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| 1 | Neoadjuvant chemotherapy for locally advanced cervical cancer显示文摘Neoadjuvant chemotherapy followed by surgery(NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy(NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials(RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy(CCRT) has markedly improved the outcome of radiotherapy(RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT. | Takashi Iwata Azumi Miyauchi Yukako Suga Hiroshi Nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki | 2016 | Chinese Journal of Cancer Research2016，28，2： | 20 |
| 2 | Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation显示文摘AIM To investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation(GCED).METHODS We retrospectively investigated data on 6 cases of early stage GCED and 186 cases of early stage conventional gastric cancer(CGC: well or moderately differentiated adenocarcinoma) who underwent endoscopic submucosal dissection or endoscopic mucosal resection from September 2011 to February 2015 in our hospital.GCED was defined as a tumor having a primitive intestine-like structure composed of cuboidal or columnar cells with clear cytoplasm and immunohistochemical positivity for either alpha-fetoprotein, Glypican 3 or SALL4. The following were compared between GCED and CGC: age, gender, location and size of tumor, macroscopic type, ulceration, depth of invasion, lymphatic and venous invasion, positive horizontal and vertical margin, curative resection rate.RESULTS Six cases(5 males, 1 female; mean age 75.7 years; 6 lesions) of early gastric cancer with a GCED component and 186 cases(139 males, 47 females; mean age 72.7 years; 209 lesions) of early stage CGC were investigated. Mean tumor diameters were similar but rates of submucosal invasion, lymphatic invasion, venous invasion, and non-curative resection were higher in GCED than CGC(66.6% vs 11.4%, 33.3% vs 2.3%, 66.6% vs 0.4%, 83.3% vs 11% respectively, P < 0.01). Deep submucosal invasion was not revealed endoscopically or by preoperative biopsy. Histologically, in GCED the superficial mucosal layer was covered with a CGC component. The GCED component tended to exist in the deeper part of the mucosa to the submucosa by lymphatic and/or venous invasion, without severe stromal reaction. In addition, Glypican 3 was the most sensitive marker for GCED(positivity, 83.3%), immunohistochemically.CONCLUSION Even in the early stage GCED has high malignant potential, and preoperative diagnosis is considered difficult. Endoscopists and pathologists should know the clinicopathological features of this highly malignant type of cancer. | Kohei Matsumoto Hiroya Ueyama Kenshi Matsumoto Yoichi Akazawa Hiroyuki Komori Tsutomu Takeda Takashi Murakami Daisuke Asaoka Mariko Hojo Natsumi Tomita Akihito Nagahara Yoshiaki Kajiyama Takashi Yao Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，36： | 20 |
| 3 | 保留C_2棘突半棘肌附着的颈椎管扩大椎板成形术显示文摘目的:观察完整保留C2棘突半棘肌附着的颈椎管扩大椎板成形术的手术疗效。方法:A组27例行改良颈椎板成形术,即显露时保留半棘肌在C2棘突上的附着,切除C3椎板,C4~C7双开门术式。B组33例行常规颈椎板成形术,即分离切断C2棘突半棘肌附着,关闭时缝合重建,C3~C7双开门成形术式。比较两组手术时间、出血量、术后神经功能、并发症、颈椎曲度和屈伸活动度(ROM)、病人自我评价。JOA计分法评价神经功能、Cobb’s法测量颈椎曲度和ROM。结果:所有病例随访至少1年,A、B组术后JOA评分平均改善率分别为63.01%、60.83%(P>0.05)。手术时间A、B组分别123±17.4min、175±12.7min,出血量分别380±18.6ml、564±21.5ml;A组较B组手术时间短、出血量少(P<0.05)。术后1年A、B组ROM分别保留术前的81.6%和65.3%(P<0.01);A组无后凸畸形、手术并发症少、局部症状轻微。结论:改良颈椎管扩大椎板成形术脊髓减压满意,手术时间短、出血量少,无严重并发症;而且有助于早期颈椎功能锻炼、维持良好颈椎曲度和ROM。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 廖威明 | 2006 | 中国临床解剖学杂志2006，24，5： | 9 |
