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| 1 | Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent显示文摘Bioabsorbable magnesium alloys are widely studied for various implant applications, as they reduce the risks such as severe inflammatory response existing in permanent metallic implants. However, the overfast corrosion rate of magnesium alloy is usually an obstacle in biomedical applications. Here we report a simple two-step reaction to introduce anticorrosive silane pre-treatment on Mg Zn YNd alloys before coating with poly(glycolide-co-lactide)(PLGA). The first step is to immerse the NaO H-activated MgZ nY Nd with bistriethoxysilylethane(BTSE) to form a cross-linked silane coating layer with enhanced corrosion resistance; the second step involves immobilizing amine functional groups for forming hydrogen bond with outer PLGA coating by treating the BTSE-modified MgZnYNd with 3-amino-propyltrimethoxysilane(APTES). We characterized the BTSE-APTES pre-treated PLGA coating on MgZnYNd by scanning electron microscopy(SEM), Fourier transform infrared spectroscopy(FT-IR), X-ray photoelectron spectroscopy(XPS),static contact angle and Acid Orange 7 measurement. Nano-scratch test was to verify that the scratch resistance of the PLGA coating with BTSE-APTES pre-treatment was superior to direct PLGA coating. Standard electrochemical measurements along with the long-term immersion results indicated that the BTSEAPTES pre-treatment rendered better in vitro degradation behavior. Cell adhesion and cell viability tests with both vascular smooth muscle cells(VSMC) and human umbilical vein endothelial cells(EA. hy926)demonstrated that BTSE-APTES pre-treated MgZnYNd substrate had significantly more beneficial effects.The favorable anti-corrosion behavior and biocompatibility of BTSE-APTES pre-treated PLGA coatings on MgZnYNd alloy suggest that the novel two-step silanization procedure may have the great potential to enhance the performance of the magnesium-based biomaterials and provide a valid solution for the conversion modification of cardiovascular implants, taking the magnesium-based bioabsorbable materials closer to clinical application. | Jing Liu Tingfei Xi | 2016 | Journal of Materials Science & Technology2016，32，9： | 10 |
| 2 | Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment显示文摘The Mg-Zn-Y-Nd alloy is a new type of degradable material for biomedical application. In the present study, Mg-6Zn-1.2Y-0.8Nd alloy was fabricated, and then extrusion and heat treatment were conducted to optimize its mechanical properties and cytocompatibility. The microstructure observation, mechanical property, degradation behavior and cytocompatibility tests were conducted on the Mg-Zn-Y-Nd alloy with three different states: as-cast(alloy C), as-extruded(alloy E) and extruded + heat treated(alloy EH).The results show that alloy C consists of coarse grains and continuous secondary phases. The extrusion process has caused incomplete recrystallization, and results in a mixed grain structure of elongated grains and small equiaxed grains(alloy E). The heat treatment process has promoted the recrystallization and homogenized the grain structure(alloy EH). Both the strength and ductility of the alloy has been improved by extrusion, but the following heat treatment has decreased the strength and increased the ductility.The degradation behavior of the alloy C and E alloys does not show much difference, but improves slightly in alloy EH, because the heat treatment has homogenized the microstructure and released the residual stress in the alloy. The directly and indirectly cell viability tests indicate that alloy EH exhibits the best cytocompatibility, which should be ascribed to its relative uniform degradation and low ion releasing rate. In summary, the combination of hot extrusion and heat treatment could optimize the mechanical property and cytocompatibility of the Mg-Zn-Y-Nd alloy together, which is beneficial for the future application of the alloy. | Yiyuan Kang Beining Du Yueming Li Baojie Wang Liyuan Sheng Longquan Shao Yufeng Zheng Tingfei Xi | 2019 | Journal of Materials Science & Technology2019，35，1： | 8 |
