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| 1 | Total hepatectomy and liver transplantation as a two-stage procedure for fulminant hepatic failure: A safe procedure in exceptional circumstances显示文摘AIM: To evaluate the outcomes of two-stage liver transplant at a single institution, between 1993 and March 2015.METHODS: We reviewed our institutional experience with emergency hepatectomy followed by transplantation for fulminant liver failure over a twenty-year period. A retrospective review of a prospectively maintained liver transplant database was undertaken at a national liver transplant centre. Demographic data, clinical presentation, preoperative investigations, cardiocirculatory parameters, operative and postoperative data were recorded.RESULTS: In the study period, six two-stage liver transplants were undertaken. Indications for transplantation included acute paracetamol poisoning(n = 3), fulminant hepatitis A(n = 1), trauma(n = 1) and exertional heat stroke(n = 1). Anhepatic time ranged from 330 to 2640 min. All patients demonstrated systemic inflammatory response syndrome in the first post-operative week and the incidence of sepsis was high at 50%. There was one mortality, secondary to cardiac arrest 12 h following re-perfusion. Two patients required re-transplantation secondary to arterial thrombosis. At a median follow-up of 112 mo, 5 of 6 patients are alive and without evidence of graft dysfunciton.CONCLUSION: Two-stage liver transplantation represents a safe and potentially life-saving treatment for carefully selected exceptional cases of fulminant hepatic failure. | Rebeca Sanabria Mateos Niamh M Hogan Dimitri Dorcaratto Helen Heneghan Venkatesh Udupa Donal Maguire Justin Geoghegan Emir Hoti | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 2 | Nicotine as a mitogenic stimulus for pancreatic acinar cell proliferation显示文摘Cell proliferation is an important process in life for growth of normal and cancer cells. The signal transduction pathways activated during this process are strictly regulated. This editorial focuses on the role of nicotine, a mitogen, in the induction of signaling pathways resulting in proliferation of pancreatic tumor cells and compares these events with those in normal acinar cells isolated from the rat pancreas. The data shows striking similarities between these two cellular systems. In addition, the editorial reviews very recent literature of the contribution of MAPK signaling in cell lines associated with human diseases. A prospective cellular model of nicotine induced activation of MAPK cascade is presented. | Parimal Chowdhury Kodetthoor B Udupa | 2006 | World Journal of Gastroenterology2006，12，46： | 3 |
| 3 | Role of angiogenesis and angiogenic factors in acute and chronic wound healing显示文摘Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue.This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment.Vascular endothelial growth factor,angiopoietin,fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis.Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair.In particular integrin(αvβ3)receptors for fibrin and fibronectin,appear to be required for wound angiogenesis:αvβ3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot,and any functional inhibitors ofαvβ3 such as monoclonal antibodies,cyclic RGD peptide antagonists,and peptidomimetics rapidly inhibit granulation tissue formation.In spite of clear knowledge about influence of many angiogenic factors on wound healing,little progress has been made in defining the source of these factors,the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair. | Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Echalasara Govindarama Padmanabha Udupa Sudesh Kumar Udaya Kumar Pragna Rao | 2015 | Plastic and Aesthetic Research2015，2，1： | 3 |
| 4 | Functional significance of erythropoietin receptor on tumor cells显示文摘Erythropoietin (Epo) is the regulator of red blood cell formation. Its receptor (EpoR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EpoR antagonist can reduce the growth of the tumor in vivo. In view of our current knowledge of Epo, its recombinant forms and receptor, use of Epo in cancer patients to enhance the recovery of hematocrit after chemotherapy treatment has to be carefully evaluated. | Kodetthoor B Udupa | 2006 | World Journal of Gastroenterology2006，12，46： | 3 |
| 5 | Fast Surface Tracking in 3D Binary Images显示文摘 | Gordon D Udupa J K | 1989 | Computer Vision Graphics and Image Processing1989，45，2： | 2 |
