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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Treatment strategies for mass burn casualties显示文摘因为很多严重受伤的病人在一短时间以内被送,背景集体灼伤伤亡总是是对一个医疗队的大挑战。通常,高死亡正在逼近。从牺牲品的成功的治疗获得的经验可能在在武装 conflict.Methods 指导集体伤亡的照顾是有用的在单个批的 35 个灼伤牺牲品,坐飞机不停地被转移并且从一个远省的高速公路,被承认 48 个小时损害以后。所有病人与吝啬的年龄是男性的(22.4 ? 蟠 ?( | CHAI Jia-ke SHENG Zhi-yong YANG Hong-ming HAO Dai-feng SHEN Chuan-an JIA Xiao-ming LI Feng JING Sa LI Li-gen SONG Hui-feng JIA Chi-yu TUO Xiao-ye SUN Tian-jun HU Quan | 2009 | Chinese Medical Journal2009，，5： | 10 |
| 3 | Whole-exome sequencing identifies novel mutations in genes responsible for retinitis pigmentosa in 2 nonconsanguineous Chinese families显示文摘AIM: To detect the pathogenetic mutations responsible for nonsyndromic autosomal recessive retinitis pigmentosa(RP) in 2 nonconsanguineous Chinese families. METHODS: The clinical data, including detailed medical history, best corrected visual acuity(BCVA), slit-lamp biomicroscope examination, fundus photography, optical coherence tomography, static perimetry, and full field electroretinogram, were collected from the members of 2 nonconsanguineous Chinese families preliminarily diagnosed with RP. Genomic DNA was extracted from the probands and other available family members;wholeexome sequencing was conducted with the DNA samples provided by the probands, and all mutations detected by whole-exome sequencing were verified using Sanger sequencing in the probands and the other available family members. The verified novel mutations were further sequenced in 192 ethnicity matched healthy controls.RESULTS: The patients from the 2 families exhibited the typical symptoms of RP, including night blindness and progressive constriction of the visual field, and the fundus examinations showed attenuated retinal arterioles, peripheral bone spicule pigment deposits, and waxy optic discs. Whole-exome sequencing revealed a novel nonsense mutation in FAM161 A(c.943 A>T, p.Lys315*) and compound heterozygous mutations in RP1 L1(c.56 C>A, p.Pro19 His;c.5470 C>T, p.Gln1824*). The nonsense c.5470 C>T, p.Gln1824* mutation was novel. All mutations were verified by Sanger sequencing. The mutation p.Lys315* in FAM161A co-segregated with the phenotype, and all the nonsense mutations were absent from the ethnicity matched healthy controls and all available databases.CONCLUSION: We identify 2 novel mutations in genes responsible for autosomal recessive RP, and the mutation in FAM161A is reported for the first time in a Chinese population. Our result not only enriches the knowledge of the mutation frequency and spectrum in the genes responsible for nonsyndromic RP but also provides a new target for future gene therapy. | Yan-Shan Hu Hui Song Yin Li Zi-Yun Xiao Tuo Li | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 6 |
| 4 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 5 | Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine显示文摘Objective: The aim of the present study was to investigate the effects of 5-fluorouracil(5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells(DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide(α-GC) tumor vaccine exhibits synergistic effects on the treatment of colon cancer in mice.Methods: The combination of the Toll like receptor(TLR) ligands and/or 5-Fu/oxaliplatin was added into myeloid-derived DCs in vitro culture. DC phenotypic changes were detected by flow cytometry, and the secretion of DC cytokines was detected by cytometric bead array(CBA). A MC38 mouse colon cancer model was constructed and the DCs were isolated from the spleen, tumor tissue and lymph nodes following intraperitoneal injection of 5-Fu/oxaliplatin. The cell phenotypes were detected by flow cytometry. The tumor infiltrating leukocytes,splenocytes and lymph node cells were co-cultured with the dead MC38 tumor cells, and the secretion levels of interferon-γ(IFN-γ) were detected. 