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| 1 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 2 | Palliative surgery for unresectable pancreatic and periampullary cancer: a reappraisal显示文摘 | Mickael Lesurtel M.D. Nidal Dehni M.D. Emmanuel Tiret M.D. Rolland Parc M.D. Fran?ois Paye M.D. Ph.D | 2006 | Journal of Gastrointestinal Surgery2006，，2： | 3 |
| 3 | TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study 显示文摘 | Morange PE Tiret L Saut N | 2004 | EurJ HumGenet2004，12，12： | 1 |
| 4 | Evidence from combined converting emzyme (ACE) gene controles plasma ACE level 显示文摘 | TIRET L RIGAT B VISIKIS B | 1992 | Am J Hum Genet1992，51，： | 1 |
| 5 | Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS) 显示文摘 | Humphries SE Nicaud V Margalef J Tiret L Talmud PJ | 1998 | Arterioscler Thromb Vasc Biol1998，18，4： | 1 |
| 6 | Evidence from combined segregation and linkage analysis, that a variant of the angiotensin I - converting enzyme (ACE) gene eontrols plasma ACE levels 显示文摘 | Tiret L | 1992 | Am J Hum Genet1992，51，1： | 1 |
| 7 | Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease显示文摘 | Tiret L Godefroy T Lubos E | 2005 | Circulation2005，112，5： | 1 |
| 8 | Long-term functional outcome after low anterior resection: comparison of low colorectal anastomosis and colonic J-pouch-anal anastomosis显示文摘 | Dehni N Tiret E Singland JD | 1998 | Dis Colon Rectum1998，41，： | 1 |
| 9 | Rectal cancer: ESMO clinical practice guidelines for diagnosis, treat- ment and follow-up显示文摘 | Glimelius B Tiret E Cervantes A | 2013 | Ann Oncol2013，24，6： | 1 |
| 10 | Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up 显示文摘 | Glimelius B Tiret E Cervantes A | 2013 | Ann Oncol2013，24，6： | 1 |
| 11 | Synergistic effects of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphism on risk of myocardial infarction显示文摘 | TIRET L BONNARDEAUX A POIRIER O | 1994 | Lancet1994，344，： | 1 |
| 12 | Interleukin-18 is a strong predictor of cardiovascular death in stable and nstable angina显示文摘 | Blankenberg S Tiret L Bickel C | 2002 | Circulation2002，106，1： | 1 |
| 13 | Palliative surgery for unreaeetable pancreatic and periampullary cancer:a reappraisal显示文摘 | Lesurtel M Dehni N Tiret E | 2006 | J Gastrointest Surg2006，10，2： | 1 |
| 14 | Ultralow anterior resection with intersphincteric dissection-what is the limit of safe sphincter preservation显示文摘 | Tiret E Poupardin B McNamara D | 2003 | Colorectal Dis2003，5，5： | 1 |
| 15 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 16 | Evidence,from combined segregation and linkage analysis,that a variant of the angiotensin Ⅰ-converting enzyme (ACE)gene controls plasma ACE levels显示文摘 | TIRET L RIGAT B VISVIKIS S | 1992 | Am J Hum Genet1992，51，1： | 1 |
| 17 | Evidence,from combined segregation and linkage analysis, that a variant of the angiotensin Ⅰ-converting enzyme (ACE) gene controls plasma ACE levels 显示文摘 | TIRET L RIGAT B VISVIKIS S | 1992 | Am J Hum Genet1992，51，1： | 1 |
| 18 | Evidence,form combined segregation and linkage analysis,that a variant of the angiotensin 1-converting enzyme(ACE)gene controls plasma ACE levels显示文摘 | Tiret L Rigat B Visvikis S | 1992 | Am J Hum Cenet1992，51，： | 1 |
| 19 | GABA in the insula - a predictor of the neural response to interoceptive awareness显示文摘 | Wiebking C Duncan NW Tiret B | 2014 | Neuroimage2014，86，： | 1 |
| 20 | What is the Incidence of Metastatic Lymph Node Involvement After Significant Pathologic Response of Primary Tumor Following Neoadjuvant Treatment for Locally Advanced Rectal Cancer?显示文摘 | Hadrien Tranchart Jérémie H. Lefèvre Magali Svrcek Jean-Fran?ois Flejou Emmanuel Tiret Yann Parc | 2013 | Annals of Surgical Oncology2013，，5： | 1 |
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