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| 1 | Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow cytometry.RESULTS As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG1 phase and arrest of proliferation at S phase.CONCLUSION As2O3 and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As2O3 and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied. | Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH | 2000 | World Journal of Gastroenterology2000，6，4： | 43 |
| 2 | Bt水稻对飞虱和叶蝉及其卵寄生蜂扩散规律的影响显示文摘研究了Bt水稻两个纯合品系TT9-3和TT9-4在田间对飞虱、叶蝉及其卵寄生蜂扩散规律的影响。结果表明:在Bt稻区与对照(IR72)区间相互扩散的飞虱有白背飞虱(Sogatellafurcifea)、褐飞虱(Nilaparvatalugens);叶蝉有黑尾叶蝉(Nephotetixcincticeps)、白翅叶蝉(Erythroneurasubrufa)和电光叶蝉(Deltpcephalusdorsalis);其中以白背飞虱和黑尾叶蝉为主。扩散数量叶蝉多于飞虱;扩散方向以Bt稻区向对照区扩散为主,其中TT9-3与IR72、TT9-4与IR72间白背飞虱与黑尾叶蝉的扩散量差异均达显著水平(P<0.05)。在Bt稻区与对照区间相互扩散的飞虱和叶蝉的卵寄生蜂有稻虱缨小蜂(Anagrusspp.)和叶蝉柄翅小蜂(Lynaenonlongicrus),数量上后者多于前者,扩散方向也以Bt稻区向对照区扩散为主。 | 陈茂 叶恭银 胡萃 Tu J Datta S K | 2003 | 浙江大学学报(农业与生命科学版)2003，29，1： | 30 |
| 3 | 关键基础设施及其安全管理显示文摘关键基础设施(CI)系统是复杂的、高度相互依存的、网络化的社会—技术系统,一旦系统被中断或者被破坏,将会对国民健康、国土安全、经济稳定以及政府的正常运转等产生重大的影响.主要研究关键基础设施及其安全管理过程中的若干问题,对CI的特点进行了分析和总结,建立了网络化CI系统的体系结构,并利用视图模型来描述系统,同时还给出了灾难处理的一般过程.最后,进一步探讨了如何使用系统工程的方法来分析和模拟网络化CI系统的运行方式、潜在的薄弱环节以及改进这些薄弱环节的实施方法. | 刘晓 张隆飙 Zhang W J Tu Y L | 2009 | 管理科学学报2009，12，6： | 22 |
| 4 | Comeld^TM Joints: A Novel Technique for Bonding Composites and Metal显示文摘Current and future structural applications for composite laminates frequently involve design solutions combining composite laminates and metal; the materials must be joined. Two conventional means of joining are available mechanical joining and adhesive bonding. Both methods have critical disadvantages. A novel surface treatment for metals developed at TWI, Surfi-Sculpt, leads to the formation of surface protrusions on metal surfaces. These protrusions are typically 1.0 mm high and 0.6 mm in diameter. The surface modified metal can be bonded with composite laminates to form a Comeld~TM joint. These joints can be described as a combination of mechanical fastening and adhesive bonding. This paper describes our current work using finite element modelling to optimize the protrusions in respect to their geometry and distribution. The simulations require multi-scale modelling techniques to transfer results between the global model of the whole joint and the unit cell models containing a protrusion. Results from the simulations show critical effects on stress distributions arising from changing protrusion geometry. These joints show significant advantages over conventional adhesive joining technologies and their application would allow improved performance for combinations of metal and composite laminates. | Tu W Guild F J Hogg P J | 2009 | 稀有金属材料与工程2009，38，A03： | 14 |
