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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | FI'-IR measurements of petroleum fluid inclusions : Methane, n-alkanes, and carbon dioxide quantitative analysis 显示文摘 | Pironon J Thiery R Aytougougdal M Teinturier S Beaudoin G Walgenwitz F | 2001 | Geofluids2001，，1： | 1 |
| 3 | Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum显示文摘 | Tahar R Boudin C Thiery I | 2002 | EMBO J2002，21，24： | 1 |
| 4 | Pseudorabies virus latency:aquantitative app roach by polymerase chain reaction显示文摘 | Thiery R Boutin P Arnauld C | 1994 | Acta VeterinariaHungarica1994，42，2： | 1 |
| 5 | Masti-tis impact on technological properties of milk and quality of milk products-a review显示文摘 | LE MARECHAL C THIERY R VAUTOR E | | 0，，3： | 1 |
| 6 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 7 | Individual character- ization of petroleum fluid inclusions (composition and P-T trapping conditions) by microthermometry and confocaI laser scanning microscopy: Inferences from applied thermodynamics of oils显示文摘 | Thiery R Pironon J Walgenwitz F | 2002 | Marine and Petroleum Geology2002，19，7： | 1 |
| 8 | Thermodynamic modeling of petro- leum inclusions: The prediction of the saturation pressure of crude oils显示文摘 | Ping H Thiery R Chen H | 2011 | Geofluids2011，11，3： | 1 |
| 9 | V-x propertiesof CH4-CO2 and CO2-N2 fluid inclusions:Modelling for T<31℃and P<400 bars显示文摘 | Thiery R Van Dan Kerkhof A M Dubessy J | 1994 | European Journal of Mineralogy1994，6，： | 1 |
| 10 | Sea bream Sparus aurata an asymptomatic contagious fish host for nodavirus显示文摘 | Castric J Thiery R Jeffroy J | 2001 | Disease of Aquatic Organisms2001，47，： | 1 |
| 11 | 2001Carbonic inclusions显示文摘 | Van den Kerkhof A M and Thiery R | 2001 | Lithos2001，55，： | 1 |
| 12 | a fluorescence-based quantitative PCR method inverstigation of pseudorabiea virus latency 显示文摘 | Thiery R Pannetier C Rziha H J | 1996 | J Virol Methods1996，61，： | 1 |
| 13 | Sea bream Sparus aurata, an asymptomatic contagious fish host for nodavirus 显示文摘 | Castri J Thiery R Jeffroy J | 2001 | Dis Aquatic Organ2001，47，1： | 1 |
| 14 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 15 | Epithelial-mesenchymal transitions in development and disease 显示文摘 | THIERY J P ACLOQUE H HUANG R Y | 2009 | Cell2009，139，5： | 1 |
| 16 | Pseudorabies virus latencyz a quantitative approach by polymerase chain reaction显示文摘 | Thiery R Boutin P Arnauld C | 1994 | Acta Veterinaria Hungarica1994，42，2： | 1 |
| 17 | Natural outbreak of viral encephalopathy and retinopathy in juvenile sea bass Dicentrarchus labrax: study by nested reverse transcriptase-polymerase chain reaction 显示文摘 | Thiery R Raymond J C Castric J | 1999 | Virus Research1999，63，： | 1 |
| 18 | Epithelial- mesenchymal transitions in development and disease显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 19 | Epithelial-Mesenchymal transitions in development and disease显示文摘 | Thiery J P Acloque H Huang R Y | 2009 | Cell2009，139，5： | 1 |
| 20 | Mastitis impact on technological properties of milk and quality of milk products-a review 显示文摘 | Le Marechal C Thiery R Vautor E | 2011 | Dairy Sci Technol2011，91，： | 1 |
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