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| 1 | Liver transplantation: Current status and challenges显示文摘Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greater use of liver allografts following donation after cardiac death(DCD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DCD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function. | Caroline C Jadlowiec Timucin Taner | 2016 | World Journal of Gastroenterology2016，22，18： | 23 |
| 2 | Revisiting the liver’s role in transplant alloimmunity显示文摘The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation.This phenomenon was observed nearly five decades ago.Subsequently,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart.The liver has a unique architecture and is home to many cells involved in immunity and inflammation.After transplantation,these cells migrate from the liver into the recipient.Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system.Recent studies on human T-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation.In this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses. | Nitin Abrol Caroline C Jadlowiec Timucin Taner | 2019 | World Journal of Gastroenterology2019，25，25： | 2 |
| 3 | Antibody‐mediated rejection in liver transplantation: Current controversies and future directions显示文摘 | Timucin Taner Mark D. Stegall Julie K. Heimbach | 2014 | Liver Transpl2014，，5： | 1 |
| 4 | Decreased chronic cellular and antibody-mediated injury in the kidney following simultaneous liver-kidney transplantation显示文摘 | Timucin Taner Julie K. Heimbach Charles B. Rosen Scott L. Nyberg Walter D. Park Mark D. Stegall | 2015 | Kidney International2015，，： | 1 |
| 5 | Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence显示文摘This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation.This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages.Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis,and recent evidence suggests that chronic inflammation precedes fibrosis. | Mathew George Philippe Paci Timucin Taner | 2020 | World Journal of Gastroenterology2020，26，17： | 0 |
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