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| 1 | Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease显示文摘瞄准:为了调查可溶的被触发的可能的角色,受体在煽动性的肠疾病(IBD ) 的致病在骨髓的上表示了 cells-1 (sTREM-1 ) 。方法:58 个病人被注册;十九个健康志愿者用作控制;8 个病人与 Crohn 的疾病被诊断,并且 31 与 ulcerative。有 Crohn 的疾病和 ulcerative 的病人的临床、内视镜的活动索引分别地被估计。在承认之上,血被取样;sTREM-1 和 TNFalpha 被 thiobarbitourate 试金被免疫分析和 malondialdehyde (MDA ) 测量,在通过一个 HPLC 系统的经过以后。结果:控制,有 Crohn 的疾病的病人和有 ulcerative 的病人的 TNFalpha 的中部的 +/- SE 是 6.02 +/- 3.94, 7.98 +/- 5.08 (P = NS 对控制) ,并且 8.45 +/- 4.15 ng/L (P = 0.018 对控制) 分别地。sTREM-1 的各自的价值是 53.31 +/- 32.93, 735.10 +/- 197.17 (P = 0.008 对控制) 并且 435.82 +/- 279.71 ng/L (P = 0.049 对控制) 。sTREM-1 断然与 Crohn 的疾病活动索引和 ulcerative 的临床、内视镜的活动索引被相关(P = 0.002, 0.001 和 0.009,分别地) 。有 ulcerative 的病人的 sTREM-1 断然与 TNFalpha 被相关(P = 0.001 ) 。结论:sTREM-1 似乎在与肠粘膜的炎性反应的度的关联在 IBD 作为一个新奇调停人表现。 | Michalis Tzivras Vassilios Koussoulas Evangelos J Giamarellos-Bourboulis Dimitrios Tzivras Thomas Tsaganos Pantelis Koutoukas Helen Giamarellou Athanasios Archimandritis | 2006 | World Journal of Gastroenterology2006，12，21： | 17 |
| 2 | Monocytes in systematic inflammatory response syndrome:Differences between sepsis and acute pancreatitis显示文摘AIM: To unravel the differences between systematic in- flammatory response syndrome (SIRS) of acute pancre- atitis compared to the same syndrome in sepsis. METHODS: Twenty-five patients were enrolled, 12 with sepsis and 13 acute pancreatitis. After diagnosis 20 ml blood was sampled. Half were assayed for isolation of monocytes and 10 ml was centrifuged for serum test of tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). Half of monocytes were incubated in the presence of patients’ serum and supernatants were collected. The other half was treated for estimation of optical photom- etry under caspase-3 inhibition. TNFα and IL-6 were es- timated by an enzyme immunoassay. RESULTS: median ± SE of serum IL-6 in septic patients and acute pancreatitis patients was 192.30 ± 35.40 ng/L and 21.00 ± 16.05 ng/L, respectively (P < 0.01). Re- spective values of caspase-3 were 0.94 ± 0.17 pmol/min 104 cells and 0.34 ± 0.09 pmol/min 104 cells (P < 0.05). IL-6 of monocyte supernatants of patients with sepsis was significantly increased after addition of patients’ serum, while that of patients with acute pancreatitis did not show significant difference. CONCLUSION: The data have shown that monocyte activity is different between acute pancreatitis and sepsis. This phenomenon might be explained as a different pathway to the pro-inflammatory cytokines release or could be a novel anti-inflammatory response in acute pancreatitis. | Vassilios Koussoulas Michalis Tzivras Vassiliki Karagianni Ekaterini Spyridaki Diamantis Plachouras Helen Giamarellou Evangelos J Giamarellos-Bourboulis | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 3 | Retinol-binding protein, acute phase reactants and Helicobacter pylori infection in patients with gastric adenocarcinoma显示文摘AIM: To determine the serum levels of c-reactive protein (CRP), transferrin (TRF), a2-macroglobulin (A2M),ceruloplasmin (CER), a1-acid glycoprotein (AAG), prealbumin (P-ALB) and retinol-binding protein (RBP) in gastric carcinoma patients and to explore their possible correlation with underlying Helicobacter pylori (H pylon)infection.METHODS: We measured the serum levels of CRP, TRF,A2M, CER, AAG, P-ALB, and RBP in 153 preoperative patients (93 males; mean age: 63.1±11.3 years) with non-cardia gastric adenocarcinoma and 19 healthy subjects.RESULTS: The levels of CRP, CER, RBP, andAAG in cancer patients were significantly higher than those in healthy controls (P<0.0001), while no difference was found regarding the TRF, P-ALB, and A2M levels. Cancer patients with H pylori infection had significantly lower RBP values compared to non-infected ones (P<0.0001)and also higher values of CRP and AAG (P = 0.09 and P = 0.08, respectively).CONCLUSION: High serum levels of CRP, CER and AAG in cancer patients do not seem to be related to H pylori infection. Retinol-binding protein seems to discriminate between infected and non-infected patients with gastric carcinoma. Further studies are needed to explore if it is directly involved in the pathogenesis of the disease or is merely an epiphenomenon. | Nicolas Tsavaris Christos Kosmas Petros Kopterides Dimitrios Tsikalakis Hlias Skopelitis Fotini Sakelaridi Nikitas Papadoniou Michalis Tzivras Vasilios Balatsos Christos Koufos Athanasios Archimandritis | 2005 | World Journal of Gastroenterology2005，11，45： | 7 |
