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| 1 | Trefoil factors:Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma显示文摘AIM:To investigate trefoil factor(TFF) gene copy number,mRNA and protein expression as potential biomarkers in cholangiocarcinoma(CCA).METHODS:TFF mRNA levels,gene copy number and protein expression were determined respectively by quantitative reverse transcription polymerase chain reaction(PCR),quantitative PCR and immunohistochemistry in bile duct epithelium biopsies collected from individuals with CCA,precancerous bile duct dysplasia and from disease-free controls.The functional impact of recombinant human(rh) TFF2 peptide treatment on proliferation and epidermal growth factor receptor(EGFR) /mitogenactivated protein kinase(MAPK) signaling was assessed in the CCA cell line,KMBC,by viable cell counting and immunoblotting,respectively.RESULTS:TFF1,TFF2 and TFF3 mRNA expression was significantly increased in CCA tissue compared to disease-free controls,and was unrelated to gene copy number.TFF1 immunoreactivity was strongly increased in both dysplasia and CCA,whereas TFF2 immunoreactivity was increased only in CCA compared to diseasefree controls.By contrast,TFF3 immunoreactivity was moderately decreased in dysplasia and further decreased in CCA.Kaplan-Meier analysis found no association of TFF mRNA,protein and copy number with age,gender,histological subtype,and patient survival time.Treatment of KMBC cells with rhTFF2 stimulated proliferation,triggered phosphorylation of EGFR and downstream extracellular signal related kinase(ERK),whereas co-incubation with the EGFR tyrosine kinase inhibitor,PD153035,blocked rhTFF2-dependent proliferation and EGFR/ERK responses.CONCLUSION:TFF mRNA/protein expression is indicative of CCA tumor progression,but not predictive for histological sub-type or survival time.TFF2 is mitogenic in CCA via EGFR/MAPK activation. | Kanuengnuch Kosriwong Trevelyan R Menheniott Andrew S Giraud Patcharee Jearanaikoon Banchob Sripa Temduang Limpaiboon | 2011 | World Journal of Gastroenterology2011，17，12： | 16 |
| 2 | Targeting STAT3 in gastric cancer显示文摘 | Andrew S Giraud Trevelyan R Menheniott Louise M Judd | 2012 | Expert Opinion on Therapeutic Targets2012，，9： | 3 |
| 3 | Lipoprotein lipase gene variants relate to presence and degree of microalbuminuria in type II diabetes显示文摘 | MATTU R K TREVELYAN J NEEDHAM E W | 2002 | Diabetologia2002，45，6： | 2 |
| 4 | QUADRATURE METHODS FOR HIGHLY OSCILLATORY SINGULAR INTEGRALS显示文摘We address the evaluation of highly oscillatory integrals,with power-law and logarithmic singularities.Such problems arise in numerical methods in engineering.Notably,the evaluation of oscillatory integrals dominates the run-time for wave-enriched boundary integral formulations for wave scattering,and many of these exhibit singularities.We show that the asymptotic behaviour of the integral depends on the integrand and its derivatives at the singular point of the integrand,the stationary points and the endpoints of the integral.A truncated asymptotic expansion achieves an error that decays faster for increasing frequency.Based on the asymptotic analysis,a Filon-type method is constructed to approximate the integral.Unlike an asymptotic expansion,the Filon method achieves high accuracy for both small and large frequency.Complex-valued quadrature involves interpolation at the zeros of polynomials orthogonal to a complex weight function.Numerical results indicate that the complex-valued Gaussian quadrature achieves the highest accuracy when the three methods are compared.However,while it achieves higher accuracy for the same number of function evaluations,it requires signi cant additional cost of computation of orthogonal polynomials and their zeros. | Jing Gao Marissa Condon Arieh Iserles Benjamin Gilvey Jon Trevelyan | 2021 | Journal of Computational Mathematics2021，39，2： | 1 |
| 5 | Optimism, Overconfidence and Entrepreneurial Activity显示文摘 | TREVELYAN R | 2008 | Management Decision2008，46，7： | 1 |
| 6 | Free-surface thin-film flows over uniformly heated topography显示文摘 | SAPRYKIN S TREVELYAN P M J KOOPMANS R J | 2007 | Phys Rev E2007，75，2： | 1 |
| 7 | Free-surface thin-film flows over uniformly heated topography显示文摘 | Saprykin S Trevelyan P M J Koopmans R J | 2007 | Physical Review E2007，75，02： | 1 |
| 8 | A two-dimensional isogeometric boundary element method for elastostatic analysis显示文摘 | SIMPSON R N BORDAS S P A TREVELYAN J | 2012 | Computer Methods in Applied Mechanics and Engineering2012，209，： | 1 |
| 9 | Development of an oral administration of oxytetracycline to control losses due to withering syndrome in cultured red abalone Haliotis rufescens显示文摘 | Friedman C S Trevelyan G Robbins T T | 2003 | Aquaculture2003，224，14： | 1 |
| 10 | Carcass disposal: Lessons from Great Britain following the foot and mouth disease out- breaks of 2001 显示文摘 | Scudamore J M Trevelyan G M Tas M V | 2002 | Rev Sci Tech Off Int Epiz2002，21，3： | 1 |
| 11 | Web-based telerobotics显示文摘 | Dalton B Trevelyan J | 1999 | Robotica1999，17，： | 1 |
| 12 | Remote Laboratories and Team Skills in Mechatronics显示文摘 | James Trevelyan | 2003 | Mechatronics and Machine Vision in Practice 2003 Conference Perth Western Australia2003，，： | 1 |
| 13 | Comparison of the effect of en-alapril and losartan in conjunction with surgical coronary revascularisation versus revascularisation alone on systemic endothelial function显示文摘 | Trevelyan J Needham EW Morris A | 2005 | Heart2005，91，： | 1 |
| 14 | Novel basis func- tions for the partition of unity boundary element meth- od for Helmholtz problems 显示文摘 | Peake M J Trevelyan J Coates G | 2013 | International Journal for Numerical Methods in Engineering2013，93，9： | 1 |
| 15 | Analysis of Stray Current Corrosion Problems using Boundary Element Method显示文摘 | TREVELYAN J HACK H P | 1994 | Boundary Element Technology IX1994，，： | 1 |
| 16 | Is eccentric exercise an effective treatment for lateral epicondylitis? A systematic review显示文摘 | Cullinane FL Boocock M G Trevelyan F C | 2014 | Clinical rehabilitation2014，28，1： | 1 |
| 17 | Lipoprotein lipase gene varants relate to presence and degree of microalbuminuria in type2 dia-betes显示文摘 | Mattu RK Trevelyan J Needham EW | 2002 | Diabetologia2002，45，6： | 1 |
| 18 | A two-dimensional isogeometric boundary element method for elastostatic analysis显示文摘 | SIMPSON R N BORDAS S P A TREVELYAN J | 2012 | Computer Methods in Applied Mechanics and Engineering2012，209，： | 1 |
| 19 | Use of discontinuous boundary elements for fracture mechanics analysis显示文摘 | | 1992 | Engineering Analysis with Boundary Elements1992，10，： | 1 |
| 20 | Risk factors for incident neck and shoulder pain in hospital nurses显示文摘 | Smedley J Inskip H Trevelyan F | 2003 | Occup Environ Med2003，60，11： | 1 |
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