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| 1 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 2 | Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus. | Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson | 2015 | World Journal of Diabetes2015，6，7： | 10 |
| 3 | The control of chondrogenesis显示文摘 | Goldring Mb Tsuchimochi Kljiri k | | 0，，1： | 1 |
| 4 | Successful treatment of pituitary abscess with oral administration of sparfloxacin 显示文摘 | Uchida Y Tsuchimochi N Oku M | 2008 | Intern Med2008，47，12： | 1 |
| 5 | The control of chondrogene- sis 显示文摘 | Goldring MB Tsuchimochi K Ijiri K | 2006 | J Cell Biochem2006，97，1： | 1 |
| 6 | Altered sarcoplasmic reticulum function in rat diaphragm after high-intensity exercise显示文摘 | Matsunaga S Inashima S Tsuchimochi H | 2002 | Acta Physiol Scand2002，176，3： | 1 |
| 7 | Clinical analysis of the patients with hemodialysis associated with intracerebral hematoma显示文摘 | Ikeda K Tsuchimochi H Takeno Y | 2004 | No Shinkei Geka2004，32，12： | 1 |
| 8 | Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node:an animal study显示文摘 | Tsuchimochi M Hayama K Toyama M | | 0，，01： | 1 |
| 9 | Quantification of disc displacement in internal derangement of the temporomandibular joint using magnetic resonance imaging 显示文摘 | Arayasantiparb R Tsuchimochi M | 2010 | Odontology2010，98，1： | 1 |
| 10 | Antimicrobial susceptibility and molecular epidemiological analysis of clinical strains of Pseudomonas aemginosa 显示文摘 | Tsuchimochi N Takuma T Shimono N | 2008 | J Infect Chemother2008，14，： | 1 |
| 11 | An experimental study of new diagnostic methods for the examination of osseous lesions in the temporomandibular joint显示文摘 | EngelkeW Ruttimann U E Tsuchimochi M | 1992 | Oral Surg Oral Med Oral Pathol1992，73，： | 1 |
| 12 | The control of chondrogene- sis显示文摘 | Goldring Mb Tsuchimochi K Ijiri K | 2006 | J Cell Biochem2006，97，1： | 1 |
| 13 | Hyperoxic condition promotes an inflammatory response during cardiopulmonary bypass in a rat model显示文摘 | Fujii Y Shirai M Tsuchimochi H | 2013 | Artif Organs2013，37，12： | 1 |
| 14 | Three basic patterns of changes in serum thyroid hormone levels in Graves' disease during the one-year period after radioiodine ther- apy 显示文摘 | Masayuki Nakajo Shinsaku Tsuchimochi Hiroaki Tanbe | 2005 | Annnals Nuclear Med2005，19，4： | 1 |
| 15 | Altered sarcoplas micreticulum function in rat diaphragm after high intensity exercise显示文摘 | Matsunaga S Inashima S Tsuchimochi H | 2002 | Acta Physiol Scand2002，176，3： | 1 |
| 16 | Hyperoxic condition pro- motes an inflammatory response during cardiopulmonary bypass in a rat model 显示文摘 | Fujii Y Shirai M Tsuchimochi H | 2013 | Artif Organs2013，37，12： | 1 |
| 17 | The control of chondrogenesis显示文摘 | Goldring M B Tsuchimochi K Ijiri K | 2006 | J Cell Biochem2006，97，1： | 1 |
| 18 | An outbreak of Pseu- domonas aeruginosa infections following thoracic surgeries occur- ring via the contamination of bronchoscopes and an automatic endo- scope reprocessor显示文摘 | Shimono N Takuma T Tsuchimochi N | 2008 | J Infect Chemother2008，14，6： | 1 |
| 19 | The control of chondrogenesis显示文摘 | Goldring M B Tsuchimochi K Ijiri K | 2006 | J Cell Biochem2006，97，1： | 1 |
| 20 | The control of chondrogenesis显示文摘 | Goldring MB Tsuchimochi K Ijiri K | 2006 | J Cell Biochem2006，97，1： | 1 |
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