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| 1 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 2 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 3 | Genetics and biochemistry of anthocyanin biosynthesis显示文摘 | Timothy A Holton and Edwina C | 1995 | The Plant Cell1995，，7： | 1 |
| 4 | Evolving space-filling curves to distribute radial basis functions over an inputspace显示文摘 | Timothy D C | 1994 | IEEE Transactions on Neural Networks1994，5，： | 1 |
| 5 | In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes显示文摘 | Janice A Niklas J Patrick O' Neill Timothy C Hunter | 1991 | Mutat Res1991，250，： | 1 |
| 6 | Evolving space filling curves to distribute radial basis functions over an in- put space 显示文摘 | Bruce A W Timothy D C | 1994 | IEEE Transactions on Neural Net- works1994，，5： | 1 |
| 7 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 8 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 9 | Velocity structure of a bottom simulating reflector offshore Peru:Results from full waveform inversion显示文摘 | Ingo A Timothy A Singh S C | 1996 | Earth and Planetary Letters1996，139，3： | 1 |
| 10 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 11 | Nomenclature of natural orifice translumenal endoscopic surgery ( NOTESTM ) and Laparoendoscopic single-site surgery (LESS) produres in urology 显示文摘 | Geoffrey B Timothy A Jeffrey C | 2008 | J Endourol2008，22，11： | 1 |
| 12 | The ultra high resolution XUV spectroheliograph 显示文摘 | WALKER A B C LINDBLOM J F TIMOTHY J G | 1990 | Optical Engineering1990，29，7： | 1 |
| 13 | An improved generalized Amber force field(GAFF)for urea显示文摘 | GUL A O WOLFGANG P TIMOTHY C | 2010 | Journal of Molecular Modeling2010，16，9： | 1 |
| 14 | Holmium laser percutaneous nephrolithotomy using a unique suction device显示文摘 | David C C Timothy D A | 2004 | J Endourol2004，18，： | 1 |
| 15 | Nano Li4Ti5O12-LiMn2O4 batteries with high power capability and improved cycle-life显示文摘 | Pasquier A D Huang C C Timothy S | 2009 | Journal of Power Sources2009，186，2： | 1 |
| 16 | Analysis of septic morbidity folliwing gunshot wounds to Colon:the missile is an adjuvant for abscess显示文摘 | Poret HA Timothy C Martin A | 1991 | J Trauma1991，31，8： | 1 |
| 17 | Architecture and stratigraphy of alluvial deposits,Morrison Formation(Upper Jurassic),Utah显示文摘 | Audun V K Edwin R S Timothy A C | 2008 | AAPG Bull2008，92，8： | 1 |
| 18 | IBM's S/390 G5 microprocessor design显示文摘 | Timothy J S Robert M Mark A C | 1999 | Micro IEEE1999，19，2： | 1 |
| 19 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 20 | Evaluation of WHO criteria for identifying patients with severe acute respiratory syndrome out -of- hospital: prospective observational study显示文摘 | Timothy H R Peter A C Devilliers S | 2003 | BMJ2003，326，21： | 1 |
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