| 3 | Multifunctional MgF_2/Polydopamine Coating on Mg Alloy for Vascular Stent Application显示文摘Mg alloy is of great potential in the application of vascular stent due to its degradation in physical environment and proper mechanical property.However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation.Besides,in order to accelerate the reendothelialization of Mg-based stents,it needs surface modification to improve the attachment,growth and adhesion of endothelial cells(ECs).To solve the main obstacles,an anti-corrosion and quick endothelialization coating was prepared on novel Mg-Zn-Y-Nd alloy via a simple two-step immersion method in the present study,first in hydrofluoric acid(HF) then in dopamine tris-Hydrochloric acid(tris-HC1) solution.The coating was uniform and thin,which consisted of two layers—the upper was polydopamine(PDA) layer and the lower was MgF_2 layer.The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test.Moreover the HFPDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation.The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells(VSMCs),which was preferable for re-endothelialization.The results suggest that HF-PDA-treated Mg-Zn-Y-Nd alloy has great potential in the application of vascular stent and the surface coating method is of great application value in biodegradable Mg alloy stent due to its simplicity and effectiveness. | Xiaoli Liu Zhen Zhen Jing Liu Tingfei Xi Yudong Zheng Shaokang Guan Yufeng Zheng Yan Cheng | 2015 | Journal of Materials Science & Technology2015，31，7： | 8 |
| 4 | In Vitro Study on Mg-Sn-Mn Alloy as Biodegradable Metals显示文摘The mechanical properties,chemical properties and biocompatibility of Mg-3Sn—0.5Mn alloy were tested.A series of in vitro evaluations such as tensile test,static and dynamic immersion test,hemocompatibility test as well as cytotoxicity test were presented,with commercial magnesium alloy WE43 as the control.Mg-3Sn-0.5Mn alloy possesses suitable strength and superior ductility compared with WE43 and AZ31.Static immersion and dynamic degradation tests showed more uniform degradation with a more moderate rate for Mg—3Sn—0.5Mn alloy(0.34 mm/y in static condition and 0.25 mm/y in dynamic condition)compared with WE43 alloy(0.42 mm/y in static condition and 0.33 mm/y in dynamic condition) in Hank's solution.Blood compatibility evaluation suggested that Mg—3Sn—0.5Mn alloy had no destructive effect on erythrocyte and showed excellent anti-thrombogenicity to blood system.Besides,Mg—3Sn—0.5Mn alloy showed no inhibition effect to L929 metabolic activity and mild toxicity to vascular smooth muscle cell(VSMC) in preliminary cell viability assessment.By considering its excellent mechanical strength,corrosion resistance,low ion release rate and good biocompatibility,Mg—3Sn—0.5Mn alloy may be a promising economical candidate as biomedical implant material for load-bearing clinical applications in the future. | Zhen Zhen Tingfei Xi Yufeng Zheng Li Li Lugee Li | 2014 | Journal of Materials Science & Technology2014，30，7： | 6 |
| 5 | Cupric ion release and cytotoxicity for Yuangong Cu-IUDs and the release behavior of indomethacin for medicated 220 Cu-IUD显示文摘These years Yuangong copper-bearing intrauterine devices (Cu-IUDs) have been used because of less side effects in use. The corrosion of copper is essential to the success of contraception, and the release behavior of indomethacin from medicated Cu-IUD is related to its therapeutic effect. In this study, analytical methods were established to investigate the release behavior of cupric ion of three kinds of Yuangong Cu-IUDs and indomethacin of medicated Yuangong 220 Cu-IUD. Cu-IUDs were incubated in simulated uterine solution (SUS). The concentrations of cupric ion and indomethacin were analyzed by flame atomic absorption spectrometer (FAAS) for 60 days and UV/vis ?3310 spectrophotometer for 60 days, respectively. The morphology of copper after corrosion was characterized by SEM. In addition, we detected cytotoxicity by MTT of L929 mouse fibroblasts cells caused by extracts of the three Yuangong Cu-IUDs. The release behavior of cupric ion for three kinds of Yuangong Cu-IUDs was biphasic, which consisted of the initial burst release and then slow and constant release. In vitro release experiment confirmed a biphasic release of indomethacin from Yuangong 220. The copper wire of Yuangong Cu-IUDs showed uneven corrosion. The RGR value of Yuangong 365 Cu-IUD was smaller than that of medicated Yuangong 220 Cu-IUD and RGR value of medicated Yuangong 220 Cu-IUD was smaller than that of Yuangong 300 Cu-IUD. The cupric ion release and indomethacin release showed biphasic. Indomethacin increased the cupric ion release rate and might diminish the adverse effects caused by burst release of cupric ion. The toxicity grade of these three Yuangong Cu-IUDs was 4. We should canvass the adverse events of Cu-IUDs based on practical experiments, and try our best to reduce the toxicity of Cu-IUDs. | CAO BianMei XI TingFei ZHENG YuDong YANG LiFeng ZHENG Qi | 2009 | Chinese Science Bulletin2009，54，18： | 6 |
