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| 1 | Parameter Optimization of Interval Type-2 Fuzzy Neural Networks Based on PSO and BBBC Methods显示文摘Interval type-2 fuzzy neural networks(IT2FNNs)can be seen as the hybridization of interval type-2 fuzzy systems(IT2FSs) and neural networks(NNs). Thus, they naturally inherit the merits of both IT2 FSs and NNs. Although IT2 FNNs have more advantages in processing uncertain, incomplete, or imprecise information compared to their type-1 counterparts, a large number of parameters need to be tuned in the IT2 FNNs,which increases the difficulties of their design. In this paper,big bang-big crunch(BBBC) optimization and particle swarm optimization(PSO) are applied in the parameter optimization for Takagi-Sugeno-Kang(TSK) type IT2 FNNs. The employment of the BBBC and PSO strategies can eliminate the need of backpropagation computation. The computing problem is converted to a simple feed-forward IT2 FNNs learning. The adoption of the BBBC or the PSO will not only simplify the design of the IT2 FNNs, but will also increase identification accuracy when compared with present methods. The proposed optimization based strategies are tested with three types of interval type-2 fuzzy membership functions(IT2FMFs) and deployed on three typical identification models. Simulation results certify the effectiveness of the proposed parameter optimization methods for the IT2 FNNs. | Jiajun Wang Tufan Kumbasar | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 14 |
| 2 | Accurate positioning of the 24-hour pH monitoring catheter:Agreement between manometry and pH step-up method in two patient positions显示文摘瞄准:在二个不同耐心的位置调查在食道的测压法和 pH 加速方法之间的协议。方法:十八个题目在学习被包括。首先,到更低的食道的括约肌(LES ) 的近似边阶的从鼻子的距离被测量压力计的联盟者。然后一个不同调查者,被使看不见第一研究的结果,用 pH 加速方法测量了一样的距离,与病人在一起正直并且背卧位。对在二种技术之间的同意的一个评价被执行。结果:在背卧位,仅仅一个题目的测量在为正确的放接受的范围(对 LES 3 厘米远侧或近似的 <=) 外面。在正直的位置,在测量的错误在五个题目被认出。Bland-Altman 阴谋表明在大小之间的好同意获得了压力计的联盟者并且由在与在背卧位的病人一起的方法上面的 pH 步。结论:在情况中非压力计的察觉设备的可获得性, pH 加速方法能便于放在背卧位与病人一起监视导管的 24 h pH。如果我们的结果被进一步的研究支持,这应该与怀疑的胃的食道的倒流疾病为题目在临床的实践增加 pH-metry 的使用。 | Mehmet Fatih Can Gokhan Yagci Sadettin Cetiner Mustafa Gulsen Taner Yigit Erkan Ozturk Semih Gorgulu Turgut Tufan | 2007 | World Journal of Gastroenterology2007，13，46： | 6 |
| 3 | Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention显示文摘OBJECTIVE:Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events。 We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients >65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction。 METHODS:We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 ±5.4)。 Patients were divided into two groups according to admission blood glucose levels。 Group : low glucose group (LLG), glucose < 168 mg/dL; and Group 2: high glucose group (HGG), glucose >168 mg/dL。 RESULTS:In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P <0.001)。 Multivariate regression analysis showed: Killip > 1, post-thrombolysis in MI <3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P <0.001)。 CONCLUSIONS:Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality。 | Ahmet Ekmekci Mahmut Uluganyan Fatif Tufan Huseyin Uyarel Gurkan Karaca Seref Kul Barl(s) Gungor | 2013 | Journal of Geriatric Cardiology2013，10，4： | 6 |
| 4 | The predictive value of triglyceride-glucose index for in-hospital and one-year mortality in elderly non-diabetic patients with ST-segment elevation myocardial infarction显示文摘BACKGROUND Triglyceride-glucose(TyG)index,a reliable marker of insulin resistance,was associated with cardiovascular morbidity and mortality.This study aimed to evaluate the predictive value of TyG index for mortality in elderly non-diabetic pa-tients with ST-segment elevation myocardial infarction(STEMI).METHODS In total,430 non-diabetic patients aged over 65 years with STEMI were consecutively included.The TyG index was calculated by using the following formula:TyG index=ln(fasting triglyceride×fasting glucose/2).The 5-item modified frailty index score was utilized to determine comorbidities.Patients were divided into three groups based on TyG index tertiles.RESULTS Patients included into high TyG index tertile were male and had higher body mass index,glucose,triglyceride,low-density lipoprotein cholesterol,5-item modified frailty index and GRACE risk score;and had low systolic blood pressure,estim-ated glomerular filtration rate and left ventricular ejection fraction.A one-unit increase in TyG index was associated with 3.03 ex-tra cases per 1000 person-day for in-hospital mortality and 0.29 extra cases per 1000 person-day for long-term mortality.There was a non-linear relationship between TyG index and the risk of mortality with an increased risk above 8.5 for TyG index.Kaplan-Meier survival curves revealed that patients in high TyG index tertile had higher in-hospital and long-term mortality rates than those in low TyG index tertile.CONCLUSIONS This was the first study to demonstrate that the TyG index could predict in-hospital and long-term mortality in elderly non-diabetic STEMI patients. | FaysalŞaylık TufanÇınar Murat Selçuk İbrahim Halil Tanboğa | 2022 | Journal of Geriatric Cardiology2022，19，8： | 3 |