| 4 | What types of early gastric cancer are indicated for endoscopic ultrasonography staging of invasion depth?显示文摘AIM To clarify the diagnostic efficacy and limitations of endoscopic ultrasonography(EUS) and the characteristics of early gastric cancers(EGCs) that are indications for EUS-based assessment of cancer invasion depth.METHODS We retrospectively investigated the cases of 153 EGC patients who underwent conventional endoscopy(CE) and EUS(20 MHz) before treatment.RESULTS We found that 13.7% were 'inconclusive' cases with low-quality EUS images, including all nine of the cases with protruded(0-I)-type EGCs. There was no significant difference in the diagnostic accuracybetween CE and EUS. Two significant independent risk factors for misdiagnosis by EUS were identified-ulcer scarring [UL(+); odds ratio(OR) = 4.49, P = 0.003] and non-indication criteria for endoscopic resection(ER)(OR = 3.02, P = 0.03). In the subgroup analysis, 23.1% of the differentiated-type cancers exhibiting SM massive invasion(SM2) invasion(submucosal invasion ≥ 500 μm) by CE were correctly diagnosed by EUS, and 23.1% of the undifferentiated-type EGCs meeting the expanded-indication criteria for ER were correctly diagnosed by EUS.CONCLUSION There is no need to perform EUS for UL(+) EGCs or 0-I-type EGCs, but EUS may enhance the pretreatment staging of differentiated-type EGCs with SM2 invasion without UL or undifferentiated-type EGCs revealed by CE as meeting the expanded-indication criteria for ER. | Jiro Watari Shigemitsu Ueyama Toshihiko Tomita Hisatomo Ikehara Kazutoshi Hori Ken Hara Takahisa Yamasaki Takuya Okugawa Takashi Kondo Tomoaki Kono Katsuyuki Tozawa Tadayuki Oshima Hirokazu Fukui Hiroto Miwa | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，16： | 8 |
| 5 | Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis显示文摘AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same sites.WLI images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic features.Likewise,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color model.WLI and AFI endoscopic scores from the same sites were compared.Histological evaluation of biopsies was according to the Riley Index.RESULTS:Relative to red(r=0.52,P<0.01)or blue(r=0.56,P<0.01)color component,the green color component of AFI(r=-0.62,P<0.01)corresponded more closely with mucosal inflammation sites.There were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P<0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P<0.01).The WLI scores for 'vascu-lar patterns'(r=-0.65,P<0.01),'edema'(r=-0.62,P<0.01),histology scores for 'polymorphonuclear cells in the lamina propria'(r=-0.51,P<0.01)and 'crypt architectural irregularities'(r=-0.51,P<0.01)showed correlation with the green color component of AFI.There were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within MES-0.As the severity of the mucosal inflammation increased,the green color component of AFI decreased.The AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of UC.CONCLUSION:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images. | Taro Osada Atsushi Arakawa Naoto Sakamoto Hiroya Ueyama Tomoyoshi Shibuya Tatsuo Ogihara Takashi Yao Sumio Watanabe | 2011 | World Journal of Gastroenterology2011，17，46： | 5 |
| 6 | 前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤的疗效比较显示文摘目的比较前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤的临床疗效。方法回顾性分析2000年8月~2005年10月采用前路减压、椎体间融合内固定(A组,n=11)和后路短缩截骨术(B组,n=14)治疗的骨质疏松性胸腰椎骨折合并神经损伤患者的临床和影像学资料。疼痛视觉模拟评分及日本整形外科学会评分法评估临床结果,Frankel分级评价神经功能,X线片评估融合及后凸矫正,并观察手术并发症。结果所有患者得到14~48个月(平均27个月)随访,末次随访A、B两组疼痛视觉模拟评分分别由术前9.3、8.9分减少到3.2、2.5分;JOA评分及其平均恢复率两组差异无统计学意义(P〉0.05);Frankel分级A、B组分别6例、5例由术前C级恢复到D或E级,5例、9例由D级恢复到E级,分别改善1.5、1.7级;A、B组后凸角分别由术前平均36.9°、37.3°矫正到术后9.3°、6.5°和末次随访的14.5°、11.7°,术后两组差异有统计学意义(P〈0.05)。两组均无内固定相关并发症。结论前、后路手术治疗骨质疏松性胸腰椎骨折合并神经损伤临床疗效无显著差异;对于后凸角度较大者,宜选择后路短缩截骨术。 | 龙厚清 Kazumasa Ueyama 刘少喻 黄阳亮 陈立言 李佛保 | 2007 | 中华创伤骨科杂志2007，9，9： | 5 |