| 5 | 强化针刺对膝关节骨性关节炎的疗效显示文摘膝关节骨关节炎(KOA)患者的治疗选择有限。虽然已经发表的几项研究证明了针灸对KOA症状的疗效,但对电针的效果知之甚少。本研究评估了电针(EA)治疗KOA的效果。这项多中心、随机对照试验招募了年龄在45-75岁之间,且经影像学证实的KOA至少持续6个月的患者。受试者被随机分为三组,均进行每周3次,每次30分钟,持续8周的治疗。这些组包括假针灸(SA)组、不接受电流的手动针灸(MA)组和接受2/100 Hz电流治疗的电针(EA)组。主要结果衡量指标是“反应率”,是指受试者在第8周时疼痛和功能获得最小临床重要改善的比例。功能评定采用西安大略和麦克马斯特大学骨关节炎指数功能量表,疼痛评定采用数值评分量表(NRS)。收集了442例患者的数据。在第8周,EA组的反应率为60.3%,MA组为58.6%,SA组为47.3%,(EA vs SA;P=0.0507,MA vs SA P=0.023)。EA组和MA组在16周和26周时的反应率均显著高于SA组。结论:本项对膝关节骨性关节炎患者的研究发现,针灸可有效减轻疼痛,改善功能,并且电针可更快地发挥作用。 | 张东云(译) Tu J | 2021 | 中国康复2021，36，9： | 8 |
| 6 | 基于自动测量的诊室血压高血压诊断标准与心血管病风险显示文摘与血压相关的心血管事件风险很大程度是基于台式水银血压计的人群测量数据。考虑到电子血压计逐步替代台式水银血压计,该研究采用全自动血压计在研究对象独自安静休息时多次读取数据,以探讨导致心血管风险显著增加的血压水平。方法:纳入〉65岁的未经治疗的高血压社区居民3627例。从社区药店和家庭医生获得受试者未受干扰时的坐位自动诊室血压数据。针对致命性及非致命性心血管事件,受试者随访(4.9±1.0)年。 | Myers MG Kaczorowski J Paterson JM Dolovich L Tu K 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 7 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 8 | Thermal-hydrodynamic modelling of bubbly flows with heat and mass transfer 显示文摘 | Yeoh G H Tu J Y | 2005 | AIChE Journal2005，51，： | 1 |
| 9 | Phycobilin : cystein-84 biliprotein lyase,a near universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins 显示文摘 | Zhao K H Su P Tu J M | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 10 | Numerical modelling and validation of gas-particle flow in an in-line tube bank显示文摘 | Tian Z F Tu J Y Yeoh G H | 2007 | Computers & Chemical Engineering2007，31，9： | 1 |
| 11 | Modeling and algorithm on a class of mechanical systems with unilateral constraints显示文摘 | Feng Q Tu J | 2006 | Archive of Applied Mechanics2006，76，12： | 1 |
| 12 | Enhanced low voltage cycling stability of LiMn204 cathode by ZnO coating for lithium ion batteries 显示文摘 | Tu J Zhao X B Xie J Cao G S Zhuang D G Zhu T J Tu J P | 2007 | Journal of Alloys and Compounds2007，432，12： | 1 |
| 13 | A new study on reliability-based design optimization显示文摘 | TU J CHOI K K PARK Y H | 1999 | Journal of Mechanical Design1999，121，： | 1 |
| 14 | Oxidative protein folding in eukaryotes:mechanisms and consequences显示文摘 | Tu B P Weissman J S | 2004 | J Cell Biol2004，164，： | 1 |
| 15 | Thermoelasfic Instability Monitoring for Preventing Spindle Bearing Seizure 显示文摘 | Tu J F | 1995 | Tribology Transactions1995，38，1： | 1 |
| 16 | Persistent toxic substances in remote lake and coastal sediments from Svalbard, Norwegian Arctic: levels, sources and fluxes 显示文摘 | Liping Jiao Gene J Zheng Tu Binh Minh | 2009 | Environmental Pollution2009，157，： | 1 |
| 17 | Induction of innate lymphoid cell-de- rived interleukin-22 by the transcription factor STAT3 mediates pro- tection against intestinal infection 显示文摘 | Guo XH Qiu J Tu T | 2014 | Immunity2014，40，1： | 1 |
| 18 | Treatment of distal femoral fracture by minimally invasive percutaneous plate osteosynthesis:comparison between the dynamic condylar screw and the less invasive stabilization system显示文摘 | Kao F C Tu Y K Su J Y | | 0，，07： | 1 |
| 19 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 20 | State and input estimation for a class of uncertain systems 显示文摘 | CORLESS M TU J | 1998 | Automatica1998，34，6： | 1 |
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