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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 3 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 4 | 活体牙周膜有限元仿真的可行性研究显示文摘目的通过现代有限元方法研究牙周膜上的静平衡应力状态。方法提出了两种用于分析牙周膜应力状态的有限元方法,把牙周膜看做是整个下颌模型的一部分,通过有限元方法来处理仿真的牙齿并加载,来研究牙周膜对牙周组织的应力应变分布的作用,计算得到的静平衡应力和牙齿根吸收状态进行比较。结果牙周膜的最大应力发生在接近最高点位置,在中跟位置附近存在局部最大应力,而牙周膜顶点区域的应力要大于牙周膜中根附近的局部最大应力。齿槽顶部的舌侧牙周膜部位可以发现静平衡应力。静平衡应力是和位置有关的,有静平衡应力的部位就会发生牙根吸收。结论人类切牙和单根前臼齿一样,植入物会导致其牙周膜顶点附近静平衡应力的增长,这一点同之前的发现相一致。人类切牙根吸收经常作用于牙周膜的顶点部位。 | Ansgar Hohmann Cornelia Kober Thomas Radtke Philippe Young Martin Geiger Andrew Boryor Christian Sander Franz Gunter Sander | 2008 | 医用生物力学2008，23，1： | 3 |
| 5 | BILIARY COMPLICATIONS IN 96 CONSECUTIVE RIGHT LOBE LIVING DONOR TRANSPLANT RECIPIENTS显示文摘 | Gabriel E. Gondolesi Giovanni Varotti Sander S. Florman Luis Mu?oz Thomas M. Fishbein Sukru H. Emre Myron E. Schwartz Charles Miller | 2004 | Transplantation2004，，12： | 3 |
| 6 | Improved Outcome of Resection of Hilar Cholangiocarcinoma (Klatskin Tumor)显示文摘 | Sander Dinant Michael F. Gerhards E. A. J. Rauws Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2006 | Annals of Surgical Oncology2006，，： | 2 |
| 7 | Appendectomy and Clostridium difficile colitis:Relationships revealed by clinical observations and immunology显示文摘Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon.These advances have been made despite long standing clinical observations that the appendectomy is a safe and effective procedure.However,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(C.difficile)-associated colitis,and probably other diseases associated with an altered microbiome.At the same time,appendectomy does not apparently put patients at risk for an initial onset of C.difficile-associated colitis.These clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of C.difficile-associated colitis.Further,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics. | Nathan L Sanders R Randal Bollinger Ryan Lee Steven Thomas William Parker | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 8 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 9 | Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-dirved hyperpolarizing factors, and prostaglandins 显示文摘 | Thomas D Giles Gary E Sander Bobby D Nossaman | 2012 | J Clin Hypertens2012，14，4： | 1 |
| 10 | Improved Outcome of Resection of Hilar Cholangiocarcinoma (Klatskin Tumor)显示文摘 | Sander Dinant MD Michael F. Gerhards MD E. A. J. Rauws MD Olivier R. C. Busch MD Dirk J. Gouma MD Thomas M. Gulik MD | 2006 | Annals of Surgical Oncology2006，，6： | 1 |
| 11 | Intolerance of osteosynthesis material : evidence of dichromate contact allergy with concomitant oligoclonal T-cell infiltrate and Thl-type eytokine expression in the peri-implantar tissue 显示文摘 | Thomas P Summer B Sander CA | 2000 | Allergy2000，55，： | 1 |
| 12 | Improved Outcome of Resection of Hilar Cholangiocarcinoma (Klatskin Tumor)显示文摘 | Sander Dinant MD Michael F. Gerhards MD E. A. J. Rauws MD Olivier R. C. Busch MD Dirk J. Gouma MD Thomas M. Gulik MD | 2006 | Annals of Surgical Oncology2006，，6： | 1 |
| 13 | Treatment of recurrent eosinophilic granuloma with systemic therapy显示文摘 | Alice S Thomas J Sander D | 2003 | Ophthal Plast Reconstr Surg2003，19，2： | 1 |
| 14 | Sympathetic neural mechanisms of cyclosporine-induced hypertension显示文摘 | Sander M Lyson T Thomas GD | 1996 | Am J Hypertens1996，9，11： | 1 |
| 15 | Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: A systematic review and meta-analysis显示文摘 | Thomas W. Lee Michael R. Kolber Richard N. Fedorak Sander Veldhuyzen van Zanten | 2011 | Journal of Crohn’s and Colitis2011，，3： | 1 |
| 16 | Impact oF Material Management on Productivity--A Case Study显示文摘 | Thomas H R Sanvido E Sanders S R | 1989 | Journal of Construction Engineering and Management1989，115，3： | 1 |
| 17 | Atrial Tachycardia After Circumferential Pulmonary Vein Ablation of Atrial Fibrillation显示文摘 | Sanders Chae Hakan Oral Eric Good Sujoya Dey Alan Wimmer Thomas Crawford Darryl Wells Jean-Francois Sarrazin Nagib Chalfoun Michael Kuhne Jackie Fortino Elizabeth Huether Tammy Lemerand Frank Pelosi Frank Bogun Fred Morady Aman Chugh | 2007 | Journal of the American College of Cardiology2007，，18： | 1 |
| 18 | Treatment of recurrent eosino2 philic granuloma wit h systemic t herapy显示文摘 | Thomas J Sander D | 2003 | Ophthal Plast Reconst r S urg2003，19，14： | 1 |
| 19 | Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma显示文摘 | Thomas DG Giordano TJ Sanders D | 2002 | Clin Cancer Res2002，8，3： | 1 |
| 20 | Solution-based synthesis of submierometer ZrB2 and ZrBe-TaBe 显示文摘 | Xie Yanli Thomas H Sanders Jr | 2008 | J Am Ceram Soc2008，91，5： | 1 |
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