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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Conrtast-enhanced MR imaging of the facial nerve in 11 patients with Bell's palsy显示文摘 | Tien R Dillon WP Jackler RK | 1990 | AJNR1990，11，： | 1 |
| 3 | Development of a sutureless dural substitute from Bombyx mori silk fibroin显示文摘 | Flanagan KE Tien LW Elia R | 2015 | J Biomed Mater Res B Appl Biomater2015，103，3： | 1 |
| 4 | Fr-ontoethmoidal giant cell reparative granuloma显示文摘 | FELSBERG G J TIEN R D MCLENDON R E | 1995 | AJNR Am J Neuroradiol1995，16，： | 1 |
| 5 | Formation of perfused, functional microvascular tubes in vitro 显示文摘 | Chrobak K M Potter D R Tien J | 2006 | Microvasc Res2006，71，3： | 1 |
| 6 | Risk of varices bleeding after spleen-preserving distal panereatectomy with excision of splenic artery and vein 显示文摘 | TIEN Y W LIU K L HU R H | 2010 | Ann Surg Oncol2010，17，8： | 1 |
| 7 | Oxidation of thianthrene by the ligninase of Phanerochaete chrysosporium 显示文摘 | SCHREINER R P STEVENS J R TIEN M | 1988 | Applied and Environmental Microbiology1988，54，7： | 1 |
| 8 | MR fat suppression combined with Gd-DTPA enhancement in optic neuritis and perineuritis显示文摘 | TIEN R D OLESEN J SIMON J H | 1991 | J Comput Assist Tomogr1991，15，： | 1 |
| 9 | Trajectory analysis of deep- bed filtration with the sphere-in-cell porous media model 显示文摘 | Rajagopalan R Tien C | 1976 | A I Ch E Journal1976，22，3： | 1 |
| 10 | Chorea-ballismus with nonketotic hyperglycemia in primary diabetes mellitus显示文摘 | Lai P H Tien R D Chang M H | 1996 | AJNR1996，17，6： | 1 |
| 11 | Supported bilayer lipid membranes as ion and molecular probes 显示文摘 | Tien H T Barish R H Gu L Q | 1998 | Analytical Sicences1998，14，： | 1 |
| 12 | Integration of Artificial Neu-ral Network and MADA Methods for Green Supplier Se-lection 显示文摘 | Kuo R Wang Y Tien F | 2010 | Journal of Cleaner Production2010，18，51： | 1 |
| 13 | Trajectory analysis of deep bed filtration with the sphere-in-cell porous media model显示文摘 | Rajagopalan R Tien C | 1976 | American Institute of Chemical Engineering1976，22，： | 1 |
| 14 | Reversal of Allergen-induced Airway Remodeling by CysLT1 Receptor Blockade显示文摘 | Henderson W R Jr Chiang G K Tien Y T | 2006 | Am J Respir Crit Care Med2006，173，7： | 1 |
| 15 | Recent developments in microscale thermophysical engineering 显示文摘 | ABRAMSON A R TIEN C L | 1999 | Microscale Thermophys Eng1999，3，： | 1 |
| 16 | SiC-reinforced aluminum metal matrix composites显示文摘 | Tien J K Bates R C | 1985 | International Materials Reviews1985，30，6： | 1 |
| 17 | Phase transitions in the system BaTiO3-KNbO3显示文摘 | Bratton R J Tien T Y | 1967 | J Am Ceram Soc1967，50，2： | 1 |
| 18 | Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade 显示文摘 | Henderson W R Jr Chiang G K Tien Y T | 2006 | Am J Respir Crit Care Med2006，173，7： | 1 |
| 19 | Mesenchymal chondrosarcoma of the maxilla: case report and literature review 显示文摘 | Tien N Chaisuparat R Fernandes R | 2007 | J Oral Maxillofac Surg2007，65，6： | 1 |
| 20 | A bulk polymerization of styrene in a static mixer 显示文摘 | Tien N K Flaschel E R | 1985 | Chem Eng Comm1985，36，： | 1 |
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