| 4 | Helicobacter pylori infection as an environmental risk factor for migraine without aura显示文摘 | Konstantina G. Yiannopoulou Athina Efthymiou Kleanthis Karydakis Andreas Arhimandritis Nikolaos Bovaretos Mihalis Tzivras | 2007 | The Journal of Headache and Pain2007，，6： | 2 |
| 5 | The liver in bmce- llosis显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 6 | The prevalence of overgrowth by aerobic bacteria in the small in- testine by small bowel culture: relationship with irritable bowel syndrome显示文摘 | Pyleris E Giamarellos-Bourboulis EJ Tzivras D | 2012 | Dig Dis Sci2012，57，5： | 1 |
| 7 | Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients显示文摘 | Archimandritis A Spiliadis C Tzivras M | 1996 | Ital J Gastroenterol1996，28，7： | 1 |
| 8 | One-week therapy with omeprazole,clarithromycin and metronidazole or omidazole,followed by 3 weeks' treatment with omeprazole,eradicates Helicobacter pylori equally and heals duodenal ulcer显示文摘 | Tzivras M Archimandritis A Balatsos V | 1997 | Eur J Gastroenterol Hepatol1997，9，12： | 1 |
| 9 | The liver in Brucellosis 显示文摘 | Akritidis N Tzivras M Delladetsima I Stefanaki S Moutsopoulos HM Pappas G | 2007 | Clin Gastroenterol Heptol2007，4，： | 1 |
| 10 | Can soluble triggering receptor expressed on myeloid cells(sTREM-1) be considered an anti inflammatory mediator in the pathogenesis of peptic ulcer disease? 显示文摘 | Koussoulas V Tzivras M Giamarellos-Bourboulis EJ | 2007 | Dig Dis Sei2007，52，21： | 1 |
| 11 | Association of polymorphisms of NOD2, TLR4 and CDI4 genes with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma 显示文摘 | Ture-Ozdemir F Gazouli M Tzivras M | 2008 | Anticancer Res2008，28，6： | 1 |
| 12 | The preva- lence of overgrowth by aerobic bacteria in the small intestine by small bowel culture : relationship withirritable bowel syndrome显示文摘 | Pyleris E Giamarellos - Bourboulis E J Tzivras D | 2012 | Dig Dis Sci2012，57，5： | 1 |
| 13 | The liver in brucellosis显示文摘 | Akritidis N M Tzivras I Delladetsima | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 14 | The liver in brucellosis显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 15 | Changes in adaptiveand innate immunity in patients with acute pancreatitis and systemic in-flammatory response syndrome 显示文摘 | Mylona V Koussoulas V Tzivras D | 2011 | Pancreatology2011，11，5： | 1 |
| 16 | Changes in adaptive and innate immunity in patients with acute pancreatitis and systemic in- flammatory response syndrome 显示文摘 | Mylona V Koussoulas V Tzivras D | 2011 | Pancreatology2011，11，5： | 1 |
| 17 | Changes in adap- tive and innate immunity in patients with acute pancreatitis and systemic inflammatory response syndrome 显示文摘 | Mylona V Koussoulas V Tzivras D | 2011 | Pancreatology2011，11，5： | 1 |
| 18 | The liver in brucellosis 显示文摘 | Akritidis N Tzivras M Delladetsima I | 2007 | Clin Gastroenterol Hepatol2007，5，9： | 1 |
| 19 | Clostridium difficile colitis associated with a ‘triple’ regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori显示文摘 | Archimandritis Souyioultzis Katsorida Tzivras | 2008 | Journal of Internal Medicine2008，，3： | 1 |
| 20 | Helicobacter pylori infection as an environmental risk factor for migraine without aura显示文摘 | Konstantina G. Yiannopoulou Athina Efthymiou Kleanthis Karydakis Andreas Arhimandritis Nikolaos Bovaretos Mihalis Tzivras | 2007 | The Journal of Headache and Pain2007，，6： | 1 |
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