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| 1 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 5 | CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer ) PCR primer design 显示文摘 | Timothy M Rose Jorja G Henikoff Steven Henikoff | 2003 | Nucleic Acids Research2003，31，13： | 1 |
| 6 | Firm,Strategic Group,and Industry Influences on Performance显示文摘 | Jeremy C Short David J Ketchen JR Timothy B Palmer G Tomas M Hult | 2007 | Strategic Management Journal2007，28，： | 1 |
| 7 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 8 | Suboptimal Minimum Cluster Volume Cover-Based Method for Measuring Fractal Dimension显示文摘 | Charles R T Timothy R M David J G | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，25，1： | 1 |
| 9 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 10 | Dynamic stability ofa microgrid with an active load 显示文摘 | Bottrell N Prodanovic M Timothy C G | 2013 | IEEE Transactions onPower Electronics2013，28，11： | 1 |
| 11 | Long invasive mechanieal ventilation support-weaning ratio survival and nonivasive ventilation in COPD of acute respiratory failure显示文摘 | Timothy G Pilswortha S John M | 2006 | Chest2006，129，： | 1 |
| 12 | Treatment of heart failure guided by plasma aminoterminal brain na- triuretic peptide( N-BNP ) concentrations 显示文摘 | Richard W Troughton Christopher M Frampton Timothy G Yandle | 2000 | The Lancet2000，355，9210： | 1 |
| 13 | Oat and rye tolerance to mesosulfuron and tribenuron显示文摘 | Andrew W M Culpepper A S Timothy L G | 2007 | Weed Tech- nology2007，214，： | 1 |
| 14 | Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats显示文摘 | Mason Tracy G | 1999 | Diabetes1999，48，： | 1 |
| 15 | Comparative approaches for assessing network vulnerability显示文摘 | Tony H G Timothy C M Alan T M | 2008 | International Regional Science Review2008，31，1： | 1 |
| 16 | Robust speaker recognition in noisy conditions 显示文摘 | Ji M Timothy J H James R G | 2007 | IEEE Transactions on Audio Speech and Language Processing2007，15，5： | 1 |
| 17 | Ma- ternal separation as a model of brain-gut axis dysfunction 显示文摘 | Siobhain M O' Mahony Niall P Hyland Timothy G | 2011 | Psychopharmacology2011，214，1： | 1 |
| 18 | Material estimation with terahertz time-domain spectroscopy显示文摘 | TIMOTHY D D RICHARD G B DANIEL M M | 2001 | Journal of Optical Society of America A2001，18，7： | 1 |
| 19 | Treating myocardial ischemia -reperfusion injury by targeting endothelial cell transcription显示文摘 | Edward M Boyle JR Timothy G | 1999 | Ann Thorac Surg1999，68，5： | 1 |
| 20 | 17 β-estradiol acts directly on the clonal osteoblastic cell line UMR 106显示文摘 | GRAY T K TIMOTHY C F KATHLEEN M G | 1987 | Proc Natl Acad Sci1987，84，17： | 1 |
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