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| 1 | Shanghai Score: A Prognostic and Adjuvant Treatment-evaluating System Constructed for Chinese Patients with Hepatocellular Carcinoma after Curative Resection显示文摘 | Hui-Chuan Sun Lu Xie Xin-Rong Yang Wei Li Jian Yu Xiao-Dong Zhu Yong Xia Ti Zhang Yang Xu Bo Hu Li-Ping Du Ling-Yao Zeng Jian Ouyang Wei Zhang Tian-Qiang Song Qiang Li Ying-Hong Shi Jian Zhou Shuang-Jian Qiu Qian Liu Yi-Xue Li Zhao-You Tang Yu Shyr Feng Shen Jia Fan | 2017 | Chinese Medical Journal2017，，22： | 15 |
| 2 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 3 | Inhibition of corneal fibrosis by Smad7 in rats after photorefractive keratectomy显示文摘 | WANG Ti ZHOU Xing-tao YU Yan ZHU Jing-yin DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2013 | Chinese Medical Journal2013，，8： | 8 |
| 4 | Expression of Smad7 inhibits fibrogenic responses of keratocytes to transforming growth factor β2显示文摘背景转变生长因素(TGF ) 是在纤维变性的发展的最重要的生长因素之一并且在角膜上结疤。Smad7,禁止的 Smad,能禁止 TGF 信号办理。在最近的年里,一些机关上的纤维变性的抑制上的调停 lentiviral 的 Smad7 的效果被学习了,当很少在角膜上对效果被知道时。试图在 TGF 2 在 vitro.Methods Keratocytes 导致的 keratocyte 增长和纤维变性上决定调停 lentiviral 的 Smad7 基因表示的效果的这研究从与表示 lentiviral 向量(Lv-Smad7 ) 或非工作的控制向量(Lv 空白) 的 Smad7 从 Sprague-Dawley (SD ) 老鼠和 transfected 孤立的 comeal 织物是有教养的。跟随暴露到 TGF2, keratocytes 被处理让 immunoblotting 估计 TGF/Smad 发信号的 Smad2 同样下游的事件的 phosphorylation。fibrotic 标记的表示光滑的肌肉肌动朊(-SMA), 类型骨胶原(骨胶原) 被西方的弄污和量的实时聚合酶链反应(PCR ) 测量。全面房间增长被 3-(4,5-dimethyl-thiazol-2-yl ) 决定 -2,5-dipheny1tetrazolium 溴化物(MTT ) 试金和房间的表示在 Smad7 基因转移压制了 TGF/Smad 由 Smad2 的下面调整的 phosphorylation 在 keratocytes 发信号的 mRNA 和蛋白质 levels.Results 的周期相关的标记 Ki67。包括 Ki67 的房间增长和纤维变性的标记, -SMA, 骨胶原被 Smad 7 的介绍禁止进 TGF 暴露的 keratocytes。因而,房间增长的率是 attenuated.Conclusion Smad7 基因转移到 TGF2 的 keratocytes 的禁止的 fibrogenic 回答。 | WANG Ti ZHOU Xing-tao YU Yan DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2011 | Chinese Medical Journal2011，，13： | 6 |
| 5 | A PILOT TRIAL FOR SEVERE ,REFRACTORY SYSTEMIC AUTOIMMUNE DISEASE WITH STEM CELL TRANSPLANTATION显示文摘Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy (HDIT) and autolo- gous hemopoietic stem cell transplantation (HSCT) with CD34+ cell selection in patients with severe, refractory autoim- mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjgren’s syndrome (pSS), or systemic sclerosis (SSc) who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Results Overall treatment related mortality was 7.7% (2/26) with 1 patient died of cytomegalovirus infection and an- other of severe pneumonia. Relapse occurred in 3 SLE patients (17.6%) in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index (SLEDAI) scores of SLE survivors decreased significantly (P < 0.01). RA patients recorded a drop of Disease Activity Score 28 (DAS 28). The pSS patient remained symptoms free up to now, more than 50 months after the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients. | Xiao-mei Leng Yan Zhao Dao-bing Zhou Huifen Situ Tai-sheng Li Ti Shen Yong-qiang Zhao Xiao-feng Zeng Feng-chun Zhang Yi Dong Fu-lin Tang | 2005 | Chinese Medical Sciences Journal2005，20，3： | 4 |
| 6 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 7 | Production of Embryogenic Callus and Plant Regeneration from Elite Guizhou Waxy Maize Inbred Lines显示文摘Immature embryos from three elite Guizhou waxy maize inbred lines (W21019, B7, and QCL5036) were evaluated for their ability of forming callus and regeneration into plants. Immature embryos harvested at different physiological stages were used as explants to initiate callus on N6 basal medium with 0-3.5 mg L-1 of 2,4-dichlorophenoxy acetic acid (2,4-D). The concentration of 2,4-D, physiological age of immature embryos and genotype had a significant effect (P<0.05) on the percentage of embryogenic callus formed. The optimum 2,4-D concentration for the initiation of embryogenic callus was varied among the waxy maize genotypes from 2.0 mg L-1 (B7 and QCL5036) to 3.0 mg L-1 (W21019). The shoots were generated from embryogenic callus which were transferred into the regeneration medium supplemented with 0-2.5 mg L-1 of 6-benzylaminopurine (6-BA). 