| 6 | Characterization of decellularized scaffold derived from porcine meniscus for tissue engineering applications显示文摘 | Shuang GAO Zhiguo YUAN Tingfei XI Xiaojuan WEI Quanyi GUO | 2016 | Frontiers of Materials Science2016，10，2： | 3 |
| 7 | Effect of extrusion process on the mechanical and in vitro degradation performance of a biomedical Mg-Zn-Y-Nd alloy显示文摘A new type of biomedical Mg-Zn-Y-Nd alloy was developed and thermal extruded by different processes to investigate the effect of extrusion ratio and extrusion pass on its microstructure,mechanical property and degradation performance.The results show that the increase of extrusion ratio could promote the dynamic recrystallization(DRX)process and led to the coarsening of DRXed grains.While the increase of extrusion pass also contributes to the DRX process but refines the DRXed grains.The simultaneous increasing of extrusion ratio and extrusion pass refines the secondary phases obviously.The increase of extrusion ratio has reduced the tensile strength but improved the elongation of the alloy significantly.However,the increase of extrusion pass could enhance the tensile strength and elongation simultaneously,especially the strength.The degradation performance has been optimized effectively through increasing the extrusion ratio and extrusion pass. | Beining Du Ziyang Hu Jiali Wang Liyuan Sheng Hui Zhao Yufeng Zheng Tingfei Xi | 2020 | Bioactive Materials2020，5，2： | 3 |
| 8 | Biological effect and molecular mechanism study of biomaterials based on proteomic research显示文摘Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tests and cellular experiments stay on the phenomenon description instead of mechanism interpretation, the development of proteomics technologies provides a golden opportunity to uncover the molecular interaction mechanism between biomaterial-organism on whole scale. This review summarizes current application of proteomics in biological effect and mechanism study of biomaterials, and discusses the development and challenges for future studies. | Zhen Zhen Yufeng Zheng Zigang Ge Chen Lai Tingfei Xi | 2017 | Journal of Materials Science & Technology2017，33，7： | 1 |
| 9 | In vitro study of endothelial cells lining vascular grafts grown within the recipient ' s peritoneal cavity 显示文摘 | Zhang Zhixiong Xi Tingfei Wang Yingjun | 2008 | Tissue engineering Part A2008，14，6： | 1 |
| 10 | Release behavior of cupric ions for TCu380A and TCu220C IUDs显示文摘 | Bianmei Cao Tingfei Xi Yudong Zheng | 2008 | Biomed Mater2008，3，4： | 1 |
| 11 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Xuenan Gu Yufeng Zheng Yan Cheng Shengping Zhong Tingfei Xi | 2008 | Biomaterials2008，，4： | 1 |
| 12 | Microstructure, precipitates and compressive properties of various holmium doped NiAl/Cr(Mo,<ce:hsp sp='0.25'/>Hf) eutectic alloys显示文摘 | Liyuan Sheng Lijun Wang Tingfei Xi Yufeng Zheng Hengqiang Ye | 2011 | Materials and Design2011，，10： | 1 |
| 13 | In Vitro Comparative Effect of Three Novel Borate Bioglasses on the Behaviors of Osteoblastic MC3T3-E1 Cells显示文摘Most related investigations focused on the effects of borate glass on cell proliferation/biocompatibility in vitro or bone repair in vivo;however,very few researches were carried out on other cell behaviors.Three novel borate bioglasses were designed as scaffolds for bone regeneration in this wok.Comparative effects of three bioglasses on the behaviors of osteoblastic MC3T3-E1 cells were evaluated.Excellent cytocompatibility of these novel borate bioglasses were approved in this work.Meanwhile,the promotion on cell proliferation,protein secretion and migration with minor cell apoptosis were also discussed in details,which contributed to the potential clinical application as a new biomaterial for orthopedics. | Xiaojuan Wei Tingfei Xi Yufeng Zheng Changqing Zhang Wenhai Huang | 2014 | Journal of Materials Science & Technology2014，30，10： | 1 |
| 14 | Corrosion of, and cellular responses to Mg–Zn–Ca bulk metallic glasses显示文摘 | Xuenan Gu Yufeng Zheng Shengping Zhong Tingfei Xi Junqiang Wang Weihua Wang | 2009 | Biomaterials2009，，6： | 1 |
| 15 | Microstructure, precipitates and compressive properties of various holmium doped NiAl/Cr(Mo,Hf) eutectic alloys显示文摘 | Liyuan Sheng Lijun Wang Tingfei Xi Yufeng Zheng Hengqiang Ye | 2011 | Materials and Design2011，，： | 1 |
