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| 1 | New approaches in the treatment of hepatitis C显示文摘About 130-170 million people, is estimated to be infected with the hepatitis C virus(HCV). Chronic HCV infection is one of the leading causes of liverrelated death and in many countries it is the primaryreason for having a liver transplant. The main aim of antiviral treatment is to eradicate the virus. Until a few years ago the only treatment strategy was based on the combination of pegylated interferon and ribavirin(PEG/RBV). However, in genotypes 1 and 4 the rates of viral response did not surpass 50%, reaching up to 80% in the rest. In 2011 approval was given for the first direct acting antiviral agents(DAA), boceprevir and telaprevir, for treatment of genotype 1, in combination with traditional dual therapy. This strategy managed to increase the rates of sustained viral response(SVR) in both naive patients and in retreated patients, but with greater toxicity, interactions and cost, as well as being less safe in patients with advanced disease, in whom this treatment can trigger decompensation or even death. The recent, accelerated incorporation since 2013 of new more effective DAA, with pan-genomic properties and excellent tolerance, besides increasing the rates of SVR(even up to 100%), has also created a new scenario: shorter therapies, less toxicity and regimens free of PEG/RBV. This has enabled their almost generalised applicability in all patients. However, it should be noted that most of the scientific evidence available is based on expert opinion, case-control series, cohort studies and phase 2 and 3 trials, some with a reduced number of patients and select groups. Few data are currently available about the use of these drugs in daily clinical practice, particularly in relation to the appearance of side effects and interactions with other drugs, or their use in special populations or persons with the less common genotypes. This situation suggests the need for the generalised implementation of registries of patients receiving antiviral therapy. The main inconvenience of these new drugs is their high cost. This necessitates selection and prioritization of candidate patients to receive them, via strategies established by the various national organs, in accordance with the recommendations of scientific societies. | rocío gonzález-grande miguel jiménez-pérez carolina gonzález arjona josémostazo torres | 2016 | World Journal of Gastroenterology2016，22，4： | 9 |
| 2 | Management of hepatitis B virus infection after liver transplantation显示文摘Chronic hepatitis B virus(HBV) infection is responsible for up to 30% of cases of liver cirrhosis and up to 53% of cases of hepatocellular carcinoma. Liver transplantation(LT) is the best therapeutic option for patients with end-stage liver failure caused by HBV. The success of transplantation, though, depends on receiving prophylactic treatment against post-transplant viral reactivation. In the absence of prophylaxis, liver transplantation due to chronic hepatitis B(CHB) is associated with high rates of viral recurrence and poor survival. The introduction of treatment with hepatitis B immunoglobulins(HBIG) during the 1990 s and later the incorporation of oral antiviral drugs have improved the prognosis of these patients. Thus, LT for CHB is now a universally accepted option, with an estimated 5 years survival of around 85% vs the 45% survival seen prior to the introduction of HBIG. The combination of lamivudine plus HBIG has for many years been the most widely used prophylactic regimen. However, with the appearance of new more potent oral antiviral agents associated with less resistance(e.g., entecavir and tenofovir) for the treatment of CHB, new prophylactic strategies are being designed, either in combination with HBIG or alone as a monotherapy. These advances have allowed for more personalized prophylaxis based on the individual risk profile of a given patient. In addition, the small pool of donors has required the use of anti-HBc-positive donors(with the resulting possibility of transmitting HBV from these organs), which has been made possible by suitable prophylactic regimens. | Miguel Jiménez-Pérez Rocío González-Grande José Mostazo Torres Carolina González Arjona Francisco Javier Rando-Mu?oz | 2015 | World Journal of Gastroenterology2015，21，42： | 3 |