6-BA in the medium significantly promoted the regeneration of embryogenic callus. Embryogenic size was also an important factor that affected regeneration capacity. 0.6-0.7 cm was proved to be the best size for regeneration from embryogenic callus and the mean number of shoots per primary callus in all genotypes achieved the highest number. The ability of the plant regeneration was also affected by genotype. W21019 had the highest number of shoots formed per primary embryogenic callus. With the optimum condition, the highest mean number of shoots per primary callus was up to 12.13, 5.73, and 3.33 in line W21019, B7, and QCL5036, respectively. The successful regeneration of the two inbred lines provides a basis for development of genetic transformation to improve priority traits such as enhanced insects and drought tolerance. | ZHONG De-yi ZHU You-yin LIU qian ZHOU ti ZHAO De-gang | 2011 | Agricultural Sciences in China2011，10，4： | 2 |
| 8 | Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells显示文摘 | Ti Zhang Hui-Chuan Sun Hong-Yuan Zhou Jing-Tao Luo Bai-Lin Zhang Peng Wang Lu Wang Lun-Xiu Qin Ning Ren Sheng-Long Ye Qiang Li Zhao-You Tang | 2009 | Cancer Letters2009，，2： | 1 |
| 9 | Modeling and Verifying Time Sensitive Security Protocols with Constraints显示文摘 | Zhou Ti Li Mengjun Li Zhoujun | 2008 | Electronic Notes in Theoretical Computer Science2008，212，： | 1 |
| 10 | Pharmacokinetic and toxicity study of an intraocular cyclosporine DDS in the anterior segment of rabbit eyes显示文摘 | Theng JT Ti SE Zhou L | 2003 | Invest Ophthalmol Vis Sci2003，44，11： | 1 |
| 11 | 龟兹汉佉二体钱的新发现显示文摘近二十年来在新疆维吾尔自治区发现的钱币表明和田汉佉二体钱值得重新审视。在喀什地区发现的3000枚汉佉二体钱,极大地增加了这一系列钱币的总数。最近发现的新的汉佉二体钱品种是在和田以外的地区发行的。这对研究公元前几世纪中亚史极为重要。 | 任宇红(译) 任威豪(译) Zhou Ti Mitsuda Norifumi Chris Liu | 2022 | 中国钱币2022，，4： | 1 |
| 12 | Oxidative ress affects cytoskeletal ructure and cell-matrix teractions in cells from an ocular ssue:the trabecular meshwork显示文摘 | st st in ti Ce Zhou L Li Y Yue BY | 1999 | 11Physiol1999，180，： | 1 |
| 13 | IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver显示文摘Endoplasmic reticulum(ER)stress is involved in ischemic preconditioning that protects various organs from ischemia/reperfusion(I/R)injury.We established an in vivo ER stress preconditioning model in which tunicamycin was injected into rats before hepatic I/R.The hepatic I/R injury,demonstrated by serum aminotransferase level and the ultra-structure of the liver,was alleviated by administration of tunicamycin,which induced ER stress in rat liver by activating inositol-requiring enzyme1(IRE1)andupregulating78 kDaglucose-regulated protein(GRP78).The proteomic identification for IRE1 binders revealed interaction and cooperation among receptor for activated C kinase 1(RACK1),phosphorylated AMPK,and IRE1 under ER stress conditions in a spatiotemporal manner.Furthermore,in vitro ER stress preconditioningwas induced by thapsigargin and tunicamycin in L02 and Hep G2 cells.Surprisingly,BCL2 was found to bephosphorylated by IRE1 under ER stress conditions to prevent apoptotic process by activation of autophagy.In conclusion,ER stress preconditioning protects against hepatic I/R injury,which is orchestrated by IRE1-RACK1 axis through the activation of BCL2.Our findings provide novel insights into the molecular pathways underlying ER stress preconditioning-elicited cytoprotective effect against hepatic I/R injury. | Dong Liu Xing Liu Ti Zhou William Yao Jun Zhao Zhigang Zheng Wei Jiang Fengsong Wang Felix O.Aikhionbare Donald L.Hill Nerimah Emmett Zhen Guo Dongmei Wang Xuebiao Yao Yong Chen | 2016 | Journal of Molecular Cell Biology2016，8，2： | 1 |