| 16 | Influence of the extraction parameters on the cytotoxicity test results of Mg materials显示文摘Recently more and more researchers query the predictability of cytotoxicity results of biomedical Mg alloys obtained according to ISO 10993 due to significant difference between in vitro and in vivo corrosion. This study aimed to observe the influence of different extraction parameters(time, volume/surface ratio and medium composition) on cytotoxicity results and illustrate whether more predictable results could be obtained by adjusting the extraction parameters. The results showed that longer extraction time and smaller extraction volume/surface ratio improve the sensitivity of screening Mg materials by making inferior Mg materials release relatively more ions to the extract; and more predictable results could not be obtained by the way of simply adding bovine serum albumin(BSA) into the extraction medium to the same level in vivo or simply using fetal bovine serum(FBS) directly as extraction medium, since BSA and FBS accelerated the corrosion of Mg materials during extraction and they affected the cells' health states during the test. In order to get more predictable results, in our opinions, it is necessary to establish a database of primary cells' hazards(metal ions, p H and H2gas) tolerance and a set of in vitro corrosion test with high similarity in vivo, which is very difficult to realize now however. | Xiaoli Liu Tingfei Xi Yudong Zheng | 2014 | Progress in Natural Science:Materials International2014，24，5： | 1 |
| 17 | In vitro corrosion and biocompatibility of binary magnesium alloys显示文摘 | Xuenan Gu Yufeng Zheng Yan Cheng Shengping Zhong Tingfei Xi | 2008 | Biomaterials2008，，4： | 1 |
| 18 | A high-throughput study on endothelial cell adhesion and growth mediated by adsorbed serum protein via signaling pathway PCR array显示文摘The purpose of this paper is to utilize the signaling pathway polymerase chain reaction(PCR)arrays to investigate the activation of two important biological signaling pathways in endothelial cell adhesion and growth mediated by adsorbed serum protein on the surface of bare and titanium nitride(TiN)-coated nickel titanium(NiTi)alloys.First,the endothelial cells were cultured on the bare and TiN-coated NiTi alloys and chitosan films as control for 4 h and 24 h,respectively.Then,the total RNA of the cells was collected and the PCR arrays were performed.After that,the differentially expressed genes in the transforming growth factor beta(TGF-b)signaling pathway and the regulation of actin cytoskeleton pathway were screened out;and the further bioinformatics analyses were performed.The results showed that both TGF-b signaling pathway and regulation of actin cytoskeleton pathway were activated in the cells after 4 h and 24 h culturing on the surface of bare and TiN-coated NiTi alloys compared to the chitosan group.The activated TGF-b signaling pathway promoted cell adhesion;the activated regulation of actin cytoskeleton pathway promoted cell adhesion,spreading,growth and motility.In addition,the activation of both pathways was much stronger in the cells cultured for 24 h versus 4 h,which indicated that cell adhesion and growth became more favorable with longer time on the surface of two NiTi alloy materials. | Xiaoying Lü Yayun Qu Ying Hong Yan Huang Yiwen Zhang Dayun Yang Fudan Zhang Tingfei Xi Deyuan Zhang | 2018 | Regenerative Biomaterials2018，5，1： | 1 |
| 19 | A Novel Material for the Coating of Artificial Heart Valve显示文摘A TioO2-x/TiN multilayer film was synthesized by ion beam enhanced deposition to modify the properties of material for artificial heart valve (AHV). The blood compatibility of the film was evaluated by clotting time measurement, platelet adhesion test, hemolysis analysis and protein adsorption experiment. The investigation on mechanical properties including fatigue life, wear resistance and adhesion strength between AHV material matrix and the film were carried out. the results revealed a significant improvement of blood compatibility of AHV material by the film coating, and the high level of mechanical properties have also been demonstrated. The synthesized film shows a promising of more desirable AHV material. | Xi Tingfei Huang Nan Tian Wenhua Yang Ping Leng Yongxiang Cheng Xiang Liu Xianghuai(1 ) Center of Medical Device, National Institute for Control of Pharmaceotical and Biological Products, Beijing, 100050, China2) Department of Materials Engineering, | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，4： | 0 |
| 20 | THE INFLUENCE OF MACROMOLECULES ON FIBRINOGEN COAGULANILITY显示文摘THEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYTHEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYWangChunren;YangZib... | Wang Chunren Yang Zibin Lu Songfang Xi Tingfei (Institute of Basic Medicine,PUMC,CAMS & Beijing 100005 China) (National institute for the Control of Pharmaceutical andBiological Products,Beijing 100050 China)Ma Weiyuan ( Department of Medical Physi | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
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