5-Fu/oxaliplatin combined with our previously developed CD1d-MC38/α-GC tumor vaccine was used to inhibit the growth of MC38 colon cancer in mice, and the tumor growth rate and survival time were recorded.Results: 5-Fu/oxaliplatin exerted no significant effect on the expression of the stimulating phenotypes of DCs in vitro, while it could reduce the expression of programmed death ligand 1/2(PD-L1/L2) and promote interleukin-12(IL-12) secretion by DCs. Furthermore 5-Fu/oxaliplatin was beneficial to the differentiation of T-helper 1(Th1) cells. 5-Fu/oxaliplatin further enhanced the stimulating phenotypic expression of DCs in tumor bearing mice, decreased PD-L1/L2 expression, and specifically activated the lymphocytes. The CD1d-MC38/α-GC tumor vaccine combined with 5-Fu/oxaliplatin could exert a synergistic role that resulted in a significant delay of the tumor growth rate, and an increase in the survival time of tumor bearing mice.Conclusions: 5-Fu/oxaliplatin decreased the expression of the DC inhibitory phenotypes PD-L1/L2, promoted DC phenotypic maturation in tumor bearing mice, activated the lymphocytes of tumor bearing mice, and exerted synergistic effects with the CD1d-MC38/α-GC colon cancer tumor vaccine. | Xinqiang Hong Tiangeng Dong Tuo Yi Jianwei Hu Zhen Zhang Shengli Lin Weixin Niu | 2018 | Chinese Journal of Cancer Research2018，30，2： | 4 |
| 6 | Efficient scheme of low-dose CT reconstruction using TV minimization with an adaptive stopping strategy and sparse dictionary learning for post-processing显示文摘随着CT(computed tomography)中过量辐射剂量带来的健康风险日渐引发人们的担忧,低剂量CT得到了大量的关注。然而对于低剂量CT成像而言,在降低剂量的同时保证图像的高质量是一个很大的挑战。相比传统的滤波反投影算法,基于压缩感知的迭代重建法取得了良好的成像效果。但是迭代重建计算复杂度高,阻碍了其临床应用。本文提出一种结合全变分(total variation,TV)最小化和稀疏字典学习的重建方法,不仅提高了重建效果,而且通过自适应的停止策略提高了重建速度。实验结果表明,本文提出的方法相比其他类型的方法能获得更好的图像质量和更高的计算效率。 | Yong DING Tuo HU | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，12： | 2 |
| 7 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 8 | 男性直肠癌患者全直肠系膜切除术后吻合口漏风险增高显示文摘背景:患者性别对于直肠癌全直肠系膜切除术(TME)后吻合口漏形成的影响目前仍存在争议。本研究旨在评估性别与吻合口漏的相关性。方法:回顾性分析2010-2014年间在我院接受TME手术且行一期吻合的直肠癌患者的临床资料。比较男性与女性患者术后吻合口漏发生率。结果:入组的956例直肠癌患者中,男性587例(61.4%),女性369例(38.6%)。相较于女性患者,男性患者中吸烟和饮酒的比例更高,但有腹部手术史者较少;术前肠梗阻的比例更高,肿瘤本身也相对较大。全组病例中出现术后吻合口漏81例(8.5%),其中男性患者发生率高于女性患者(10.6%vs.5.1%,P¼0.003)。多因素逻辑回归分析证实,男性是术后吻合口漏发生的独立危险因素(OR¼2.41,95%CI:1.37-4.23,P¼0.002);对于腹腔镜TME手术的亚组分析也得到了相同的结果(OR¼2.11,95%CI:1.15-3.89,P¼0.016)。结论:男性直肠癌患者TME手术后吻合口漏的发生风险相对较高。保护性肠造口或可为吻合口提供保护,降低吻合口漏的发生风险,尤其是对于男性患者。 | Jian-ping Wang and Ping Lan Chi Zhou Xian-rui Wu Xuan-hui Liu Yu-feng Chen Jia Ke Xiao-wen He Xiao-sheng He Tuo Hu Yi-feng Zou Xiao-bin Zheng Hua-shan Liu Jian-cong Hu Xiao-jian Wu Jian-ping Wang Ping Lan | 2018 | Gastroenterology Report2018，6，2： | 2 |
| 9 | Elevated preoperative CA125 is associated with poor survival in patients with metastatic colorectal cancer undergoing primary tumor resection:a retrospective cohort study显示文摘Background The impact of the preoperative carbohydrate antigen 125(CA125)level on the survival of metastatic colorectal cancer(CRC)patients undergoing primary tumor resection(PTR)remains uncertain.The aim of this study was to assess the prognostic value in overall survival(OS)and cancer-specific survival(CSS)between patients with and without an elevated preoperative CA125 level.Methods All metastatic CRC patients receiving PTR between 2007 and 2017 at the Sixth Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)were retrospectively included.OS and CSS rates were compared between patients with and