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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes显示文摘 | Tan, KCB Chow, WS Tso, AWK Xu, A Tse, HF Hoo, RLC Betteridge, DJ Lam, KSL | 2007 | 中国生物学文摘2007，21，11： | 7 |
| 3 | Atrial fibrillation显示文摘 | Gregory YH Lip Hung Fat Tse Deirdre A Lane | 2012 | The Lancet . 2012 (9816)2012，，： | 2 |
| 4 | DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas显示文摘 | Bellail A Tse MC Song JH | 2010 | J Cell Mol Med2010，14，6： | 1 |
| 5 | Intensity modulated radiotherapy for sinonasal malignancies with a focus on optic pathway preservation 显示文摘 | Chi A Nguyen 'NP Tse W | 2013 | J Hematol Oncol2013，6，： | 1 |
| 6 | Taurine inhibits rat substan- tia nigra pars reticulata neurons by activation of GABA - and glycine-linked chloride conductance显示文摘 | Ye G Tse A C Yung W | 1997 | Brain Res1997，749，1： | 1 |
| 7 | Economic perspectives of aerodynamic treatments of square tall buildings显示文摘 | Tse K T Hitchcock P A Kwok K C S | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，910： | 1 |
| 8 | Faulty bearing signal recovery from large noise using a hybrid method based on spectral kurtosis and ensemble empirical mode de- composition显示文摘 | Guo W Tse P W Djordjevich A | 2012 | Measurement2012，45，5： | 1 |
| 9 | A multivariate generalized autoregressive conditional hereroskedasticity model with time varying correlations 显示文摘 | Tse Y K and Tsui A K C | 2002 | Journal of Business and Economics Statistics2002，20，： | 1 |
| 10 | Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis显示文摘 | Song JH Bellail A Tse MC | 2006 | J Neurosci2006，26，12： | 1 |
| 11 | Application of mother wavelet functions for automatic gear and bearing fault diagnosis显示文摘 | Rafiee J Rafiee M A Tse P W | 2010 | Expert Systems with Applications2010，37，6： | 1 |
| 12 | Relationship Marketing Orientation:Scale Development and Cross-cuhural Validation显示文摘 | SIN L Y M TSE A C B YAU O H M | 2005 | Journal of Business Research2005，58，2： | 1 |
| 13 | Development andvalidation of a core endurance intervention program: implicationsfor performance in college-age rowers显示文摘 | Tse M McManus A Masters R | 2005 | JStrength Cond Res2005，19，3： | 1 |
| 14 | Faulty bearing signal recovery from large noise using a hybrid method based on spectral kurtosis and ensemble empirical mode decomposition显示文摘 | Guo W Tse P W Djordjevich A | 2012 | Measurement2012，45，： | 1 |
| 15 | The utilizations of building information models in nD modeling: a study of data interfacing and adoption barriers显示文摘 | Tse T K Wong K A Wong K F | 2005 | Journal of Information Technology in Construction2005，，10： | 1 |
| 16 | A phase Ⅰ dose-escalation study of irinotecan in combination with 17 allylamino-17-clemethoxygeldanamycin in patients with solid tumors显示文摘 | Tse A N Klimstra D S Gonen M | 2008 | Clin Cancer Res2008，14，20： | 1 |
| 17 | Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma显示文摘 | Chan H L Hui A Y Wong M L Tse A M Hung L C Wong V W | 2004 | Gut2004，53，： | 1 |
| 18 | Long-term follow-up of early treatment with reverse headgear显示文摘 | Hagg U Tse A Bendens M | 2003 | Eur J Orthod2003，25，： | 1 |
| 19 | Breaking bad news:a Chinese perspective显示文摘 | Tse CY Chong A Fok SY | 2003 | Palliative Medicine2003，17，4： | 1 |
| 20 | A novel technique for selecting mother wavelet function using an intelligent fault diagnosis system 显示文摘 | Rafiee J Tse P W Harifi A | 2009 | Expert Systems with Applications2009，36，3： | 1 |
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