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| 1 | Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms显示文摘AIM:To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection(ESD)treatment for colorectal neoplasms.METHODS:We retrospectively reviewed the medical records of 317 consecutive patients with 325 lesions who underwent ESD for superficial colorectal neoplasms at our hospital from January 2009 to June2013.Delayed post-ESD bleeding was defined as bleeding that resulted in overt hematochezia 6 h to 30d after ESD and the observation of bleeding spots as confirmed by repeat colonoscopy or a required blood transfusion.We analyzed the relationship between risk factors for delayed bleeding following ESD and the following factors using univariate and multivariate analyses:age,gender,presence of comorbidities,use of antithrombotic drugs,use of intravenous heparin,resected specimen size,lesion size,lesion location,lesion morphology,lesion histology,the device used,procedure time,and the presence of significant bleeding during ESD.RESULTS:Delayed post-ESD bleeding was found in14 lesions from 14 patients(4.3%of all specimens,4.4%patients).Patients with episodes of delayed postESD bleeding had a mean hemoglobin decrease of2.35 g/dL.All episodes were treated successfully using endoscopic hemostatic clips.Emergency surgery was not required in any of the cases.Blood transfusion was needed in 1 patient(0.3%).Univariate analysis revealed that lesions located in the cecum(P=0.012)and the presence of significant bleeding during ESD(P=0.024)were significantly associated with delayed post-ESD bleeding.The risk of delayed bleeding was higher for larger lesion sizes,but this trend was not statistically significant.Multivariate analysis revealed that lesions located in the cecum(OR=7.26,95%CI:1.99-26.55,P=0.003)and the presence of significant bleeding during ESD(OR=16.41,95%CI:2.60-103.68,P=0.003)were independent risk factors for delayed post-ESD bleeding.CONCLUSION:Location in the cecum and significant bleeding during ESD predispose patients to delayed post-procedural bleeding.Therefore,careful and additional management is recommended for these patients. | Sho Suzuki Akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma Junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | New roles of osteoblasts involved in osteoclast differentiation显示文摘Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control o bone-forming osteoblasts. So far,macrophage colonystimulating factor(M-CSF),receptor activator o nuclear factor-κB ligand(RANKL),and osteoprotegerin(OPG) produced by osteoblasts play major roles in the regulation of osteoclast differentiation. Recent studies have shown that osteoblasts regulate osteoclastogenesis through several mechanisms independent o M-CSF,RANKL,and OPG production. Identification o osteoclast-committed precursors in vivo demonstrated that osteoblasts are involved in the distribution o osteoclast precursors in bone. Interleukin 34(IL-34)a novel ligand for c-Fms,plays a pivotal role in maintaining the splenic reservoir of osteoclast-committed precursors in M-CSF deficient mice. IL-34 is also able to act as a substitute for osteoblast-producing M-CSF in osteoclastogenesis. Wnt5 a,produced by osteoblasts,enhances osteoclast differentiation by upregulating RANK expression through activation of the noncanonical Wnt pathway. Semaphorin 3A produced by osteoblasts inhibits RANKL-induced osteoclast differentiation through the suppression of immunoreceptortyrosine-based activation motif signals. Thus,recent findings show that osteoclast differentiation is tightly regulated by osteoblasts through several different mechanisms. These newly identified molecules are expected to be promising targets of therapeutic agents in bone-related diseases. | Teruhito Yamashita Naoyuki Takahashi Nobuyuki Udagawa | 2012 | World Journal of Orthopedics2012，3，11： | 11 |
| 3 | Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment显示文摘瞄准:回顾地为 HCC 后面的 transcatheter 与肝细胞癌(HCC ) 评估病人的预后与或没有治疗的历史动脉的 embolization (TAE ) 。方法:有在我们的医院里从 1992 ~ 2004 与 TAE 对待的 HCC 的 121 个病人在这研究被注册。84 个病人为 HCC 有治疗的历史,当时 37。在入口,有额外肝的转移的病人,门静脉肿瘤血栓,或孩子呸班的时候, C 被排除。当 HCC 的复发被提高的肿瘤标记,或 ultrasonography 或动态计算断层摄影术调查结果诊断时, TAE 被重复。结果:肿瘤尺寸更大,没有过去的治疗(P<0.01 ) ,肿瘤的数字是在病人的少数。然而,在节点转移(TNM ) 舞台或幸存在 2 个组之间评估的肿瘤没有差别。一个双性人 alpha-fetoprotein (法新社)(>100 ng/mL ) 的小叶片的肿瘤和高水平是与在有 HCC 的历史的病人的差的预后有关的因素。结论:预后追随者 TAE 在有或没有过去的治疗的 HCC 病人之间是类似的。在到一堂重复 TAE 功课的入口能改进预后以前, HCC 或周期性的 HCC 和获得的好本地人的早诊断对 HCC 控制。 | Atsushi Hiraoka Teru Kumagi Masashi Hirooka Takahide Uehara Kiyotaka Kurose Hidehito luchi Yoichi Hiasa Bunzo Matsuura Kojiro Michitaka Seishi Kumano Hiroaki Tanaka Yoshimasa Yamashita Norio Horiike Teruhito Mochizuki Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 4 | The Class IV Semaphorin CD100 Plays Nonredundant Roles in the Immune System显示文摘 | Wei Shi Atsushi Kumanogoh Chie Watanabe Junji Uchida Xiaosong Wang Teruhito Yasui Kazunori Yukawa Masahito Ikawa Masaru Okabe Jane R Parnes Kanji Yoshida Hitoshi Kikutani | 2000 | Immunity2000，，5： | 2 |
