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| 1 | Carbohydrate antigen 19-9 — tumor marker: Past, present, andfuture显示文摘Carbohydrate antigen 19-9 (CA 19-9) is a cell surface glycoprotein complex mostcommonly associated with pancreatic ductal adenocarcinoma (PDAC). Koprowskifirst described it in 1979 using a mouse monoclonal antibody in a colorectalcarcinoma cell line. Historically, it is one of the most commonly used tumormarkers for diagnosing, managing, and prognosticating PDAC. Additionally,elevated CA 19-9 levels are used as an indication for surgery in suspected benignpancreatic conditions. Another common application of CA 19-9 in the biliary tractincludes its use as an adjunct in diagnosing cholangiocarcinoma. However, itsclinical value is not limited to the hepatopancreatobiliary system. The reality isthat the advancing literature has broadened the clinical value of CA 19-9. Thepotential value of CA 19-9 in patients' workup extends its reach to gastrointestinalcancers – such as colorectal and oesophageal cancer – and further beyond thegastrointestinal tract - including urological, gynecological, pulmonary, andthyroid pathologies. Apart from its role in investigations, CA 19-9 presents apotential therapeutic target in PDAC and acute pancreatitis. In a bid toconsolidate its broad utility, we appraised and reviewed the biomarker’s currentutility and limitations in investigations and management, while discussing thepotential applications for CA 19-9 in the works for the future. | Tsinrong Lee Thomas Zheng Jie Teng Vishal G Shelat | 2020 | World Journal of Gastrointestinal Surgery2020，12，12： | 12 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 4 | Phase recovery and holographic image reconstruction using deep learning in neural networks显示文摘Phase recovery from intensity-only measurements forms the heart of coherent imaging techniques and holography.In this study,we demonstrate that a neural network can learn to perform phase recovery and holographic image reconstruction after appropriate training.This deep learning-based approach provides an entirely new framework to conduct holographic imaging by rapidly eliminating twin-image and self-interference-related spatial artifacts.This neural network-based method is fast to compute and reconstructs phase and amplitude images of the objects using only one hologram,requiring fewer measurements in addition to being computationally faster.We validated this method by reconstructing the phase and amplitude images of various samples,including blood and Pap smears and tissue sections.These results highlight that challenging problems in imaging science can be overcome through machine learning,providing new avenues to design powerful computational imaging systems. | Yair Rivenson Yibo Zhang Harun Günaydın Da Teng Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 5 | FRP-Strengthened RC beams( I ):Review of debonding strength models 显示文摘 | Smith S T Teng J G | 2002 | Engineering Structures2002，，24： | 2 |
| 6 | Acute appendicitis–advances and controversies显示文摘Being one of the most common causes of the acute abdomen,acute appendicitis(AA)forms the bread and butter of any general surgeon’s practice.With the recent advancements in AA’s management,much controversy in diagnostic algorithms,possible differential diagnoses,and weighing the management options has been generated,with no absolute consensus in the literature.Since Alvarado described his eponymous clinical scoring system in 1986 to stratify AA risk,there has been a burgeoning of additional scores for guiding downstream management and mortality assessment.Furthermore,advancing literature on the role of antibiotics,variations in appendicectomy,and its adjuncts have expanded the surgeon’s repertoire of management options.Owing to the varied presentation,diagnostic tools,and management of AA have also been proposed in special groups such as pregnant patients,the elderly,and the immunocompromised.This article seeks to raise the critical debates about what is currently known about the above aspects of AA and explore the latest controversies in the field.Considering the ever-evolving coronavirus disease 2019 situation worldwide,we also discuss the pandemic’s repercussions on patients and how surgeons’practices have evolved in the context of AA. | Thomas Zheng Jie Teng Xuan Rong Thong Kai Yuan Lau Sunder Balasubramaniam Vishal G Shelat | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 7 | Choledochoscopy:An update显示文摘Choledochoscopy,or cholangioscopy,is an endoscopic procedure for direct visualization within the biliary tract for diagnostic or therapeutic purposes.Since its conception in 1879,many variations and improvements are made to ensure relevance in diagnosing and managing a range of intrahepatic and extrahepatic biliary pathologies.This ranges from improved visual impression and optical guided biopsies of indeterminate biliary strictures and clinically indistinguishable pathologies to therapeutic uses in stone fragmentation and other ablative therapies.Furthermore,with the evolving understanding of biliary disorders,there are significant innovative ideas and techniques to fill this void,such as nuanced instances of biliary stenting and retrieving migrated ductal stents.With this in mind,we present a review of the current advancements in choledochoscopy with new supporting evidence that further delineates the role of choledochoscopy in various diagnostic and therapeutic interventions,complications,limitations and put forth areas for further study. | Tsinrong Lee Thomas Zheng Jie Teng Vishal G Shelat | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 2 |
| 8 | Broad-band excited quantum cutting in Eu^2+-Yb^3+ co-doped aluminosilicate glasses 显示文摘 | ZHOU J TENG Y LIN G | 2010 | J Electrochem Soc2010，157，8： | 1 |
| 9 | Hybrid FRP-concrete-steel tubular col- umns:concept and behavior 显示文摘 | Teng J G Yu T Wong Y L | 2007 | Construction and Building Mate- rials2007，21，4： | 1 |
| 10 | In vivo gene expression profile analysis of human breast cancer progression显示文摘 | Sgroni DC Teng S Robinson G | 1999 | Cancer Res1999，59，： | 1 |
| 11 | Stress-strain behavior of concrete in hybrid FRP-concrete-steel double-skin tu- bular columns 显示文摘 | YU T TENG J G WONG Y L | 2010 | Journal of Structural Engineering2010，136，4： | 1 |
| 12 | Biodiesel from palm oil via loading KF/Ca-A1 hydrotalcite catalyst显示文摘 | Gao L J Teng G Y Xiao G M | 2010 | Biomass and Bioenergy2010，34，： | 1 |
| 13 | Interracial stresses in soffit-plated reinforced concrete beams 显示文摘 | Yang J Teng J G Chen J F | 2004 | Structures & Buildings2004，157，1： | 1 |
| 14 | Finite Element Modeling of Confined Concrete-I:Drucker-Prager Type Plasticity Model显示文摘 | Yu T Teng J G Wong Y L | 2010 | Engineering Structures2010，32，3： | 1 |
| 15 | Silencing by microRNA-155 显示文摘 | Teng G Papavasiliou FN Shhh | 2009 | Philos T R Soc B2009，364，1517： | 1 |
| 16 | Multimerization and fusion expression of bovine lactoferricin derivative LfcinB15-W4,10 in Escherichia coli显示文摘 | TIAN Z G TENG D YANG Y L | 2007 | Appl Microbiol Blot2007，75，1： | 1 |
| 17 | Flexural behavior of hybrid FRP- concrete-steel double-skin tubular members 显示文摘 | Yu T Wong Y L Teng J G | 2006 | Journal of Com- posites for Construction ASCE2006，10，5： | 1 |
| 18 | Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics显示文摘 | GALATI G TENG S MORIDANI M Y | 2000 | Drug Metab Drug Interact2000，17，： | 1 |
| 19 | Large-span woven web structure made of fiber-reinforced polymer 显示文摘 | Feng Peng Ye Lie-ping Teng J G | 2007 | Journal of Composites for Construction2007，11，2： | 1 |
| 20 | Behavior of hybrid FRP-concrete-steel double-skin tubular columns subjec- ted to eccentric compression显示文摘 | YU T WONG Y L TENG J G | 2010 | Advances in Structural Engineering2010，13，5： | 1 |
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