without elevated preoperative CA125 levels.Results Among 326 patients examined,46(14.1%)exhibited elevated preoperative CA125 levels and the remaining 280(85.9%)had normal preoperative CA125 levels.Patients with elevated preoperative CA125 levels had lower body mass index,lower preoperative albumin level,lower proportion of preoperative chemotherapy,higher carcinoembryonic antigen and carbohydrate antigen 19–9(CA19–9)levels,poorer differentiation,and more malignant histopathological type than patients with normal preoperative CA125 levels.In addition,patients with elevated preoperative CA125 levels exhibited more advanced pathological T and N stages,more peritoneal metastasis,and more vessel invasion than patients with normal preoperative CA125 levels.Moreover,the primary tumor was more likely to be located at the colon rather than at the rectum in patients with elevated CA125 levels.Both OS and CSS rates in patients with elevated preoperative CA125 levels were significantly lower than those in patients with normal preoperative CA125 levels.Multivariate Cox regression analysis revealed that an elevated preoperative CA125 level was significantly associated with poor prognosis in metastatic CRC patients undergoing PTR.The hazard ratio(HR)in OS was 2.36(95%confidence interval[CI],1.67–3.33,P<0.001)and the HR in CSS was 2.50(95%CI,1.77–3.55,P<0.001).The survival analysis stratified by peritoneal metastasis also demonstrated that patients with elevated preoperative CA125 levels had lower OS and CSS rates regardless of peritoneal metastasis.Conclusion Based on an analysis of metastatic CRC patients undergoing PTR,an elevated preoperative CA125 level was associated with poor prognosis,which should be taken into consideration in clinical practice. | Jun-Hua Huang Hua-Shan Liu Tuo Hu Zong-Jin Zhang Xiao-Wen He Tai-Wei Mo Xiao-Feng Wen Ping Lan Lei Lian Xian-Rui Wu | 2022 | Gastroenterology Report2022，10，1： | 2 |
| 10 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 11 | 过表达CXCR4的骨髓间充质干细胞通过增强的肠道归巢能力抑制小鼠肠炎相关肿瘤的形成显示文摘背景:骨髓来源间充质干细胞(MSC)用于炎症性肠病(IBD)及IBD相关肠癌的治疗潜力已受到越来越多的关注。然而,MSC究竟是抵制还是促进肿瘤形成仍然存在争议。基质细胞衍生因子1(SDF-1)/C-X-C趋化因子受体4(CXCR4)在MSC归巢过程具有非常关键的作用。本研究旨在评估过表达CXCR4的MSC在IBD瘤变过程中的作用。方法:应用携带CXCR4或绿色荧光蛋白(GFP)的慢病毒载体转染MSC。通过细胞趋化实验和侵袭实验检测CXCR4表达情况。采用偶氮甲烷和葡聚糖硫酸钠(DSS)制作小鼠结肠炎成瘤模型。将实验小鼠分为3组,分别注射磷酸盐缓冲液(PBS)、MSC-GFP或MSC-CXCR4。结果:与MSC-GFP组小鼠相比,MSC-CXCR4小鼠体重下降程度减少,结肠相对更长,肿瘤数量更少,肿瘤负荷减轻;此外,结肠组织中促炎细胞因子表达和STAT3磷酸化水平均下调。结论:过表达CXCR4的MSC表现出抑瘤功能,其机制可能是CXCR4促进MSC向炎性肠组织的归巢。 | Xiao-Bin Zheng Xiao-Wen He Long-Juan Zhang Hua-Bo Qin Xu-Tao Lin Xuan-Hui Liu Chi Zhou Hua-Shan Liu Tuo Hu Hai-Chun Cheng Xiao-Sheng He Xian-Rui Wu Yu-Feng Chen Jia Ke Xiao-Jian Wu Ping Lan | 2019 | Gastroenterology Report2019，7，2： | 2 |
| 12 | TMEM16F may be a new therapeutic target for Alzheimer's disease显示文摘TMEM16F is involved in many physiological processes such as blood coagulation,cell membrane fusion and bone mineralization.Activation of TMEM16F has been studied in various central nervous system diseases.High TMEM16F level has been also found to participate in microglial phagocytosis and transformation.Microglia-mediated neuroinflammation is a key factor in promoting the progression of Alzheimer’s disease.However,few studies have examined the effects of TMEM16F on neuroinflammation in Alzheimer’s disease.In this study,we established TMEM16F-knockdown AD model in vitro and in vivo to investigate the underlying regulatory mechanism about TMEM16F-mediated neuroinflammation in AD.We performed a Morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia M1/M2 phenotype and NLRP3 inflammasome.Our results showed that TMEM16F was elevated in 9-month-old APP/PS1 mice.After TMEM16F knockdown in mice,spatial memory ability