| 5 | Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma显示文摘AIM:To assess the validity of the Milan and University of California San Francisco(UCSF) criteria and examine the long-term outcome of orthotopic liver transplantation(OLT) in patients with hepatocellular carcinoma(HCC) in a single-center study.METHODS:This study is a retrospective review of prospectively collected data.Between 1998 and 2009,56 of 356 OLTs were performed in patients with HCC.Based on pathological examination of liver explants,patients were retrospectively categorized into 3 groups:Milan +(n = 34),Milan-/UCSF +(n = 7) and UCSF-(n = 14).RESULTS:Median follow-up period was 39.5(1-124) mo.The 5-year overall survival rates in the Milan +,Milan-/UCSF + and UCSF-groups were 87.7%,53.6% and 33.3%,respectively(P < 0.000).Within these groups,tumor recurrence was determined in 5.8%,14.3% and 40% of patients,respectively(P < 0.011).Additionally,the presence of microvascular invasion within the explanted liver had a negative effect on the 5-year disease free survival(74.7% vs 46.7%,P < 0.044).CONCLUSION:The Milan criteria are reliable in the selection of suitable candidates for OLT for the treatment of HCC.For cases of OLT involving living donors,the UCSF criteria may be applied. | Tarkan Unek Sedat Karademir Naciye Cigdem Arslan Tufan Egeli Gulsen Atasoy Ozgul Sagol Funda Obuz Ibrahim Astarcioglu | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 6 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 7 | Mean plateletvolume (MPV) as an inflammatory marker in ankylosingspondylitis and rheumatoid arthritis 显示文摘 | Kisacik B Tufan A Kalyoncu U | 2008 | Joint BoneSpine2008，75，3： | 1 |
| 8 | Nonconvulsive stalus epilepticus due to ifosfamide 显示文摘 | Kilickap S Cakar Monal IK Tufan A | 2006 | Ann Phannacother2006，40，2： | 1 |
| 9 | Factors impacting the innovative capacity in large-scale eompanies显示文摘 | KOC TUFAN CEMIL CEYLAN | 2007 | Technova- tion2007，，27： | 1 |
| 10 | Uncomplicat- ed diabetes does not accelerate age-related sarcopenia 显示文摘 | Akpinar TS Tayfur M Tufan F | 2014 | Aging Male2014，，： | 1 |
| 11 | Atrial electromechanical delay and diastolic dysfunction in primary Sjga'en syndrome 显示文摘 | Akyel A Tavil Y Tufan A | 2012 | Clin Invest Med2012，35，5： | 1 |
| 12 | Automatic detection of bubbles in the subclavian vein using Doppler ultrasound signals显示文摘 | TUFAN K ADEMOGLU A KURTARAN E | 2006 | Aviat Space Environ Med2006，77，9： | 1 |
| 13 | Safety of high-dose intravenous immunoglobulin in systemic autoimmune diseases显示文摘 | Fatih Tufan Sevil Kamali Burak Erer Ahmet Gul Murat Inanc Lale Ocal Meral Konice Orhan Aral | 2007 | Clinical Rheumatology2007，，11： | 1 |
| 14 | Neutrophil- to- lymphocyte ratio, insulin resistance, and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease 显示文摘 | TURKMEN K TUFAN F SELUK E | 2013 | Indian J Nephrol2013，23，1： | 1 |
| 15 | A very unusual cause of chronic abdominal pain caused by a giant bladder stone formed on a foley catheter left in bladder显示文摘 | Cern OY Tufan S Abidin T | 2001 | Int Urology and Nep2001，33，： | 1 |
| 16 | Serum or plasma cartilage oligomeric matrix protein concentration as a diagnostic marker in pseudoachondroplasia:differential diag- nosis of a family 显示文摘 | Tufan AC Satiroglu-Tufan NL Jackson GC | 2007 | Eur J Hum Genet2007，15，10： | 1 |
| 17 | Diagnosis, management, and results of treatment for aortopulmo- narywindow显示文摘 | MURAT M TUFAN P ATIF A | 2004 | Cardiol Young2004，14，： | 1 |
| 18 | Assessment of reproductive ageing patterns by hormonal and ultrasonographic ovarian reserve tests显示文摘 | Tufan E Elter K Durmusoglu F | 2004 | Hum Rep Rod2004，19，11： | 1 |
| 19 | The association between neutro-phil/lymphocyte ratio and disease activity in rheumatoid arthritis andankylosing spondylitis 显示文摘 | Mercan R Bitik B Tufan A | 2015 | J Clin Lab Anal2015，36，3： | 1 |
| 20 | The chick embryo chorioallantoic membrane as a model system for the study of tumor angiogenesis,invasion and development of anti-angiogenic agents显示文摘 | Tufan AC Satiroglu-Tufan NL | 2005 | Curr Cancer Drug Targets2005，5，4： | 1 |
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