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| 1 | Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients显示文摘Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC afterNAC.Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with NSCLC.We evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine learning.Methods:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with NSCLC.The specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%accuracy.By contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,respectively.The combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic classifier.In multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic factors.Using Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non-responders(P<0.001).Conclusions:Our findings indicate that the metabolic constitutions of both tumor cells and the stroma are valuable additions to the classical histomorphology-based assessment of tumor response. | Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch | 2022 | Cancer Communications2022，42，6： | 3 |
| 2 | Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters显示文摘联合精力的因素(ECF ) transporters 是调停的多子单元蛋白质建筑群在大约 50% 初核质的转变金属离子和维生素的举起,包括细菌和 archaea。生物、结构的研究为维生素,而是 ECF 系统从未知的环境遗体由搬运金属离子的分子的机制集中于 ECF transporters。这里,我们报导 NikM 的第一水晶结构, TtNikM2,从 Thermoanaerobacter tengcongensis 的 ECF 类型镍 transporter 的底层绑定部件(S 部件) 。与有六个 transmembrane 片断(TS ) 的维生素特定的 S 蛋白质的结构相对照, TtNikM2 在它的 N 终端区域拥有另外的 TS,导致细胞外的 N 终点。高度保存的 N 终端环插入到 TtNikM2 的中心并且堵塞相应于维生素特定的 S 部件的底层绑定地点的一个区域。镍经由它的协作绑在 NikM 到四个氮原子,它从 Met1, His2 和 His67 残余被导出。这些氮原子形成近似平方平面的几何学,类似于在 2+ 有约束力的氨基终端的 Cu 和 Ni 2+-binding (ATCUN ) 的金属离子绑定地点的主题。在贡献镍协作的 NikM 的残余的代替损害了 Ni 运输活动。而且,系统的量化学药品调查显示这几何学启用 NikM 到有选择地也认出公司 2+ 。确实,包含一个界限公司 2+ 离子的 TtNikM2 的结构没几乎与包含五分钱离子的结构相比有 conformational 变化。一起,我们的数据揭示位于 EcfS 蛋白质的金属选择下面的 evolutionarily 保存的机制,并且提供卓见进 ion-translocation 过程由 ECF transporters 调停了。 | You Yu Mingze Zhou Franziska Kirsch Congqiao Xu Li Zhang Yu Wang Zheng Jiang Na Wang Jun Li Thomas Eitinger Maojun Yang | 2014 | Cell Research2014，24，3： | 3 |
| 3 | CaWRKY40, a WRKY protein of pepper, plays an important role in the regulation of tolerance to heat stress and resistance to Ralstonia solanacearum infection显示文摘 | FENG‐FENG DANG YU‐NA WANG LU YU THOMAS EULGEM YAN LAI ZHI‐QIN LIU XU WANG AI‐LIAN QIU TING‐XIU ZHANG JING LIN YAN‐SHENG CHEN DE‐YI GUAN HAN‐YANG CAI SHAO‐LIANG MOU SHUI‐LIN HE | 2012 | Plant, Cell & Environment2012，，： | 2 |
| 4 | An instrument to measure healing in pressure ulcers:Development and validation of the pressure ulcer scale for healing (PUSH)显示文摘 | Stotts NA Rodeheaver GT Thomas DR | 2001 | Gerontol A Biol Sei Med Sci2001，56，： | 1 |
| 5 | The Performance of Chinese Private Firms in Coping with a Global Financial Crisis: Who Is Best Positioned?显示文摘把组织上的灵活性用作一个研究透镜,我们调查怎么私人公司,特别制造工程师协会,在中国应付 2008 金融危机。从由差别不在乎分析的私人公司(N=3,459 ) 的一件大样品的严峻的数据,我们发现没有,有工业多样化,地理扩大和政治连接的公司比那些在危机期间更好表现。这些结果被自己挑选问题少些影响(当突然的危机提供一个自然实验) 并且对 endogeneity 和几 nberg 举起, 2008 ) 。察觉的领导有效性,为研究人员的 job-satiportant 含意,企业主人,政策制造者和未来研究。 | Na Shen Kevin Au Thomas Birtch | 2016 | Frontiers of Business Research in China2016，10，4： | 1 |
| 6 | The archaeal flagellum : a dif- ferent kind of prokaryotic motility structure 显示文摘 | Thomas NA Bardy SL Jarrell KF | 2001 | FEMS Microbiol Rev2001，25，2： | 1 |
| 7 | Identification and characterization of NleA,a non-LEE encoded type Ⅲ translocated virulence factor of enterohaemorrhagic Escherichia coli O157∶H7显示文摘 | Gruenheid S Sekirov I Thomas NA | 2004 | Mol Microbiol2004，51，： | 1 |
| 8 | The pattern and course of cognitive impairment in late-life depression 显示文摘 | Kohler S Thomas A J Barnett NA | 2010 | Psychol Med2010，40，： | 1 |
| 9 | Terminal osteoblast differentiation,mediated by runx2 and p27kipl, is disrupted in osteosareoma显示文摘 | Thomas DM Johnson SA Sims NA | 2004 | J Cell Biol2004，167，5： | 1 |
| 10 | Lower pretreatment cerebral blood volume affects hemorrhagic risks after intra-arterial revascularization in acute stroke显示文摘 | Bhatt A Vora NA Thomas AJ | 2008 | Neurosurgery2008，63，： | 1 |
| 11 | The archaeal flagellum: a different kind of prokaryotic motility structure 显示文摘 | Thomas NA Bardy SL Jarrell KF | 2001 | FEMS Microbiol Rev2001，25，2： | 1 |
| 12 | Terminal differentiation,mediated by runx2 and p27KIP1,is disrupted in osteosarcoma显示文摘 | Thomas DM Johnson SA Sims NA | 2004 | J Cell Biochem2004，167，： | 1 |
| 13 | Accuracy of needle placement into the intra-articular space of the knee显示文摘 | Jackson DW Evans NA Thomas BM | | 0，，09： | 1 |
| 14 | Factors predicting hemorrhag-ic complications after multimodal reperfusion therapy for acute isch- emic stroke 显示文摘 | Vora NA Gupta R Thomas A J | 2011 | Am J Neuroadiol2011，28，7： | 1 |
| 15 | Lower pre- treatment cerebral blood volume increases hemorrhagic risks after intra-arterial revascularization in acute stroke显示文摘 | Bhatt A Vora NA Thomas A J | 2008 | Neurosurgery2008，63，： | 1 |
| 16 | Estimating human energy expenditure:a review of techniques with particular reference to doubly labeled water 显示文摘 | Philip NA Thomas R Klass RW | 2003 | Sports Med2003，33，9： | 1 |
| 17 | Dietary protein restriction during F0 pregnancy in rats induces transgenerational chan- ges in the hepatic transcriptome in female offspring显示文摘 | Hoile SP Lillycrop KA Thomas NA Hanson MA Burdge GC | 2011 | PLoS One2011，6，21： | 1 |
| 18 | Identification and characterization of N1eA,a non-LEE-encoded type Ⅲ translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7显示文摘 | Gruenheid S Sekirov I Thomas NA | 2004 | Mol Microbiol2004，51，5： | 1 |
| 19 | Multiple cardiovascular involvement in a case of relapsing polychondritis显示文摘 | Sasirekha D Meena kshi NA Thomas JM | | 0，，： | 1 |
| 20 | Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas显示文摘 | Patrikis MI Bryan EJ Thomas NA | 2003 | Mol Carcinog2003，37，2： | 1 |
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