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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Hybrid FRP-concrete-steel tubular col- umns:concept and behavior 显示文摘 | Teng J G Yu T Wong Y L | 2007 | Construction and Building Mate- rials2007，21，4： | 1 |
| 3 | Preparation of activated carbon from bituminous coal with phosphoric acid activation显示文摘 | Teng H Yeh T S Hsu L Y | 1999 | Carbon1999，36，： | 1 |
| 4 | Stress-strain behavior of concrete in hybrid FRP-concrete-steel double-skin tu- bular columns 显示文摘 | YU T TENG J G WONG Y L | 2010 | Journal of Structural Engineering2010，136，4： | 1 |
| 5 | Intelligent controlled- wind-turbine emulator and induction-generator system using RBFN显示文摘 | Lin F J Teng L T Shieh P H | 2006 | IEEE Proceedings of Electric Power Applications2006，153，4： | 1 |
| 6 | Finite Element Modeling of Confined Concrete-I:Drucker-Prager Type Plasticity Model显示文摘 | Yu T Teng J G Wong Y L | 2010 | Engineering Structures2010，32，3： | 1 |
| 7 | Flexural behavior of hybrid FRP- concrete-steel double-skin tubular members 显示文摘 | Yu T Wong Y L Teng J G | 2006 | Journal of Com- posites for Construction ASCE2006，10，5： | 1 |
| 8 | Effect of welding conditions on residual stresses due to butt welds显示文摘 | Teng T L Lin C C | 1998 | International of Pressure Vessels and Piping1998，75，12： | 1 |
| 9 | Behavior of hybrid FRP-concrete-steel double-skin tubular columns subjec- ted to eccentric compression显示文摘 | YU T WONG Y L TENG J G | 2010 | Advances in Structural Engineering2010，13，5： | 1 |
| 10 | Finite Element Modeling of Confined Concrete-II:Plastic-Damage Model显示文摘 | Yu T Teng J G Wong Y L | 2010 | Engineering Structures2010，32，3： | 1 |
| 11 | Analysis of residual stresses and distortion in T-joint filler welds显示文摘 | Teng T L Fung C P Chang P H | 2001 | Intemational Journal of Pressure Vessel and Piping2001，78，： | 1 |
| 12 | Stress-Strain Behavior of Concrete in Hybrid FRP-Concrete-Steel Double-Skin Tubular Columns显示文摘 | Yu T Teng J G Wong Y L | 2010 | Journal of Structural Engineering2010，136，4： | 1 |
| 13 | An Inventory Model for Increasing Demand under Two Levels of Trade Credit Linked to Order Quantity显示文摘 | Teng J T Yang G L Chern M S | 2013 | Applied Mathematical Modelling2013，，37： | 1 |
| 14 | Partial backlogging inventory lot-size models for deteriorating items with fluctuating demand under inflation 显示文摘 | Chern M S Yang H L Teng J T Papachristos S | 2008 | European Journal of Operational Research2008，191，1： | 1 |
| 15 | Intelligent adaptive backstep- ping control system for Magnetic Levitation Apparatus 显示文摘 | LIN F J TENG L T SHIEH P H | 2007 | IEEE Transactions on Magnetics2007，43，5： | 1 |
| 16 | Refinement of a DesignOriented Stress-Strain Model for FRP-Confined Concrete显示文摘 | Teng J G Jiang T Lam L | 2009 | Journal of Composites for Construction2009，13，4： | 1 |
| 17 | An Economic Order Quantity Model for Deteriorating Items with Partially Permissible Delay in Payments Linked to Order Quantity显示文摘 | Ouyang L Y Teng J T Goyal S K Yang C T | 2009 | European Journal of Operational Research2009，194，2： | 1 |
| 18 | Improvement of alum andPAC1 coagulation by plolyacrylamides for the treatment of pulp and papermill wastewater显示文摘 | AHM AD A L WONG S S TENG T T | 2007 | Chemical Engineering Joumal2007，5279，8： | 1 |
| 19 | Flexural behavior of hybrid FRP-concrete-steel double-skin tubular members 显示文摘 | Yu T Wong Y L Teng J G | 2006 | Journal of Composites for Construction2006，10，5： | 1 |
| 20 | Effeets of n-3 poly- unsaturated fatty acid therapy on plasma inflammatory markers and N-terminal pro-brain natriuretie peptide in elderly patients with chronie heart failure 显示文摘 | Zhao Y T Shao L Teng L L | 2009 | J Int Med Res2009，37，6： | 1 |
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