|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 2 | VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis显示文摘尽管 VEGFR-3 缺乏破坏血脉管的开发在早 embryogenesis 期间,内在的机制不是清楚的。在 angiogenesis 和 lymphangiogenesis 描绘它的函数,我们在这研究雇用了二个遗传上修改的鼠标模特儿,与一个 inactivation 点变化(Vegfr3TKmut ) 为 ligand 有约束力的域(Vegfr3 螖 L BD ) 或酷氨酸 kinase 域指向编码区域。我们证明淋巴的生长在 Vegfr3 螖 L BD/螖 L BD 和 Vegfr3TKmut/TKmut 老鼠被破坏,但是血容器在胚胎和蛋黄囊通常发展了。有趣地在 Vegfr3 螖 L BD/螖 L BD 然而并非 Vegfr3TKmut/TKmut 老鼠,淋巴囊是在场的,但是有发芽的 lymphangiogenic 的缺乏。我们进一步证明 VEGFR-3 的野类型、变异的形式能与 VEGFR-2 形成 heterodimers,并且减少在 endothelial 房间的 phospho-VEGFR-2 和下游的 phospho-Erk1/2 的水平当他们与 VEGF 被对待时 -- 一。这些调查结果显示发信号由它的血缘的 ligands (VEGF-C/-D ) 经由 VEGFR-3 激活调停了没为 angiogenesis 被要求,并且那 VEGFR-3 可以由 modulating VEGFR-2-mediated 信号在这个过程起一个作用。 | Luqing Zhang Fei Zhou Wencan Han Bin Shen Jincai LUO Masabumi Shibuya Yulong He | 2010 | Cell Research2010，20，12： | 7 |
| 3 | Clinical significance of white gastric crypt openings observed via magnifying endoscopy显示文摘AIM:To evaluate the relationship between Helicobacter pylori(H.pylori)-induced gastritis and white gastric mucosal crypt openings(COs)in the gastric corpus.METHODS:A total of 175 consecutive patients(including 69 patients with gastric cancer)were enrolled in this study.We used magnifying endoscopy(ME)to observe the mucosa microsurface of the lesser and greater curvature of the gastric corpus(350 areas in all).We focused on areas with a round pit microstructure(primarily observed in non-atrophied areas)and evaluated the white openings of these gastric pits.We classified the whiteness of the COs as the'white-edged dark spot'type(consisting of a dark spot bordered by white);the'white'type(pure white with no dark spot);and the'dense white pit(DWP)'type(dense white,resembling a snowball).Gastritis was also histologically evaluated according to the updated Sydney System.RESULTS:We detected round COs using ME in 246 of the 350 areas examined.The histological examination showed significantly more mononuclear cells and neutrophil infiltration in the'white'and'DWP'types than the'white-edged dark spot'type(P<0.001).Furthermore,significantly high-grade inflammation and evidence of active H.pylori-induced gastritis was observed in the'DWP'type(P<0.001).Significant differences were observed in the whiteness of COs between H.pylori-positive(n=139)and negative(n=36)patients(P<0.001).The sensitivity and specificity of the'white'and'DWP'types for predicting H.pylori infection were78.5%and 81.7%,respectively.Of the patients with gastric cancer,22.5%(18/80)had'white-edged dark spots',51.3%(41/80)had'white'COs,and 26.3%(21/80)had'DWP'-type COs.'DWPs'were frequently observed among patients with undifferentiated gastric cancer[45.7%(16/35)].CONCLUSION:CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation and H.pyloriinduced activity. | Masashi Kawamura Hitoshi Sekine Shu Abe Daisuke Shibuya Katsuaki Kato Takayuki Masuda | 2013 | World Journal of Gastroenterology2013，19，48： | 7 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 5 | Biliary tuberculosis causing cicatricial stenosis after oral anti-tuberculosis therapy显示文摘与黑暗的尿和黄巩膜介绍的一个 36 岁的菲律宾的女人。内视镜后退 cholangiopancreatography (ERCP ) 证实了肝内胆汁管的膨胀并且也在肝核显示出普通的肝的管的不规则的苛评。从胆汁管的活体检视的组织学的检查揭示了上皮状的房间风湿性肉芽肿和干酪样坏死。小块茎杆菌然后在胆汁测试的聚合酶链反应(PCR ) 上被检测,给胆汁的肺结核的诊断。尽管微生物痊愈被证实,病人开发了肝的管的 cicatricial。她与内视镜的胆汁的排水(EBD ) 经历了重复治疗试管和经皮的 transhepatic 胆汁的排水(PTBD ) 试管,和狭窄在 6 年以后被改正。我们在场有结节的胆汁的苛评的一个盒子,从更普通的恶意要求小心的区别并且由于处理以后的 cicatricial 的风险需要长期的后续的一个条件,尽管它是稀罕的。 | Tomohisa Iwai Mitsuhiro Kida Yoshiki Kida Nobuaki Shikama Akitaka Shibuya Katsunori Saigenji | 2006 | World Journal of Gastroenterology2006，12，30： | 6 |
| 6 | Transnasal endoscopic retrograde chalangiopancreatography using an ultrathin endoscope: A prospective comparison with a routine oral procedure显示文摘AIM: To investigate if transnasal endoscopic retrograde cholangiopancreatography (n-ERCP) using an ultrathin forward-viewing scope may overcome the disadvantages of conventional oral ERCP (o-ERCP) related to the large- caliber side-viewing duodenoscope. METHODS: The study involved 50 patients in whom 25 cases each were assigned to the o-ERCP and n-ERCP groups. We compared the requirements of esophagogastroduodenoscopy (EGD) prior to ERCP, rates and times required for successful cannulation into the pancreatobiliary ducts, incidence of post-procedure hyperamylasemia, cardiovascular parameters during the procedure, the dose of a sedative drug, and successful rates of endoscopic naso-biliary drainage (ENBD). RESULTS: Screening