| 6 | Population structure analysis and determination of neurotoxin content in a set of grass pea (Lathyrus sativus L.) accessions of Bangladesh origin显示文摘Grass pea(Lathyrus sativus L.) is a crop that is considered one of the more resilient to climate change. With protein-rich seeds and leaves, it has strong potential as human food as well as animal feed and fodder. However, genetic improvement in this crop remains stagnant owing to the poor characterization of its genetic resources. In this study, we characterized 118 accessions of grass pea with 18 EST-SSR markers. A total of 118 accessions, 101 of L. sativus(100 cultivated accessions from Bangladesh and one wild accession) and 17 wild accessions of other Lathyrus species, were used. A total of 67 alleles were detected, with an average of 3.72 alleles per locus and average polymorphism information content of 0.52. A dissimilarity matrix was formed and hierarchical cluster analysis performed using the UPGMA method grouped genotypes into four main clusters. Cluster analysis based on the genetic dissimilarity revealed a clear grouping of the 100 cultivated and 18 wild accessions into four main groups. Group I consisted of 20 accessions with high β-N-oxalyl-L-α,β-diaminopropionic acid(β-ODAP) concentration. Of these 20 accessions, 17 were wild accessions. Only one wild accession(L. cicera) was clustered in group II, which contained 35 accessions. Most of the group II accessions contained low β-ODAP. Group III was represented by 34 accessions, many of them with high β-ODAP. Group IV consisted of 29 accessions, a few of which had very high β-ODAP concentrations. Analysis of molecular variance of the microsatellite data showed significantly higher values of molecular variance between(83%) than within(17%) populations. These characterized accessions will be useful in grass pea breeding programs. | Priyanka Gupta Sripada M. Udupa Debjyoti Sen Gupta Jitendra Kumar Shiv Kumar | 2018 | The Crop Journal2018，6，4： | 2 |
| 7 | Protective effect of Prostane in experimental prostatic hyperplasia in rats显示文摘Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on ,5a-reductase inhibition, a-adrenergie anta-gonistic activity and testosterone-induced prostatic hypeqllasia. Methods: 5a-reductase inhibition was evaluated usingrat prostate hornogeante as an enzyme source. Adrenergic antagonistic' activity was evaluated using isolated rat vas def-erens. Experimental prostatic hyperplasia was induced in rats by' giving testosterone 3 mg/kg sc for 21 days. Re-suits: Prostane dose-dependently inhibited 5a-reductase aetivity and exhibited a-adrenergic antagonistic activity. Treat-ment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, theepithelial height and the stroinal proliferation in experimental prostatic hypertrophy. Conclusion: Prostane is effectivein the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatichypertrophy after necessary toxicological evaluations. ( Asian J Androl 1999 Dec ; l : 175 - t79 ) | S.K.Mitra R.Sundaram A.R.Mohan S.Gopumadhavan M.V.Venkataranganna Udupa Venkatesha S.J.Seshadri S.D.Autrulikar | 1999 | Asian Journal of Andrology1999，1，4： | 2 |
| 8 | An Objective comparison of 3-D image interpolation methods显示文摘 | Udupa J K | 1998 | IEEE Trans Med Image1998，17，4： | 1 |
| 9 | An improved process synthesis of 2, 2'-dichlorohydrazobenzene 显示文摘 | Udupa K S Subrarnanian G S | 1961 | Bulletin de 1'' Academie Polonaise des Sciences (Serie des Sciences Chimiques )1961，9，9： | 1 |
| 10 | Fuzzy connectedness and objectdefinition: theory, algorithms, and applications in image segmentation显示文摘 | Udupa J K Samarasekera S | 1996 | Graphical models and image processing1996，58，3： | 1 |
| 11 | Analysis of volumetric image显示文摘 | Goshtasby A A Sonka M Udupa J K | 2000 | Computer Vision gz Image Under- standing2000，77，： | 1 |
| 12 | An ultra-fast usersteered image segmentation paradigm:Live wire on the fly显示文摘 | Falcao A X Udupa J K Miyazawa F K | 2000 | IEEE Transactions on Medical Imaging2000，19，1： | 1 |
| 13 | Shape-based interpolation ofmultidimensional grey-level images 显示文摘 | Grevera G J Udupa J K | 1996 | IEEE Transactions onMedical Imaging1996，15，6： | 1 |
| 14 | Software-based Resolver-to-digit- al Conversion Using a DSP显示文摘 | S Sarma V K Agrawal S Udupa | 2008 | IEEE Transactions on Industrial E- ltronics2008，55，1： | 1 |
| 15 | Medical image segmentation by combining graph cuts and oriented active appearance mndels 显示文摘 | Chen X Udupa 1 K Bagci U | 2012 | IEEE Transaction on Image Processing (S1057-7149)2012，21，4： | 1 |
| 16 | Synergistic arc- weight estimation for interactive image segmentation using graphs 显示文摘 | Mirandaa PAV Facaoa AX Udupa JK | 2011 | Computer Vision and Image Understanding2011，114，1： | 1 |
| 17 | Fuzzy connectedness and image segmentation显示文摘 | Udupa J K Saha P K | 2003 | Proceedings of the IEEE2003，91，10： | 1 |
| 18 | Fuzzy connectedness and object definition: theory, algorithm and applications in image segmentation 显示文摘 | Udupa J K Samarasekera S | 1996 | Journal of Graphical Models and Image Processing1996，58，3： | 1 |
| 19 | Multiple Sclerosis Lesion Qualification Using Fuzzy-Connectedness Principle显示文摘 | Udupa J K Wei L Samarasekera S | 1997 | IEEE Trans on Med Imaging1997，16，5： | 1 |
| 20 | Scale-based fuzzy connectedimage segmentation: theory, algorithms, and validation显示文摘 | Saha P K Udupa J K Odhner D | 2000 | ComputerVision and Image Understanding2000，77，2： | 1 |
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