCV patients. | Diana V Stefanova-Petrova Anelia H Tzvetanska Elisaveta J Naumova Anastasia P Mihailova Evgenii A Hadjiev Rumiana P Dikova Mircho I Vukov Konstantin G Tchernev | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 3 | In vitro generation of islets in long term cultures of pluripotent stem cells from adult mouse pancreas显示文摘 | Tchernev V Kao K J | 1997 | Horm Metab Res1997，29，6： | 1 |
| 4 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 5 | Identification of mutations in two major mRNA isofomls of the Chediak-Higashi syndrome gene in human and mouse显示文摘 | Barbosa M D Barrat F J Tchernev V T | 1997 | Hum Mol Genet1997，6，7： | 1 |
| 6 | Familial benign chronic pemphigus (Hailey-Hailey Disease) : use of topical immunomodulators as a modern treatment option 显示文摘 | Tchernev G Cardoso JC | 2011 | Rev Med Chil2011，139，5： | 1 |
| 7 | Object-oriented methodology for FMS modeling and simulation显示文摘 | Kelleret P Tchernev N Force C | 1997 | International Journal of Computer Integrated Manufacturing1997，10，6： | 1 |
| 8 | A dynamic longitudinal examination of social media use, needs, and gratifications among college students显示文摘 | WANG Z TCHERNEV M J SOLLOWAY T | 2012 | Computers in Human Behavior2012，28，5： | 1 |
| 9 | A combined financial and physical flows valuation for logistic process and tactical production planning: application in a company supply chain 显示文摘 | Mickael Comelli Pierre Fenies Nikolay Tchernev | 2008 | International Journal of Production Economies2008，112，： | 1 |
| 10 | A combinedfinancial and physical flows evaluation for logisticprocess and tactical production planning : application ina company supply chain 显示文摘 | GOMELLI M FENIES P TCHERNEV N | 2008 | International Journal ofProduction Economics2008，，112： | 1 |
| 11 | Regenerative zeolite heat pump 显示文摘 | Tchernev D I | 1989 | Studies in Surface Science and Catalysis1989，49，1： | 1 |
| 12 | Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis显示文摘 | Fecker LF Geilen CC Tchernev G | 2006 | J Invest Dermatol2006，126，6： | 1 |
| 13 | Primary onychomy- cosis with granulomatous Tinea faciei显示文摘 | Tchernev G Cardoso JC Ali MM et aI | 2010 | Braz J Infect Dis2010，14，5： | 1 |
| 14 | High-efficiency regenerative zeolite heat pump显示文摘 | Tchernev D I Emerson D T | 1988 | ASHRAE Trans1988，94，： | 1 |
| 15 | Clinical charac- teristics and management of iron overload in 631 patients with chronic transfusion dependency: results from a muhicentre, observational study 显示文摘 | Kemmoe S Lacomme P Tchernev N | 2013 | Blood transfusion = Trasfusione del sangue2013，121，1： | 1 |
| 16 | In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas显示文摘 | Tchernev V Kao KJ | 1997 | Horm Metab Res1997，29，： | 1 |
| 17 | Object-oriented methodology for FMS modelling and simulation显示文摘 | Patrick Kellert Nikolay Tchernev Christine Force | 1997 | International Journal Computer Integrated Manufacturing1997，10，6： | 1 |
| 18 | Antibodies against phospholipids in patients with normal pregnancy显示文摘 | Karagjozova Zh Tchernev T Baleva M | 2013 | Akush Ginekol2013，52，1： | 1 |
| 19 | Fluorescence imaging of electrical activity in cardiac cells using an all solid state system显示文摘 | ENTCHEVA E KOSTOV Y TCHERNEV E | 2004 | IEEE Trans Biomed Eng2004，51，2： | 1 |
| 20 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
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