gastrointestinal observations were easily performed by the forward-viewing scope and thus no prior EGD was required in the n-ERCP group. There was no significant difference in the rates or times for cannulation, or incidence of hyperamylasemia between the groups. However, the cannulation was relatively difficult in n-ERCP when the scope appeared U-shape under fluoroscopy. Increments of blood pressure and the amount of a sedative drug were significantly lower in the n-ERCP group. ENBD was successfully performed succeeding to the n-ERCP in which mouth-to-nose transfer of the drainage tube was not required. CONCLUSION: n-ERCP is likely a well-tolerable methodwith less cardiovascular stress and no need of prior EGD or mouth-to-nose transfer of the ENBD tube. However, a deliberate application is needed since its performance is difficult in some cases and is not feasible for some endoscopic treatments such as stenting. | Akihiro Mori Noritsugu Ohashi Takako Maruyama Hideharu Tatebe Katsuhisa Sakai Takashi Shibuya Hiroshi Inoue Shoudou Takegoshi Masataka Okuno | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 7 | Factors associated with incomplete colonoscopy at a Japanese academic hospital显示文摘AIM:To evaluate significant risk factors for incomplete colonoscopy at a Japanese academic hospital.METHODS:A total of 11812 consecutive Japanese people were identified who underwent a colonoscopy at an academic hospital.A multiple logistic regression model was used to evaluate retrospectively the significant risk factors for incomplete colonoscopy.RESULTS:The cecal intubation rate was 95.0%.By univariate analysis,age,female sex,poor bowel cleansing,and a history of abdominal or pelvic surgery were significant risk factors for incomplete colonoscopy(P<0.001).Moreover,age-and sex-adjusted analysis showed that significant risk factors for incomplete colonoscopy were female sex(OR=1.38,95%CI:1.17-1.64,P=0.0002),age≥60 years old(OR=1.44,95%CI:1.22-1.71,P<0.0001),a history of prior abdominal or pelvic surgery(OR=1.55,95%CI:1.28-1.86,P<0.0001),poor bowel cleansing(OR=4.64,95%CI:3.69-5.84,P<0.0001),and inflammatory bowel disease(IBD)(OR=1.48,95%CI:1.13-1.95,P=0.0048).In Japanese men,by age-adjusted analysis,IBD(OR=1.69,95%CI:1.18-2.43,P=0.005)was an independent risk factor for incomplete colonoscopy.CONCLUSION:Several characteristics in the Japanese population were identified that could predict technical difficulty with colonoscopy. | Shigeo Koido Toshifumi Ohkusa Kosaburo Nakae Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi Arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri | 2014 | World Journal of Gastroenterology2014，20，22： | 6 |
| 8 | Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis显示文摘AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same sites.WLI images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic features.Likewise,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color model.WLI and AFI endoscopic scores from the same sites were compared.Histological evaluation of biopsies was according to the Riley Index.RESULTS:Relative to red(r=0.52,P<0.01)or blue(r=0.56,P<0.01)color component,the green color component of AFI(r=-0.62,P<0.01)corresponded more closely with mucosal inflammation sites.There were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P<0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P<0.01).The WLI scores for 'vascu-lar patterns'(r=-0.65,P<0.01),'edema'(r=-0.62,P<0.01),histology scores for 'polymorphonuclear cells in the lamina propria'(r=-0.51,P<0.01)and 'crypt architectural irregularities'(r=-0.51,P<0.01)showed correlation with the green color component of AFI.There were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within MES-0.As the severity of the mucosal inflammation increased,the green color component of AFI decreased.The AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of UC.CONCLUSION:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images. | Taro Osada Atsushi Arakawa Naoto Sakamoto Hiroya Ueyama Tomoyoshi Shibuya Tatsuo Ogihara Takashi Yao Sumio Watanabe | 2011 | World Journal of Gastroenterology2011，17，46： | 5 |
