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| 1 | Current status of ultrasound-guided surgery in the treatment of breast cancer显示文摘The primary goal of breast-conserving surgery(BCS) is to obtain tumour-free resection margins. Margins positive or focally positive for tumour cells are associated with a high risk of local recurrence, and in the case of tumour-positive margins, re-excision or even mastectomy are sometimes needed to achieve definite clear margins. Unfortunately, tumour-involved margins and re-excisions after lumpectomy are still reported in up to 40% of patients and additionally, unnecessary large excision volumes are described. A secondary goal of BCS is the cosmetic outcome and one of the main determinants of worse cosmetic outcome is a large excision volume. Up to 30% of unsatisfied cosm-etic outcome is reported. Therefore, the search for better surgical techniques to improve margin status, excision volume and consequently, cosmetic outcome has continued. Nowadays, the most commonly used localization methods for BCS of non-palpable breast cancers are wire-guided localization(WGL) and radioguided localization(RGL). WGL and RGL are invasive procedures that need to be performed pre-operatively with technical and scheduling difficulties. For palpable breast cancer, tumour excision is usually guided by tactile skills of the surgeon performing 'blind' surgery. One of the surgical techniques pursuing the aims of radicality and small excision volumes includes intraoperative ultrasound(IOUS). The best evidence available demonstrates benefits of IOUS with a significantly high proportion of negative margins compared with other localization techniques in palpable and non-palpable breast cancer. Additionally, IOUS is non-invasive, easy to learn and can centralize the tumour in the excised specimen with low amount of healthy breast tissuebeing excised. This could lead to better cosmetic results of BCS. Despite the advantages of IOUS, only a small amount of surgeons are performing this technique. This review aims to highlight the position of ultrasoundguided surgery for malignant breast tumours in the search for better oncological and cosmetic outcomes. | José H Volders Max H Haloua Nicole MA Krekel Sybren Meijer Petrousjka M van den Tol | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 2 | Molecular orientation in rubbed polyimide alignment layers used for liquid-crystal displays显示文摘 | van Aerie N A J M Tol A J W | 1994 | Macromolecule1994，27，： | 1 |
| 3 | Assciation of endothelial growth factor expression with tumor agiogenesis and with early relapse in primary breast cancer 显示文摘 | Tol M Hoshina D Takayanagi T | 1994 | Cancer Res1994，85，10： | 1 |
| 4 | Genomic characterization of the human DNA excision repair gene ERCC-1显示文摘 | van Duin M Koken MH van den Tol J | 1987 | Nucleic Acids Res1987，15，22： | 1 |
| 5 | A High Luminance High-resolution Cathode-ray Tube for Special Purposes 显示文摘 | Van Tol M W Esdonk J V | 1983 | IEEE Transaction on Electron Devices1983，3，3： | 1 |
| 6 | Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab显示文摘 | Tol J Dijkstra JR Klomp M | 2010 | Eur J Cancer2010，46，11： | 1 |
| 7 | Surgical experience in children with differentiated thyroid carcinoma 显示文摘 | HAVEMAN J W VAN TOL K M ROUWE C W | 2003 | Ann Surg Oncol2003，10，1： | 1 |
| 8 | Chemotherapy,bevacizum-ab, and cetuximab in metastatic colorectalcancer显示文摘 | Tol J Koopman M Cats A | 2009 | N Engl J Med2009，360，： | 1 |
| 9 | Possible economic impacts of a slowdown of the thermohaline circulation:an application of FUND显示文摘 | Tol R S J | 2004 | Portuguese Economic Journal2004，3，： | 1 |
| 10 | Markers for EGFRpath- way activation as predictor of outcome in metastaticcolorectal cancer patients treated with or withoutcetuximab 显示文摘 | Tol J Dijkstra JR Klomp M | 2010 | Eur J Cancer2010，46，： | 1 |
| 11 | Chemotherapy, beva-cizumab, and cetuximab in metastatic colorectal cancer显示文摘 | Tol J Koopman M Cats A | 2009 | N Engl J Med2009，360，6： | 1 |
| 12 | Chemotherapy, bevacizumab, and cetuximab in metastatic colorec- tal cancer显示文摘 | TOL J KOOPMAN M CATS A | 2009 | N Engl J Med2009，360，6： | 1 |
| 13 | A comparison of suture-repair with mesh-repair for incisional hernia 显示文摘 | Luijendijk RW Hop W Van Del Tol M | 2000 | NEJM2000，343，： | 1 |
| 14 | A randomised phase III study on capeeitabine, oxaliplatin and bevacizumab with or without cctuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG): An interim analysis of toxicity显示文摘 | Tol J Koopman M Rodenburg C J | | Ann Oncol0，19，4： | 1 |
| 15 | Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer显示文摘 | Tol J Koopman M Cats A | 2009 | New Engl J Med2009，360，6： | 1 |
| 16 | Effects of High-Frequency Cranial Electrostimulation on the Rest-Activity Rhythm and Salivary Cortisol in Alzheimer' s Disease显示文摘 | Scherder E Knol D van Tol M J | 2006 | Dementia and geriatric cognitive disorders2006，22，4： | 1 |
| 17 | Functional magnetic resonance imaging correlates of emotional word encoding and recognition in depression and anxiety disorders 显示文摘 | van Tol M J Demenescu LR van der Wee N J | 2012 | Bio| Psychiatry2012，71，7： | 1 |
| 18 | Chemotherapy, bevacizumab, and eetuximab in metastatic coloreetal cancer显示文摘 | Tol J Koopman M Cats A | 2009 | N Engl J Med2009，360，6： | 1 |
| 19 | A 3-dimensional primary production model(Bloom/Gem) and its application to the (southern) North Sea( Coupled physical-chemical-ecological model 显示文摘 | Los F J Villars M T Van tier Tol M W M | 2008 | Journal of Marine Systems2008，74，12： | 1 |
| 20 | Whole brain restingstate analysis reveals decreased functional connectivity in major depression显示文摘 | Veer I M Beckmann C F Van Tol M J | 2010 | Frontiers in systems neuroscience2010，4，： | 1 |
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