| 7 | A white opaque substance-positive gastric hyperplastic polyp with dysplasia显示文摘The endoscopic findings of gastric hyperplastic polyps (HPs) with dysplasia have not been well-defined, and the clinical significance of these lesions, including their malignant potential, is unclear. In this report, we describe a case of a white opaque substance (WOS)positive gastric HP with dysplasia. A 76-year-old woman was referred to our hospital for endoscopic resection of a gastric HP. Upper endoscopy revealed a 25-mm whitish and reddish polypoid lesion on the greater curvature in the lower third of the stomach. The whitish part was diagnosed as a WOS using conventional and magnifying endoscopy with narrow band imaging. An examination of the biopsy specimen indicated that the lesion was a typical gastric HP. However, because of its color and the presence of a WOS, we suspected that this lesion was an atypical gastric HP. Therefore, we performed a polypectomy. Histopathologically, diffuse lowto high-grade dysplasia was found on the surface of the polyp. We performed immunohistochemical staining using a monoclonal antibody specific for adipophilin as a marker of lipid droplets (LDs). LDs were detected in approximately all of the neoplastic cells, especially in the surface epithelium of the intervening apical parts and were located in the subnuclear cytoplasm of the neoplastic cells. According to endoscopic and histopathological findings, the WOS-positive epithelium indicated dysplasia of the gastrointestinal phenotype, which could absorb lipids. The presence of a WOS in a gastric HP may be considered an endoscopic finding that is predictive of the neoplastic transformation of a gastric HP. We suggest that a WOS-positive gastric HP should be resected endoscopically to investigate its neoplastic transformation. | Hiroya Ueyama Kenshi Matsumoto Akihito Nagahara Ryosuke Gushima Takuo Hayashi Takashi Yao Sumio Watanabe | 2013 | World Journal of Gastroenterology2013，19，26： | 4 |
| 8 | 后路短缩截骨内固定治疗骨质疏松性症状性陈旧胸腰椎骨折显示文摘目的:观察后路短缩截骨内固定治疗骨质疏松性症状性陈旧胸腰椎骨折的疗效。方法:回顾18例后路短缩截骨内固定治疗的陈旧性骨质疏松性胸腰椎骨折患者的临床和影像学资料,平均年龄67岁。T12、L1、L2节段分别为8例、5例、5例,其中骨折不愈合4例,后凸畸形并神经功能障碍11例,爆裂骨折合并神经压迫保守治疗无效3例。应用疼痛视觉模拟(VAS)评分及JOA评分法评估临床结果,Frankel分级评价神经功能状态,X线评估融合及后凸状况,并观察手术并发症。结果:平均手术时间213min,平均出血量780ml。随访27个月(19~48个月),末次随访时VAS评分由术前8.9分减少到2.5分,JOA评分(25.1±4.1分)显著优于术前(12.7±3.6分,P<0.001);Frankel分级5例由术前C级恢复到D或E级,9例由D级恢复到E级;平均后凸角由术前37.3°矫正到术后6.5°,末次随访时为13.7°。无内固定相关并发症。结论:后路短缩截骨内固定是治疗骨质疏松性症状性陈旧胸腰椎骨折的有效方法,但应严格手术指征。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 廖威明 | 2006 | 中国脊柱脊髓杂志2006，16，10： | 4 |
| 9 | 后路非融合固定在腰椎间盘退变性疾病中的临床应用显示文摘目的 评估后路非融合固定(Graf技术)应用于腰椎间盘退变性疾病的疗效。方法分析13例非融合固定(A组)和21例融合固定(B组)治疗单节段腰椎退行性病变的临床和影像学资料。视觉模拟评分(VAS)、日本整形外科学会(JOA)评分和ODI功能评价评估临床疗效,腰椎过伸和过屈、侧位X线片评估腰椎活动度和腰椎前凸角(Cobbs法),观察两组手术并发症。结果 平均随访19个月(12~29个月),末次随访A、B两组VAS评分分别由术前9.4、9.1分减少到2.1、3.6分;JOA评分均显著优于术前(P〈0.001),两组无显著性差异(P〉0.05);A组术后ODI优良率93%,B组71%,A组显著优于B组(P〈0.05)。结论 后路非融合固定是治疗腰椎间盘退变性疾病的有效方法,与融合固定相比,可以获得满意的临床疗效和保留一定的腰椎活动度。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 廖威明 | 2008 | 中国骨与关节损伤杂志2008，23，6： | 3 |
| 10 | Preserving the C7 spinous process with its muscles attached: effect on axial symptoms after cervical laminoplasty显示文摘 | Kenji Kowatari Kazumasa Ueyama Akio Sannohe Yoshihito Yamasaki | 2009 | Journal of Orthopaedic Science2009，，3： | 2 |