| 9 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 10 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 11 | Seasonal variations in the onset of ulcerative colitis in Japan显示文摘AIM:To investigate seasonal variations in the onset and relapse of ulcerative colitis(UC)in Japanese patients.METHODS:Between 1994 and 2006,198 Japanese patients diagnosed with UC according to conventional criteria in an academic hospital were enrolled for onset evaluation.Among 265 Japanese patients with UC who were observed for more than 12 mo,165 patients relapsed(239 times)and were enrolled for relapse evaluation.The patients’symptoms were recorded each month for 12 consecutive years.RESULTS:There was monthly seasonality in symptom onset during October and March for UC.The onset of symptoms in UC patients frequently occurred during the winter.Variation in UC onset was observed according to both month(P=0.015)and season(P=0.048).Relapse commonly occurred in October,and variations in relapse were not significant either in month(P=0.52)or season(P=0.12).Upper respiratory inflammation was the main factor responsible for relapse.CONCLUSION:Our results suggest that environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan. | Shigeo Koido Toshifumi Ohkusa Hiroaki Saito Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi Arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，47： | 3 |
| 12 | Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreaticcancer显示文摘 | Makoto Abue Misa Yokoyama Rie Shibuya Keiichi Tamai Kazunori Yamaguchi Ikuro Sato Nobuyuki Tanaka Shin Hamada Tooru Shimosegawa Kazuo Sugamura Kennichi Satoh | 2015 | International Journal of Oncology2015，，2： | 3 |
| 13 | Multi-temporal monitoring of wheat growth by using images from satellite and unmanned aerial vehicle显示文摘Recently near-ground remote sensing using unmanned aerial vehicles(UAV)witnessed wide applications in obtaining field information.In this research,four Rapideye satellite images and eight RGB images acquired from UAV were used from early June to the end of July,2015 covering two experimental winter wheat fields,in order to monitor wheat canopy growth status and analyze the correlation among satellite images based normalized difference vegetation index(NDVI)with UAV’s RGB images based visible-band difference vegetation index(VDVI)and ground variables of the sampled grain protein contents.Firstly,through image interpretation of UAV’s multi-temporal RGB images with fine spatial resolution,the wheat canopy color changes could be intuitively and clearly monitored.Subsequently,by monitoring the changes of satellite images based NDVI as well as VDVI values and UAV’s RGB images based VDVI values,the conclusions were made that these three vegetation indices demonstrated the same and synchronized trend of increasing at the early stage of wheat growth season,reaching up to peak values at the same timing,and starting to decrease since then.The results of the correlation analysis between NDVI of satellite images and sampled grain protein contents show that NDVI has good predicative capability for mapping grain protein content before ripening growth stage around June7,2015,while the reliability of using satellite image based NDVI to predict grain protein contents becomes worse as ripening stage approaches.The regression analysis between UAV’s RGB image based VDVI and satellite image based VDVI as well as NDVI showed good coefficients of determination.It is concluded that it is feasible and practical to temporally complement satellite remote sensing by using UAV’s RGB images based vegetation indices to monitor wheat growth status and to map within-field spatial variations of grain protein contents for small scale farmlands. | Du Mengmeng Noguchi Noboru Itoh Atsushi Shibuya Yukinori | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 3 |
| 14 | Radiotherapy for primary localized(stage Ⅰ and Ⅱ) non-Hodgkin's lymphoma of the oral cavity显示文摘 | Sunaba K Shibuya H Okada N | 2000 | Radiat Oncol Biol2000，47，1： | 2 |
| 15 | Regulation of catecholamine synthesis by Leptin显示文摘 | Shibuya I Utsunomiya K ToyohI-Ra Y | 2002 | Ann N Y Acad Sci2002，971，52： | 2 |
| 16 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 17 | Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis显示文摘 | Masabumi Shibuya Lena Claesson-Welsh | 2005 | Experimental Cell Research2005，，5： | 2 |
| 18 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 19 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 20 | JNK contributes to temozolomide resistance of stem-like glioblastomacells via regulation of MGMT expression显示文摘 | Masashi Okada Atsushi Sato Keita Shibuya Eriko Watanabe Shizuka Seino Shuhei Suzuki Manabu Seino Yoshitaka Narita Soichiro Shibui Takamasa Kayama Chifumi Kitanaka | 2014 | International Journal of Oncology2014，，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员