| 5 | Treatment strategy for rectal carcinoids: A clinicopathological analysis of 229 cases at a single cancer institution显示文摘 | Akiyoshi Kasuga Akiko Chino Naoyuki Uragami Teruhito Kishihara Masahiro Igarashi Rikiya Fujita Noriko Yamamoto Masashi Ueno Masatoshi Oya Tetsuichiro Muto | 2012 | Journal of Gastroenterology and Hepatology2012，，12： | 2 |
| 6 | History of cardiac computed tomography: single to 320-detector row multislice computed tomography显示文摘 | Gregory S. Hurlock Hiroshi Higashino Teruhito Mochizuki | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 2 |
| 7 | An Inhibitory Role for Sema4A in Antigen-Specific Allergic Asthma显示文摘 | Tetsuo Morihana Sho Goya Masayuki Mizui Teruhito Yasui Durubaka V. R. Prasad Atsushi Kumanogoh Manabu Tamura Takashi Shikina Yohei Maeda Yoriko Iwamoto Hidenori Inohara Hitoshi Kikutani | 2013 | Journal of Clinical Immunology2013，，： | 1 |
| 8 | Intravenous three-dimensional CT portography using multi-detector row CT in patients with hepatic cirrhosis:evaluation of scan timing and image quality显示文摘 | Yamamoto Takaharu Tsuda Teruhito Mochizuki | 2002 | Radiation Medicine2002，20，： | 1 |
| 9 | Classification of Barrett’s epithelium by magnifying endoscopy显示文摘 | Takao Endo Teruhito Awakawa Hiroaki Takahashi Yoshiaki Arimura Fumio Itoh Kentaro Yamashita Sigeru Sasaki Hiroyuki Yamamoto Xiufen Tang Kohzoh Imai | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 10 | Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammography显示文摘 | Miho I. Yoshikawa Shozo Ohsumi Shigenori Sugata Masaaki Kataoka Shigemitsu Takashima Keiichi Kikuchi Teruhito Mochizuki | 2007 | Radiation Medicine2007，，5： | 1 |
| 11 | Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer显示文摘 | Miho I. Yoshikawa Shozo Ohsumi Shigenori Sugata Masaaki Kataoka Shigemitsu Takashima Teruhito Mochizuki Hirohiko Ikura Yutaka Imai | 2008 | Radiation Medicine2008，，： | 1 |
| 12 | Classification of Barrett’s epithelium by magnifying endoscopy显示文摘 | Takao Endo Teruhito Awakawa Hiroaki Takahashi Yoshiaki Arimura Fumio Itoh Kentaro Yamashita Sigeru Sasaki Hiroyuki Yamamoto Xiufen Tang Kohzoh Imai | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 13 | Wavefront analysis in eyes with nuclear or cortical cataract显示文摘 | Teruhito K Takashi F Naoyuki M | 2002 | American Journal of Ophthalmology2002，134，1： | 1 |
| 14 | Cardiac magnetic resonance imaging for assessment of steroid therapy in a patient with cardiac sarcoidosis and a magnetic resonance-conditional pacemaker显示文摘 | Tamami Kono Akiyoshi Ogimoto Makoto Saito Kaori Fujimoto Akira Fujii Teruyoshi Uetani Takayuki Nagai Kazuhisa Nishimura Katsuji Inoue Jun Suzuki Takafumi Okura Tomoyuki Kido Masao Miyagawa Teruhito Mochizuki Jitsuo Higaki | 2014 | International Journal of Cardiology2014，，3： | 1 |
| 15 | Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus显示文摘 | Naoyuki M Takashi F Teruhito K | 2002 | Ophthalmology2002，109，11： | 1 |
| 16 | History of cardiac computed tomography: single to 320-detector row multislice computed tomography显示文摘 | Gregory S. Hurlock Hiroshi Higashino Teruhito Mochizuki | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 1 |
| 17 | Diagnosis of laterally spreading tumors ( LST ) in the rectum and selection of treatment: Characteristics of each of the subclassifications of LST in the rectum显示文摘 | Yusuke Horiuchi Akiko Chino Yasumasa Matsuo Teruhito Kishihara Naoyuki Uragami Yoshiya Fujimoto Masashi Ueno Yoshiro Tamegai Etsuo Hoshino Masahiro Igarashi | 2013 | Digestive Endoscopy2013，，6： | 1 |
| 18 | Peri-infarct dysfunction in post-myocardial infarction: assessment of 3-T tagged and late enhancement MRI显示文摘 | Yuma Inoue Xiaomei Yang Michinobu Nagao Hiroshi Higashino Kohei Hosokawa Teruhito Kido Akira Kurata Hideki Okayama Jitsuo Higaki Teruhito Mochizuki Kenya Murase | 2010 | European Radiology2010，，： | 1 |
| 19 | High-performance scaffolds on titanium surfaces:osteoblast differentiation and minerlization promoted by a globular fibrinogen layer through cell-autonomous BMP signaling显示文摘 | Noriko H Teruhito Y Shunsuke U | 2015 | Material Science and Engineering2015，，46： | 1 |
| 20 | Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report显示文摘 | Teruhito Kido Akira Kurata Hiroshi Higashino Yoshifumi Sugawara Hideki Okayama Jitsuo Higaki Hirofumi Anno Kazuhiro Katada Shinichiro Mori Shuji Tanada Masahiro Endo Teruhito Mochizuki | 2007 | Radiation Medicine2007，，1： | 1 |
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