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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Preparation and properties of a new coating method for preparing conductive polyester fibers with permanent conductivity显示文摘 | Tin X Xiao C F An S L | 2006 | J Appl Polym Sci2006，1029，3： | 1 |
| 3 | Automatic test data generation for path testing using GAS显示文摘 | J C Tin P L Yeh | 2001 | Information Science2001，131，1： | 1 |
| 4 | Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft显示文摘 | Tin M M Cho C H Chan K | 2007 | Carcinogenesis2007，28，13： | 1 |
| 5 | Clinial features of nipah virusencephalitis among pig farmers in Malaysia显示文摘 | Jin G K Tin T C Kong C N | 2000 | New England Joural of Medicine2000，17，： | 1 |
| 6 | Novel design of gaits on space station for dynamic disturbance minimization 显示文摘 | Wing K C Qian H H Tin L L | 2014 | IEEE/ ASME Transactions on Mechatronics2014，19，4： | 1 |
| 7 | Chance-type flexiondistraction injurirs in the thoracolumbar spine : MR imaging characteristies 显示文摘 | Groves C J Cassar-Pullicino VN Tins B J | 2005 | Radiology2005，236，2： | 1 |
| 8 | Effect of Ru on the high temperature phase stability of Ni-base single crystal superalloys 显示文摘 | YEH A C TIN S | 2006 | Metallurgical and Materials Transactions A2006，37，： | 1 |
| 9 | Heat transfer mechanisms during short-pulse laser heating of metals显示文摘 | Qiu T Q Tin C L | 1993 | Journal of Heat Transfer1993，115，： | 1 |
| 10 | Heat transfer mechanisms during shortpulse laser heating of metals显示文摘 | QIU T Q TIN C L | 1993 | ASME J Heat Transfer1993，115，： | 1 |
| 11 | The effect of ruthenium on the intermediate to high temperature creep response of high refractory content single crystal suepralloy 显示文摘 | HOBBS R A ZHANG L RAE C M F TIN S | 2008 | Materials Science and Engineering A2008，489，： | 1 |
| 12 | Probiotic Lactoba- cillus rhamnosus GG enhanced Thl cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model 显示文摘 | WEN K TIN C WANG H F | 2014 | PLoS One2014，9，94： | 1 |
| 13 | Femto-second laser heating of multi-layer metals-Ⅰ analysis显示文摘 | Qiu T Q Tin C L | 1994 | Int Heat Mass Transfer1994，37，： | 1 |
| 14 | Probiotic Laotobacillus rhamno- sus GG enhanced Thl cellular immunity but did not affect anti- body responses in a human gut mierobiota transplanted neonatal gnotobiotie pig model 显示文摘 | Wen K Tin C Wang H | 2014 | PIoS One2014，9，4： | 1 |
| 15 | Improved inversion channel mobility for 4H-SiC MOSFETs following high temperature anneals in nitric oxide显示文摘 | CHUNG G Y TIN C C WILLIAMS J R | 2001 | IEEE Electron Devives Letters2001，22，4： | 1 |
| 16 | Polyimide-carbonized membranes for gas separation: Structural, composi- tion, and morphological control of precursors显示文摘 | Tin P S Xiao Y C Chung T S | 2007 | Sep Purif Rev2007，35，： | 1 |
| 17 | A castability model based onelemental solid-liquid partitioning in advanced nickel-base single-crystal superalloys 显示文摘 | HOBBS R A TIN S RAE C M F | 2005 | Metallurgical and Materials Transactions A2005，36，27： | 1 |
| 18 | Sorghum phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution显示文摘 | Lo?c Lepiniec Eliane Keryer Herve Philippe Pierre Gadal Claude Crétin | 1993 | Plant Molecular Biology1993，，3： | 1 |
| 19 | Stress inducible transcription factor chopz' gdd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms显示文摘 | May tin E V Ubeda M LinJ C | 2001 | Exp Cell Res2001，267，2： | 1 |
| 20 | Complete nucleotide sequence of a sorghum gene coding for the phosphoenolpyruvate carboxylase involved in C4 photosynthesis显示文摘 | Lo?c Lepiniec Eliane Keryer Denis Tagu Pierre Gadal Claude Crétin | 1992 | Plant Molecular Biology1992，，2： | 1 |
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