was improved,microglia polarization to the M2 phenotype was promoted,NLRP3 inflammasome activation was inhibited,cell apoptosis and Aβplaque deposition in brain tissue were reduced,and brain injury was alleviated.We used amyloid-beta(Aβ_(25-35))to stimulate human microglia to construct microglia models of Alzheimer’s disease.The levels of TMEM16F,inducible nitric oxide synthase(iNOS),proinflammatory cytokines and NLRP3 inflammasome-associated biomarkers were higher in Aβ_(25-35) treated group compared with that in the control group.TMEM16F knockdown enhanced the expression of the M2 phenotype biomarkers Arg1 and Socs3,reduced the release of proinflammatory factors interleukin-1,interleukin-6 and tumor necrosis factor-α,and inhibited NLRP3 inflammasome activation through reducing downstream proinflammatory factors interleukin-1βand interleukin-18.This inhibitory effect of TMEM16F knockdown on M1 microglia was partially reversed by the NLRP3 agonist Nigericin.Our findings suggest that TMEM16F participates in neuroinflammation in Alzheimer’s disease through participating in polarization of microglia and activation of the NLRP3 inflammasome.These results indicate that TMEM16F inhibition may be a potential therapeutic approach for Alzheimer’s disease treatment. | Zhi-Qiang Cui Xiao-Ying Hu Tuo Yang Jing-Wei Guan Ying Gu Hui-Yuan Li Hui-Yu Zhang Qing-Huan Xiao Xiao-Hong Sun | 2023 | Neural Regeneration Research2023，18，3： | 2 |
| 13 | Efficient CO_(2) adsorption and mechanism on nitrogen-doped porous carbons显示文摘In this work,nitrogen-doped porous carbons(NACs)were fabricated as an adsorbent by urea modification and KOH activation.The CO_(2) adsorption mechanism for the NACs was then explored.The NACs are found to present a large specific surface area(1920.72-3078.99 m2·g^(-1))and high micropore percentage(61.60%-76.23%).Under a pressure of 1 bar,sample NAC-650-650 shows the highest CO_(2) adsorption capacity up to 5.96 and 3.92 mmol·g^(-1) at 0 and 25℃,respectively.In addition,the CO_(2)/N_(2) selectivity of NAC-650-650 is 79.93,much higher than the value of 49.77 obtained for the nonnitrogen-doped carbon AC-650-650.The CO_(2) adsorption capacity of the NAC-650-650 sample maintains over 97% after ten cycles.Analysis of the results show that the CO_(2) capacity of the NACs has a linear correlation(R^(2)=0.9633)with the cumulative pore volume for a pore size less than 1.02 nm.The presence of nitrogen and oxygen enhances the CO_(2)/N_(2) selectivity,and pyrrole-N and hydroxy groups contribute more to the CO_(2) adsorption.In situ Fourier transform infrared spectra analysis indicates that CO_(2) is adsorbed onto the NACs as a gas.Furthermore,the physical adsorption mechanism is confirmed by adsorption kinetic models and the isosteric heat,and it is found to be controlled by CO_(2) diffusion.The CO_(2) adsorption kinetics for NACs at room temperature and in pure CO_(2) is in accordance with the pseudo-first-order model and Avramís fractional-order kinetic model. | Yanxia Wang Xiude Hu Tuo Guo Jian Hao Chongdian Si Qingjie Guo | 2021 | Frontiers of Chemical Science and Engineering2021，15，3： | 1 |
| 14 | 术前低蛋白血症会增加克罗恩病一期肠吻合术后腹腔内感染性并发症的发生风险显示文摘目的:本研究旨在探讨术前低蛋白血症对克罗恩病(CD)患者一期肠吻合术后发生腹腔内感染性并发症(IASCs)的影响。方法:2007-2015年期间所有行肠切除一期肠吻合手术的CD患者纳入研究。采用单因素和多因素分析评估术前低蛋白血症(白蛋白<30 g/L)与术后IASCs发生风险的关系。结果:共计124例患者纳入研究,其中117例(94.4%)可以获得术前白蛋白水平的数据。13例(11.7%)患者术前合并低蛋白血症。相较之下,术前低蛋白血症患者CD诊断至手术的间期更长(P=0.012),术前服用5氨基水杨酸的比例更高(P=0.013),术中发现小肠梗阻的比例更高(P=0.015)。共有24例(19.4%)患者术后出现IASCs。单因素分析显示,术前低蛋白血症患者术后IASCs风险更高(P=0.012)。多因素分析证实,术前低蛋白血症是术后IASCs的独立危险因素(OR=4.67,95%CI:1.28–17.04,P=0.02)。将术前白蛋白水平作为一个连续型变量进行多因素分析,亦可得到相同的结果(P=0.019)。结论:对于行肠切除一期肠吻合的CD患者,术前低蛋白血症提示术后IASCs发生风险增高。改善术前营养状态或可降低术后IASCs的发生风险。 | Xuanhui Liu Xianrui Wu Chi Zhou Tuo Hu Jia Ke Yufeng Chen Xiaosheng He Xiaobin Zheng Xiaowen He Jiancong Hu Min Zhi Xiang Gao Pinjin Hu Xiaojian Wu Ping Lan | 2017 | Gastroenterology Report2017，5，4： | 1 |