| 14 | Modeling and performance analysis using extended fuzzy-timing Petri nets for networked virtual environments显示文摘 | ZHOU Y MURATA T DEFAN TI T | 2000 | IEEE Transactions on System Man and Cybernetics-Part B:Cybernetics2000，30，5： | 1 |
| 15 | Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing显示文摘 | Chang CM Wu TI Zhou SM | 2001 | Circulation2001，103，： | 1 |
| 16 | Influence of aeration on microbial polymers and membrane fouling in submerged membrane bioreactors 显示文摘 | Lei Ji Zhou Ji ti | 2006 | Journal of Membrane Science2006，276，： | 1 |
| 17 | Factors associated with hypotension and bradyeardia after carotid angioplasty and stenting显示文摘 | Lin PH Zhou W Huynh TI' | 2007 | J Vasc Surg2007，46，5： | 1 |
| 18 | A multicenter, blinded, randomized, factorial controlled trial of doxycyeline and rifampin for treatment of Alzheimerrs disease: the DARAD trial 显示文摘 | MolloyDW Standish TI Zhou Q | 2013 | Int J Geriatr Psychiatry2013，28，： | 1 |
| 19 | United membrane biological reactor in the treatment of wastewater显示文摘The united membrane biological reactor(UMBR) was studied for the treatment of some simulate and municipal wastewater. The removal efficiency for COD and turbidity are greater than 80% and 99% respectively. Effluent COD is less than 100 mg/L while turbidity less than 5 The removal of LAS in bath wastewater is greater than 70%. In treatment of dinning hall wastewater, removal of fatty oil is greater than 90%, and its concentration in effluent is less than 5 mg/L. The match of biological reactor and the membrane separation component were calculated. The stable performance of wastewater treatment can be maintained by the optimization of operation conditions and the cleanout of membranes. | ZHOU Ji ti 1, YAN Bin 1* , DU Cui hong 1 , DONG Xiao li 1,2 (1 Environmental Engineering Institute, Dalian University of Technology, Dalian 116012, China. 2 Dalian Institute of Light Industry, Dalian 116034, China) | 2003 | Journal of Environmental Sciences2003，15，5： | 1 |
| 20 | Surgical management of non-parasitic hepatic cyst with biliary communication: a case report显示文摘Non-parasitic hepatic cysts with biliary communication are rare. The clinical symptoms involved are not specific to this condition, thereby making diagnosis difficult and treatment controversial. Here, we report a case of 70-year-old woman complaining of abdominal satiety, combined with non-specific pain in the right upper quadrant. The abdominal contrast-enhanced MRI-scan revealed a large and thick-walled septus cystic lesion in the liver. During operation, the biliary fistula was confirmed in the cyst cavity. A silica gel tube was inserted via the cystic duct for cholangiography, which demonstrated communication between the cyst and biliary tract. We performed wide-scale cyst wall resection; the biliary fistula was completely repaired by the closure of communicated bile ducts. The postoperative course was uneventful, and the patient was discharged with no sign of cholangitis or any other symptoms. The novel surgical management via wide resection of the cyst wall and closure of biliary communication proved to be an adequate and effective procedure for treating nonparasitic hepatic cysts with biliary communication. | Wei Cui Hong-Yuan Zhou Yan-Hui Zhang Ti Zhang Qiang Li | 2013 | Cancer Biology & Medicine2013，10，2： | 1 |
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