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| 1 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Formal aspects of a generic model of trust for electronic commerce显示文摘 | Tan Y H Thoen W | | 0，，： | 1 |
| 3 | Evidence for size-dependent electron deiocalization in the ionization potentials of lithium monocarbide clusters 显示文摘 | LIVENS P THOEN P BOUCHAERT S | 1999 | Chemical Physics Letters1999，302，56： | 1 |
| 4 | Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease 显示文摘 | Bramlage P Swift S L Thoenes M | 2016 | Eur J Heart Fail2016，18，1： | 1 |
| 5 | Novel approaches in anti-angiogenic treat- ment targeting endothelial F-aetin: a new anti-angiogenic strategy?显示文摘 | Thoenes L GO nther M | 2008 | Curr Opin Mol Ther2008，10，6： | 1 |
| 6 | The effects of extended-release niacin on carotid intimal media thick- ness, endothelial function and inflammatory, markers in patients with the metabolic syndrome 显示文摘 | THOENES M OQUCHI A VACCARI C S | 2007 | International Journal of Clinical Practice2007，61，11： | 1 |
| 7 | Human chromophobe cell renal carcinoma显示文摘 | Thoenes W Storkel S Rumpelt HJ | 1985 | Virchows Arch B Cell Pathol Incl Mol Pathol1985，48，3： | 1 |
| 8 | Leflunomide(HWA 486)inhibits experimental autoimmune tubulointerstitial nephritis in rats显示文摘 | Thoenes GH Sitter T Langer KH | 1989 | Int J Immunopharmacol1989，11，8： | 1 |
| 9 | Histopathology and classifi- cation of renal cell tumors the basic cytological and histopathological elements and their use for diagnosistics 显示文摘 | Thoenes W Strokel S Rumpeh HJ | 1986 | Pathol Res Pratt1986，181，： | 1 |
| 10 | Formal aspects of a generic model of trust for electronic commeree显示文摘 | Tan Y Thoen W | 2002 | Decision Support Systems2002，33，3： | 1 |
| 11 | Cystinosis显示文摘 | Gahl WA Thoene JG Schneider JA | 2002 | N Engl J Med2002，347，： | 1 |
| 12 | Changes in the Th1 or Th2 cytokine dominance in the synovium of rheumatoid arthritis (RA):A kinetic study of the Th subsets in one unusual RA patient显示文摘 | Aarvak T Chabaud M Thoen J | 2000 | Rheumatology2000，39，5： | 1 |
| 13 | Laser Ultrasonic study of Lamb waves: Determination of the thickness and velocities of a thin plate显示文摘 | Weimin Gao Christ Glorieux Jan Thoen | 2003 | International Journal of Engineering'' Science2003，41，2： | 1 |
| 14 | A role for autophagy during hepatic stellate cell activation显示文摘 | Thoen LF Guimar(a)es EL Dollé L | 2011 | J Hepatol2011，55，： | 1 |
| 15 | Leflunomide inhibits experimental autoimmune tubulointerstitial nephritis in rats 显示文摘 | Thoenes GH | 1998 | Int J Immunopharmacol1998，11，2： | 1 |
| 16 | RhabdomyOlysis: when exercising becomes a risk显示文摘 | Thoenes M | 2010 | Jour- nal of Pediatric Health Care2010，24，3： | 1 |
| 17 | A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb - group gene EZH2 in lymphomagenesis 显示文摘 | Berg T Thoene S Yap D | 2014 | Blood2014，123，25： | 1 |
| 18 | Human chromophobe cell renal carcinoma 显示文摘 | Thoenes W Storkel S Rumpelt H J | 1985 | Virchows Aruh ( Cell Pathol )1985，48，： | 1 |
| 19 | Arole for autophagy during hepatic stellate cell activation显示文摘 | Thoen LF Guimar(a)es EL Dollé L | | 0，，： | 1 |
| 20 | Prevention of D-galactosamine-induced hepatocellular autophagocytosis by cycloheximide显示文摘 | H. J. Rumpelt M. Albring W. Thoenes | 1974 | Virchows Archiv B Cell Pathology1974，，1： | 1 |
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