| 15 | Enhanced Mechanical Properties of Poly(arylene sulfide sulfone)Membrane by Co-electrospinning with Poly(m-xylene adipamide)显示文摘The mechanical properties of poly(arylene sulfide sulfone)(PASS) electrospun membrane were significantly enhanced by coelectrospinning with semi-aromatic nylon poly(m-xylene adipamide)(MXD6), another engineering plastic with high thermal stability and good mechanical properties. The tensile strength of PASS membrane increased with increased incorporation of MXD6, and was tripled when 20%MXD6 was incorporated. The mechanism of the mechanical property improvement is the existence of hydrogen bonding interaction between PASS and MXD6 and between adjacent fibers at the intersections. Thermal properties of the PASS/MXD6 membranes were evaluated by differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA), which showed that the membranes could be stably utilized up to180 °C without any change in appearance and without decomposition. Contact angle measurements of all the membranes showed hydrophobic character. To demonstrate the potential applications of PASS/MXD6 blend membranes, their oil absorption capacities were evaluated with three oils of different viscosities, which proved that the PASS/MXD6 membranes are better absorbents than commercial non-woven polypropylene fibers. Therefore, PASS/MXD6 fibrous membranes produced by electrospinning have a great potential in practical applications. | Lu Chen Xin-Lin Tuo Xi-Chuan Fan Chun-Jie Xie Bao-Hua Guo Jian Yu Ping Hu Zhao-Xia Guo | 2020 | Chinese Journal of Polymer Science2020，38，1： | 1 |
| 16 | Comparison of long non?coding RNAs, microRNAs and messenger RNAs involvedin initiation and progression of esophageal squamous cell carcinoma显示文摘 | Su?Qing Li Feng Li Yun Xiao Chun?Mei Wang Lei Tuo Jing Hu Xiao?Bin Yang Jin?Song Wang Wei?Hong Shi Xia Li Xiu?Feng Cao | 2014 | Molecular Medicine Reports2014，，2： | 1 |
| 17 | RNA Interference Targeting Snail Inhibits the Transforming Growth Factor β 2-Induced Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells显示文摘 | Ping Li Jiaona Jing Jianyan Hu Tiejun Li Yuncheng Sun Huaijin Guan Jingsheng Tuo | 2013 | Journal of Ophthalmology2013，，： | 1 |
| 18 | Will lithium-sulfur batteries be the next beyond-lithium ion batteries and even much better?显示文摘Lithium-ion batteries(LIBs)are undoubtedly the current working-horse in almost all portable electronic devices,electric vehicles,and even large-scale stationary energy storage.Given the problems faced by LIBs,a big question arises as to which battery(ies)would be the“Beyond LIBs”batteries.Among the front-runners,lithium-sulfur batteries(LSBs)have been extensively pursued owing to their intrinsically high energy density and extremely low cost.Despite the steady and sometimes exciting progress reported on sulfur chemistry and cell performance at laboratory scales over the past decade,one of the major bottlenecks is the poor cyclability.In this perspective,we examine the key challenges and opportunities faced by LSBs,as well as approaches at the materials,electrode/electrolyte and cell integration levels that can be taken to transform LSBs from a front-runner to a real leading champion in the pursuit of the“Beyond LIBs”.While the key new mechanistic insights are very important,we propose a set of the near-future research directions for both the liquid and solid state LSBs,where the currently on-going parallel pursuits of both liquid and solid LSBs will be converging.The“liquid current”will gradually be taken over by“solid future”in the expected LSBs commercialization in the coming decade. | Jianguo Sun Tuo Wang Yulin Gao Zhenghui Pan Runpeng Hu John Wang | 2022 | InfoMat2022，4，9： | 1 |
