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| 1 | Terpenoids as potential chemopreventive and therapeutic agents in liver cancer显示文摘Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called 'isoprenoids') are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed. | Roslin J Thoppil Anupam Bishayee | 2011 | World Journal of Hepatology2011，3，9： | 7 |
| 2 | Persian Gulf response to a wintertime shamal wind event显示文摘 | Prasad G. Thoppil Patrick J. Hogan | 2010 | Deep-Sea Research Part I2010，，8： | 1 |
| 3 | Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells显示文摘 | Roslin J. Thoppil Eli Harlev Animesh Mandal Eviatar Nevo Anupam Bishayee | 2013 | Pharmaceutical Biology2013，，5： | 1 |
| 4 | Warming ofthe Eurasian landmass is making the Arabian sea moreproductive显示文摘 | Goes J I Thoppil P G do R Gomes H | 2005 | Science2005，308，5721： | 1 |
| 5 | Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway显示文摘 | Deepak Bhatia Roslin J. Thoppil Animesh Mandal Karishma A. Samtani Altaf S. Darvesh Anupam Bishayee Ari M. Mackler | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 6 | Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis显示文摘 | Bishayee A Thoppil RJ Darvesh AS | 2013 | J Nutr Biochem2013，24，1： | 1 |
| 7 | Anthocyanin-rich black currant ( Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats显示文摘 | Anupam Bishayee Thomas Mbimba Roslin J. Thoppil Erzsébet Háznagy-Radnai Péter Sipos Altaf S. Darvesh Hans G. Folkesson Judit Hohmann | 2011 | The Journal of Nutritional Biochemistry2011，，11： | 1 |
| 8 | Disinfecting the iPad : e- valuating effective methods 显示文摘 | Howell V Thoppil A Mariyaselvam M | 2014 | J Hosp Infect2014，87，2： | 1 |
| 9 | Disinfecting the iPad: evaluating effective methods显示文摘 | Howell V Thoppil A Mariyaselvam M | 2014 | J Hosp Infect2014，87，2： | 1 |
| 10 | Pomegranate -mediated chemoprevenlion of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms 显示文摘 | Bishayee A Bhatia D Thoppil RJ | 2011 | Carcinogenesis2011，32，： | 1 |
| 11 | Persian Gulf response to a winter- time shamal wind event显示文摘 | THOPPIL P G HOGAN P J | 2010 | Deep Sea Research Part I:Oceano- graphic Research Papers2010，57，8： | 1 |
| 12 | Trimetazidine:Stability indicating RPLC assay method 显示文摘 | Thoppil SO Amin PD | 2001 | J Pbarm Biomed Anal2001，25，2： | 1 |
| 13 | Trimetazidine: stability indicating RPLC assay method显示文摘 | Thoppil SO Amin PD | 2001 | J Pharm Biomed Anal2001，25，2： | 1 |
| 14 | Antimicrobial activity of the essential oil of Lantana camara显示文摘 | Deena M J Thoppil J E | 2000 | Fitoterapia2000，71，： | 1 |
| 15 | Chemical composition and mosquito larvicidal activities of Salvia essential oils显示文摘 | Mathew J Thoppil J E | 2011 | Pharaceutical Biology2011，49，5： | 1 |
| 16 | Pomegranate bioactive constituents suppress cell proliferation and induce apoptosis in an experimental model of hepatocellular carcinoma: role of Wnt/ 13-Catenin signaling pathway显示文摘 | Bhatia D Thoppil ILl Mandal A | 2013 | Evid Based Complement Altemat Med2013，，37： | 1 |
| 17 | Dietary phytochemicals in the chemoprevention and treatment of hepatocellular carcinoma: in vivo evidence, molecular targets, and clinical relevance 显示文摘 | Bishayee A Thoppil R J Waghray A | 2012 | Curr Cancer Drug Targets2012，12，9： | 1 |
| 18 | Energetics of a global ocean circulation model compared to observations显示文摘 | Thoppil Prasad G. Richman James G. Hogan Patrick J | 2011 | Geophysical Research Letters2011，，15： | 1 |
| 19 | Antimicrobial activi- ty of Teucrium plectranthoides Gamble essential oil 显示文摘 | Thoppil JE Minija J Tajo A | 2001 | J Nat Reme2001，1，7： | 1 |
| 20 | Pomegranate-mediated che- moprevention of experimental hepatocarcinogenesis involves Nrf2- regulated antioxidant mechanisms 显示文摘 | Bishayee A Bhatia D Thoppil R J | 2011 | Carcinogenesis2011，32，6： | 1 |
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