| 11 | Epidermal growth factor receptor expression in human pancreatic cancer:Significance for liver metastasis显示文摘 | Kosuke Tobita Hiroshi Kijima Shoichi Dowaki Hiroyuki Kashiwagi Yasuo Ohtani Yasuhisa Oida Hitoshi Yamazaki Masato Nakamura Yoshito Ueyama Makiko Tanaka Sadaki Inokuchi Hiroyasu Makuuchi | 2003 | International Journal of Molecular Medicine2003，，3： | 2 |
| 12 | 改进维修的研究显示文摘研究和开发了新的检测方法和诊断方法 ,以延长铁路运输设备、零部件和材料的使用寿命。介绍了日本铁路技术研究所 ( RTRI)在改进维修技术方面所做的研究工作。 | Katsuyoshi Ueyama 陈宁 | 2002 | 国外机车车辆工艺2002，，1： | 2 |
| 13 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 14 | Mallory-Weiss tear during gastric endoscopic submucosal dissection显示文摘A 78-year-old woman was referred to our department for treatment of an early gastric cancer. Esophagogastroduodenoscopy (EGD) demonstrated a flat elevated lesion and a polypoid lesion on the greater curvature of the antrum. Histological analysis of, endoscopic biopsy samples taken from these lesions revealed an adenocarcinoma and a hyperplastic polyp, respectively. ESD was conducted for removal of the lesions. Carbon dioxide (CO2) in- stead of room air was used for insufflation, and the patient was adequately sedated without struggling or vomiting during the treatment. No significant bleeding from the lesion was observed during ESD, but fresh blood was identified endoscopically. Surprisingly, a Mallory- Weiss tear with active bleeding was detected on the lesser curvature of the gastric corpus. A total of eight hemoclips were applied for hemostasis. Both lesions were completely removed en bloc, and no bleeding or perforation developed after ESD. Histologically, the first lesion was apapillary carcinoma limited to the mucosal layer and without lymphovascular invasion or involvement of the surgical margins, while the second lesion was a benign hyperplastic polyp. | Hiroki Hongou Kuangi Fu Hiroya Ueyama Taiji Takahashi Tsutomu Takeda Akihisa Miyazaki Sumio Watanabe | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 2 |
| 15 | 限制性和动力性颈椎前路钢板对颈椎矢状位曲度的影响显示文摘目的:比较限制性(Constrained)和动力性(Dynamic)颈椎前路钢板融合率、对融合节段及全颈椎矢状面曲度影响。方法:回顾分析97例(C组59例;D组38例)颈椎前路钢板内固定术后的影像学资料,Cobb's法测量颈椎侧位X线片上融合节段和C3~C7矢状位曲度、融合节段前柱高度,比较其术后即刻及随访末期参数的变化。连续骨小梁通过融合区、X线动态侧位片显示融合节段棘突顶点间距离无变化判定为融合。结果:平均随访16.9个月,C、D组融合率分别为91.6%、97.3%。C组融合节段前凸角丢失单节段为1.17°(0~2.9°)、双节段为1.83°(0~3.5°),D组单节段2.57°(0.5°~4.9°)、双节段3.59°(1°~6.1°),两组有显著性差别(P<0.001)。C、D两组全颈椎矢状面曲度术后和随访末比较无显著差异。C组融合节段前柱高度丢失单节段为1.39mm(0.4~2.9mm)、双节段2.37mm(0.6~4.7mm);D组单节段高度丢失为1.77mm(0.7~3.1mm)、双节段为3.54mm(0.9~5.5mm),与C组相比无显著性差异(P>0.05)。结论:动力性颈椎前路钢板可获得较高的融合率,与限制性钢板相比,融合节段前凸角丢失和前柱高度丢失虽然较大,但不影响整个颈椎的前凸角度。 | 龙厚清 Kazumasa Ueyama 刘少喻 李佛保 万勇 陈立言 | 2008 | 中国临床解剖学杂志2008，26，5： | 2 |
| 16 | Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome p450 1A2 in rats显示文摘 | Nadai, M Kato, M Yasui, K Kimura, M Zhao, YL Ueyama, J Tsunekawa, Y Yoshizumi, H Hasegawa, T | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 17 | Alterations in cardiac tissue of paitient with chronic atrial fibrillation 显示文摘 | Ohkusa T Ueyama T Yamada J | 2000 | Circulation2000，101，： | 1 |
| 18 | Clinical significance and reproducibility of new arterial distensibility index显示文摘 | Kubozono T Miyata M Ueyama K | 2007 | Cir J2007，71，1： | 1 |
| 19 | Alterations in cardiac sarcoplasmic reticulum Caz+ regulatory proteins in the atrial tissue of patients with chronic atrial fibrillation显示文摘 | Ohkusa T Ueyama T Yamada J | 1999 | J Am Coil Cardiol1999，34，1： | 1 |
| 20 | Effects of crystalloid and colloid preload on blood volume in the parturient undergoing spinal anesthesia for elective Cesarean section显示文摘 | Ueyama H He YL Tanigami H | | 0，，06： | 1 |
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