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| 1 | Implication of altered proteasome function in alcoholic liverinjury显示文摘The proteasome is a major protein-degrading enzyme, which catalyzes degradation of oxidized and aged proteins, signal transduction factors and cleaves peptides for antigen presentation. Proteasome exists in the equilibrium of 26S and 20S particles. Proteasome function is altered by ethanol metabolism, depending on oxidative stress levels: low oxidative stress induces proteasome activity, while high oxidative stress reduces it. The proposed mechanisms for modulation of proteasome activity are related to oxidative modification of proteasomal proteins with primary and secondary products derived from ethanol oxidation. Decreased proteolysis by the proteasome results in the accumulation of insoluble protein aggregates, which cannot be degraded by proteasome and which further inhibit proteasome function. Mallory bodies, a common signature of alcoholic liver diseases, are formed by liver cells, when proteasome is unable to remove cytokeratins. Proteasome inhibition by ethanol also promotes the accumulation of pro-apoptotic factors in mitochondria of ethanol-metabolizing liver cells that are normally degraded by proteasome. In addition, decreased proteasome function also induces accumulation of the negative regulators of cytokine signaling (I-kB and SOCS), thereby blocking cytokine signal transduction. Finally, ethanol-elicited blockade of interferon type 1 and 2 signaling and decreased proteasome function impairs generation of peptides for MHC class Ⅰ-restricted antigen presentation. | Natalia A Osna Terrence M Donohue Jr | 2007 | World Journal of Gastroenterology2007，13，37： | 10 |
| 2 | Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis显示文摘This review describes the principal pathways of macroautophagy (i.e. autophagy), microautophagy and chaperone-mediated autophagy as they are currently known to occur in mammalian cells. Because of its crucial role as an accessory digestive organ, the liver has a particularly robust autophagic activity that is sensitive to changes in plasma and dietary components. Ethanol consumption causes major changes in hepatic protein and lipid metabolism and both are regulated by autophagy, which is significantly affected by hepatic ethanol metabolism. Ethanol exposure enhances autophagosome formation in liver cells, but suppresses lysosome function. Excessive ethanol consumption synergizes with hepatitis C virus (HCV) to exacerbate liver injury, as alcohol-consuming HCV patients frequently have a longer course of infection and more severe manifestations of chronic hepatitis than abstinent HCV patients. Alcohol-elicited exacerbation of HCV infection pathogenesis is related to modulation by ethanol metabolism of HCV replication. Additionally, as part of this mechanism, autophagic proteins have been shown to regulate viral (HCV) replication and their intracel-lular accumulation. Because ethanol induces autophagosome expression, enhanced levels of autophagic proteins may enhance HCV infectivity in liver cells of alcoholics and heavy drinkers. | Natalia A Osna Paul G Thomes Terrence M Donohue | 2011 | World Journal of Gastroenterology2011，17，20： | 5 |
| 3 | Benzodiazepine and opioid use and theduration of intensive care unit delirium inan older population显示文摘 | Margaret A Terrence E Katy LB | 2009 | Crit Care Med2009，379，1： | 1 |
| 4 | The efficiency of enhanced biological phosphorus removal from real wastewater affected by different ratio of acetic to propionic acid显示文摘 | Yinguang Chen Andrew A R Terrence M | 2004 | Water Research2004，38，1： | 1 |
| 5 | The efficient of enhanced biological phosphorus removal from real wastewater affected by different rations of acetic to propionic acid显示文摘 | Chen Yingguang Randall Andrew A McCue Terrence | 2004 | Wat Res2004，38，： | 1 |
| 6 | Protection against H1, HS, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines显示文摘 | Ernst W A Kim H J Terrence M | 2006 | Vaccine2006，24，24： | 1 |
| 7 | Cholecystectomy in patients with mild cirrhosis显示文摘 | Terrence A Norman B | 1985 | Arch Surg1985，120，： | 1 |
| 8 | Aeroelastici- ty of nonconventional airplane configurations-past and future 显示文摘 | LIVNE E TERRENCE A WEISSHAAR | 2003 | Journal of aircraft2003，40，6： | 1 |
| 9 | Design and Realizationof a Digital Modulator for Fractional- Frequency Synthesis显示文摘 | Terrence P Kenny Thomas A D Riley Norman M Filiol Miles A Copeland | 1999 | IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY1999，48，2： | 1 |
| 10 | Ocular tropism of respiratory viruses 显示文摘 | Jessica A B Paul A R Terrence M T | 2013 | Microbiol Mol Biol Rev2013，77，3： | 1 |
| 11 | Non-parametric productivity analysis with undesirable outputs an application to the Canadian pulp and paper industry显示文摘 | Hailu A T Terrence S V | 2001 | American Journal of Agricultural Economics2001，83，3： | 1 |
| 12 | The efficiency of enhanced biological phosphorus removal from real wastewater affected by different ratio of acetic to propionic acid 显示文摘 | Chen Y G Andrew A R Terrence M C | 2004 | Water Research2004，38，1： | 1 |
| 13 | Human Resource Management's Role in Internal Branding:an Opportunity for Cross-functional Brand Message Synergy显示文摘 | TIMOTHY W A LINDA G TERRENCE R B | 2005 | Journal of Product & Brand Management2005，，143： | 1 |
| 14 | Requirements for sulfur amino acids and utilization of D-methionine by rainbow trout (Oncorhynchus mykiss) 显示文摘 | Kim K I Terrence B K Clyde H A | 1992 | Aquaculture1992，101，： | 1 |
| 15 | Combustion of alane and aluminum with water for hydrogen and thermal energy generation显示文摘 | CONNELL Terrence L Jr RISHA Grant A YETTER Richard A | 2011 | Proceedings of the Combustion Institute2011，33，： | 1 |
| 16 | Growth and ion accumulation in salicornia europaea under saline field conditions显示文摘 | Terrence E R Ungar I A | 1982 | Oecologia1982，54，2： | 1 |
| 17 | Private Acta and Public Objects-An Investigation of Citer Motivations显示文摘 | Terrence A Brooks | 1985 | Journal of the American Society for Information Science1985，36，4： | 1 |
| 18 | Industry differences in the production of audit services显示文摘 | Michael T Steins Dan A Simunic Terrence B O'Keefe | 1994 | Auditing: A Journal of Practice and Theory1994，13，： | 1 |
| 19 | The Operational Mesogamma-Scale Analysis and Forecast System of the U.S. Army Test and Evaluation Command. Part I: Overview of the Modeling System, the Forecast Products, and How the Products Are Used显示文摘 | Liu Yubao Warner Thomas T Bowers James F Carson Laurie P Chen Fei Clough Charles A Davis Christopher A Egeland Craig H Halvorson Scott F Huck Terrence W Lachapelle Leo Malone Robert E Rife Daran L Sheu Rong-Shyang Swerdlin Scott P Weingarte | 2008 | Journal of Applied Meteorology and Climatology2008，，4： | 1 |
| 20 | The efficiency of enhanced biological phosphorus removal from real wastewater affected by different ratios of acetic to propionic acid显示文摘 | Chen Y G Randall A A McCue Terrence | 2004 | Water Res2004，38，1： | 1 |
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