| 19 | Investigation of the Thermal Decomposition Behavior of Oleuropein with Many Pharmacological Activities from Olive by Thermogravimetry显示文摘Due to the existence of poly-hydroxyl structures,the temperature may have an effect on the thermal stability of oleuropein for its applications.In the current study,the thermal decomposition process and kinetics behavior of oleuropein from the olive resource were researched by thermogravimetric theoretical analysis methods and non-isothermal kinetics simulation.The results of thermogravimetry analysis showed the whole thermal decomposi-tion process of oleuropein involved two stages,with 21.22%of residue.It was also revealed that high heating rates of more than 20 K min^(-1) led to significant thermal hysteresis and inhibited the whole thermal decomposition behavior of oleuropein.Moreover,an investigation of the thermal decomposition kinetics indicated that the non-isothermal decomposition behavior followed a D3 model during thefirst stage(three-dimensional diffusion,Jander equation)and a D1 model in the second stage(one-dimensional diffusion).For thefirst and second ther-mal decomposition stages,the Kissinger,Friedman,Flynn-Wall-Ozawa,and Coats–Redfern four methods were applied to determine the activation energy(E=143.72 and 247.01 kJ mol^(-1))and Arrhenius preexponential factor(ln A=26.34 and 42.45 min^(-1)),respectively.Therefore,the study will provide good theoretical guidance for ther-mal stability and thermal transformation application of oleuropein.It will be suitable for low-temperature appli-cations in the cosmetic,food supplement and pharmaceutical industries. | Jiaojiao Yuan Su Tuo Yangyang Liu Jing He Shao-Hwa Hu Junling Tu | 2023 | Journal of Renewable Materials2023，11，8： | 0 |
| 20 | Effect of bicarbonate on CO_(2) electroreduction over cathode catalysts显示文摘CO_(2) electroreduction (CO_(2) ER) using renewable energy is ideal for mitigating the greenhouse effect and closing the carbon cycle. Bicarbonate (HCO_(3)−) is most commonly employed as the electrolyte anion because it is known to facilitate CO_(2) ER. However, its dynamics in the electric double layer remains obscure and requires more in-depth investigation. Herein, we investigate the refined reduction process of bicarbonate by employing in situ attenuated total reflectance surface-enhanced infrared absorption spectroscopy. By comparing the product distributions in Ar-saturated KCl and KHCO_(3) electrolytes, we confirmed CO production from HCO_(3)^(−) in the absence of an external CO_(2) source. Notably, in contrast to an electric compulsion, negatively charged HCO_(3)− anions were found to accumulate near the electrode surface. A reduction mechanism of HCO3− is proposed in that HCO3− is not adsorbed over a catalyst, but may be enriched near the electrode surface and converted to CO_(2) and react over Au and Cu electrodes. The dependence of the CO_(2) ER activity on the local HCO3− concentration was subsequently discovered, which was in turn dependent on the bulk HCO3− concentration and cathodic potential. In particular, the local HCO3− concentration was limited by the cathodic potential, leading to a plateau in the CO_(2) ER activity. The proposed mechanism provides insights into the interaction between the catalyst and the electrolyte in CO_(2) ER. | Wanyu Deng Tenghui Yuan Sai Chen Huimin Li Congling Hu Hao Dong Bo Wu Tuo Wang Jingkun Li Geoffrey A.Ozin Jinlong Gong | 2021 | Fundamental Research2021，1，4： | 0 |
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