| 3 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 4 | 西印度洋地区海草生态系统显示文摘海草是海洋被子植物,广泛分布在温带和热带的海岸带水域,是地球上水生生态系统中最具生产力的生物之一。在西印度洋地区大概有13种海草,这些海草覆盖了12000kg海岸线的近岸柔软海底广大区域。海草床一般分布在潮间带和潮下带,有时向下延伸至40m,并经常出现在珊瑚礁和红树林附近。由于具有很高的初级生产力和复杂的栖息环境,海草供养了许多底栖生物和浮游生物。许多鱼类和贝类,包括那些具有商业价值的种类都被吸引到海草栖息地,将海草作为其食物来源和避难场所,特别是在它们的幼年期。分布在西印度洋海草床附近广泛而丰富的鱼类资源就足以说明这一点。这些鱼分别属于天竺鲷科、亚科、玻甲鱼科、银鲈科、虾虎鱼科、隆头鱼科、裸颊鲷科、笛鲷科、单角亚科、鹦嘴鱼科、科、篮子鱼科、海龙科和Teraponidae科。因此,西印度洋地区的海草生态系统无论对当地还是整个地区的渔业发展都是非常有价值的资源。尽管如此,与其他地区相比,该地区有关海草资源的研究还十分缺乏,而且大多数研究也都集中在植物多样性和生态学上。本文主要阐述西印度洋地区海草床研究现状,特别强调鱼类和渔业。目前,该课题的大多数研究主要是在东非海岸开展的,如肯尼亚,坦桑尼亚,莫桑比克以及南非东部地区,而在索马里和西印度洋地区的岛屿国家(塞舌尔、科摩罗、法属留尼旺岛、毛里求斯、马达加斯加等)此类研究却很少,有关海草鱼类生态系统的论文也少有发表,而且大部分都是描述性的。因此,需要通过研究和实验获得有关描述模式和处理方法的科学知识。关于海草鱼类群落的定量研究,类似本文所介绍的案例研究在西印度洋地区是很少的,而这些研究对于渔业的管理前景而言是必不可少的。值得强调的是由于海岸人口的不断增长以及人类活动的侵扰给该地区海草床带来的压力与日俱增,如污染,海水富营养化,沉积作用,捕鱼以及无脊椎动物的采集等活动,而这些活动对于海草床的影响却鲜为人知。因此,需要开展广泛的研究,为西印度洋地区海草生态系统可持续管理提供有用的信息服务。 | Martin Gullstrm Maricela de la Torre Castro Salomo O.Bandeira Mats Bjrk Mattis Dahlberg Nils Kautsky Patrik Rnnbck Marcus C.hman 章任群 | 2002 | AMBIO-人类环境杂志2002，31，7： | 2 |
| 5 | Procalcitonin as a prognostic biomarker of severe sepsis and septic shock 显示文摘 | Azevedo JR Torres O J Czeczko NG | 2012 | Rev Col Bras Cir2012，39，6： | 1 |
| 6 | Contour salience descriptors for effective image retrieval and analysis显示文摘 | Torres R S and Falc?o A X | 2007 | Image Vision Computing2007，25，1： | 1 |
| 7 | Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS):the Brazilian experience 显示文摘 | Torres O J Femandes ES Oliveira CV | 2013 | Arq Bras Cir Dig2013，26，1： | 1 |
| 8 | Procalcito- nin as a prognostic biomarker of severe sepsis and septic shock 显示文摘 | AZEVEDO J R TORRES O J CZECZKO N G | 2012 | RevColBrasCir2012，39，6： | 1 |
| 9 | 显示文摘 | Filho O Torre L Hench L | 1996 | J Biomed Mater Res1996，30，4： | 1 |
| 10 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 11 | Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism显示文摘 | TORRES I O KUCHENBECKER K M NNADI C I | 2015 | Nat Commun2015，6，： | 1 |
| 12 | Ultraviolet-B radiation and nitrogen effects on growth and yield of maize under Mediterranean field conditions显示文摘 | CORREIA C M COUTINHO J F BJORN L O TORRES J M G | 2000 | European Journal of Agronomy2000，12，2： | 1 |
| 13 | Photoluminescence of Rhodamine 6G-doped amorphous TiO2 thin films grown by sol-gel 显示文摘 | PALOMINO M R TORRES K J LOZADA M R PORTILLO M O GARCIA R M ZELAYA A O | 2007 | Vacuum2007，81，1112： | 1 |
| 14 | Nutritional status of Helicobacter pylori-infected children in Guatemala as compared with uninfected peers显示文摘 | Quinonez JM Chew F Torres O | 1999 | Am J TropMed Hyg1999，61，3： | 1 |
| 15 | Bias dependence of FD Transistor respond to total dose irradiation 显示文摘 | Flament O Torres A Ferlet- Cavrois V | 2003 | IEEE Transactions of nuclear science2003，50，6： | 1 |
| 16 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 17 | Linear-nonlinear neuronal model for shape from shading显示文摘 | José R.A. Torre?o Jo?o L. Fernandes | 2011 | Pattern Recognition Letters2011，，9： | 1 |
| 18 | Electrophoretic mobility and stabilization of asphaltenes in low conductivity media 显示文摘 | Leo'n O Rogel E Torres G | 2000 | Petroleum Science & Technology2000，18，78： | 1 |
| 19 | Oxygen-induced maturation of SODI : a key role for disulfide formation by the copper chaperone CCS显示文摘 | Furukawa Y Torres A S O'Halloran T V | 2004 | EMBO J2004，23，14： | 1 |
| 20 | Potential prenatal predictions of Down syndrome:a statistical analysis显示文摘 | O'Brien WF Knuppel RA Torres C | 1990 | Am J Obstet Gynecol1990，163，： | 1 |
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