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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 3 | Apple dwarfing rootstocks exhibit an imbalance in carbohydrate allocation and reduced cell growth and metabolism显示文摘Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot mass.To identify physiological factors responsible for rootstock-induced growth restriction,we compared vascular-enriched gene expression between two dwarfing rootstocks(‘M27’and‘M9’)and the vigorous rootstock‘M793’using RNA sequencing and quantitative reverse transcriptase PCR.Differentially expressed genes common to both dwarfing rootstocks belonged to five main biological processes:(1)primary metabolism,(2)cell wall synthesis and modification,(3)secondary metabolism,(4)hormone signalling and response and(5)redox homeostasis.Genes promoting the biosynthesis of amino acids,lipids and cell walls were downregulated in dwarfing rootstocks,whereas genes promoting the breakdown of these compounds were upregulated.The only exception to this trend was the upregulation of starch synthesis genes in dwarfing rootstocks.Non-structural carbohydrate analysis demonstrated that starch concentrations in‘M9’roots,stems and grafted‘Royal Gala’(‘RG’)scions were double that of equivalent tissues from‘RG’homo-grafted trees(‘RG’/‘RG’).Fructose and glucose concentrations were much lower in all three tissues of the‘RG’/‘M9’trees.Together,these data indicate that dwarfing rootstocks are in a state of sugar depletion and reduced cellular activity despite having large starch reserves.Another significant finding was the over-accumulation of flavonoids and the downregulation of auxin influx transporters MdAUX1 and MdLAX2 in dwarfing rootstocks.We propose that both factors reduce polar auxin transport.The results of this study contribute novel information about the physiological state of dwarfing rootstocks. | Toshi M Foster Peter A McAtee Chethi N Waite Helen L Boldingh Tony K McGhie | 2017 | Horticulture Research2017，4，1： | 4 |
| 4 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | Pierre Le-Clech Vicki Chen Tony A G F | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 5 | From a traditional replenishment system to vendor managed inventory: a case study from the household electrical appliances sector显示文摘 | De Toni A F Zamolo E | 2005 | International Journal of Production Economics2005，96，1： | 1 |
| 6 | Use of miniscrews and miniplates in orthodontics 显示文摘 | Leung Michael Tat-Chi Lee Tony Cheuk-Kit Rabie A | 2008 | J Oral Maxillofac Surg2008，66，： | 1 |
| 7 | Neurological deterioration in acute ischemic stroke - Potentialpredictors and associated factors in the European Cooperative Acute Stroke Study (ECASS) I显示文摘 | Davalos A Toni D Iweins F | 1999 | Stroke1999，30，： | 1 |
| 8 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | PIERRE L C VICKI C TONY A G | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 9 | GeocenterMotions from GPS: A Unified Observation Model显示文摘 | David A’Lavalle'e Tonie van D | 2006 | Journal of Geophysical Research2006，111，05： | 1 |
| 10 | Use of a stress inducible promoter to drive ectopic AtCBF expression improves potato freezing tolerance while minimizing negative effects on tuber yield显示文摘 | María‐TeresaPino Jeffrey S.Skinner Eung‐JunPark ZoranJekni? Patrick M.Hayes Michael F.Thomashow Tony H. H.Chen | 2007 | Plant Biotechnology Journal2007，，5： | 1 |
| 11 | From a traditional replenishment system to vendor-managed inventory: A case study from the household electrical appliances sector显示文摘 | De Toni A Zamolo E | 2005 | International Journal of Production Economics2005，96，1： | 1 |
| 12 | Neurological deterioration in acute ischemic stroke:potential predictors and associated factors in the European cooperative acute stroke study (ECASS) I显示文摘 | Davalos A Toni D Iweins F | 1999 | Stroke1999，30，12： | 1 |
| 13 | Active contours with out edges 显示文摘 | Chan Tony F Vese Luminita A | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 14 | Buyer-supplier operational practices, sourcing policies and plant performances: results of an empirical research 显示文摘 | de Toni A Nassimbeni G | 1999 | International Journal of Production Research1999，37，9： | 1 |
| 15 | Characterization of a phenylalanine ammonia-lyase multigene family in Trifolium subterraneum显示文摘 | Paul A H Tony A Jeremy J W | 1994 | Gene1994，138，1： | 1 |
| 16 | Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance 显示文摘 | ZAID A TONY K SAMER E | 2004 | Pharmacol Ther2004，102，： | 1 |
| 17 | Applying coordinate transformations to multi-DOF shaker control显示文摘 | Underwood Marcos A Keller Tony | 2006 | Sound and Vibration2006，40，1： | 1 |
| 18 | Joint Watermarking Scheme for Multiparty Multilevel DRM Architecture显示文摘 | Tony Thomas Sabu Emmanuel Subramanyan A V | 2009 | IEEE Trans on lntormation Forensics and Security2009，4，： | 1 |
| 19 | Benchmarking least squares support vector machine classifiers显示文摘 | Gestel Tony Van Suykens J A K Baesens Bart | 2004 | Machine learning2004，54，1： | 1 |
| 20 | Active Contours Without Edges显示文摘 | TONY F CHAN LUMINITA A VESE | 2001 | IEEE Transactions on Image Processing Vol 10 No 22001，2001，： | 1 |
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