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| 1 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 2 | Expression oftype 2 nitric oxide synthase and vascular endothelialgrowth factor in oral dysplasia 显示文摘 | BRENNAN P A UMAR T WILSON A W | 2002 | J Oral MaxillofacSurg2002，60，12： | 1 |
| 3 | Expression of vascular endo- thelial growth factor in basal cell carcinoma and cutaneous squamous cell carcinoma of the head and neck 显示文摘 | Bowden J Brennan PA Umar T | 2002 | J Cutan Pathol2002，29，10： | 1 |
| 4 | Expression of type 2 nitric oxide synthase and vascular endothelial groeth factor in oral dysplasia 显示文摘 | Brennan PA Umar T Wilson AW | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
| 5 | Head and neck pilomatricoma: an analysis of 201 cases显示文摘 | O'Connor N Patel M Umar T et aI | 2010 | Br J Oral Maxillofac Surg2010，49，5： | 1 |
| 6 | Effect on neem formulations on reproduction and oviposition of rice hoppers Nilapavata lugens,Sogatella furcifera and Nephotettix virescens 显示文摘 | umar K Mahesh Krishnaiah N V Lingaiah T | 2001 | Pesticide Research Journal2001，13，1： | 1 |
| 7 | Expression of type 2 nitric oxide synthase and P21 in oral squamous cell carcinoma 显示文摘 | Brennan PA Palacios-Callender M Umar T | 2002 | Int J Oral Maxillofac Surg2002，31，2： | 1 |
| 8 | Expression of type 2 nitric oxide synthase and p21 in oral squamous cell carcinoma显示文摘 | Brennan P A Palacios-Callender M Umar T | 2002 | Int J Oral Maxillofac Surg2002，31，12： | 1 |
| 9 | Head and neck pilomatricom a: an analysis of 201 cases显示文摘 | O'Connor N Patel M Umar T | 2011 | Br J Oral Maxillofac Surg2011，49，： | 1 |
| 10 | Expression of nitric oxide synthase in pleomorphic adenomas of the parotid 显示文摘 | Brennan PA Umar T Buckley J | 2000 | Br J Oral Maxillofac Surg2000，38，4： | 1 |
| 11 | An immunohistochemistry study to assess inducible nitric oxide synthase expression in oral lichen planus显示文摘 | Umar T Palacios-Callender M | 2000 | Oral Pathol Med2000，29，： | 1 |
| 12 | Expression of nitric oxide synthase in pleomorphic adenomas of the parotid显示文摘 | Umar T Buckley J | 2000 | Br J Oral Maxillofac Surg2000，38，4： | 1 |
| 13 | MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment 显示文摘 | UMARS K AMURA K NEIM T | 2004 | Briefings in Bioin formatics2004，5，： | 1 |
| 14 | MEGA3 :Integrated software for molecular evolutionary genetics analysis and sequence alignment 显示文摘 | UMARS K AMURA K NEIM T | 2004 | Briefings in Bioinformatics2004，5，： | 1 |
| 15 | Small cell carcinoma of the prostate显示文摘 | Umar S A Umar S A MacLennan G T | 2009 | J Urol2009，181，： | 1 |
| 16 | Head and neck piloma- tricoma: an analysis of 201 cases 显示文摘 | O'Connor N Patel M Umar T | 2011 | Br J Oral Maxillofac Surg2011，49，5： | 1 |
| 17 | Effects of Cydonia oblonga Miller extracts on blood hemostasis, coagulation and fi- brinolysis in mice, and experimental thrombosis in rats 显示文摘 | Zhou W T Abdurahman A Umar A | 2014 | J Ethnopharmacol2014，154，1： | 1 |
| 18 | Molecular characterization of LopB,yhe second lactoferrin binding protein of Neisseria menigitidis显示文摘 | Petterson A Prinz T Umar A | 1998 | Mol Microbiol1998，27，： | 1 |
| 19 | Nonlinear response of a moored buoy显示文摘 | Umar A Datta T K | 2003 | Ocean Engineering2003，，30： | 1 |
| 20 | Expression of type 2 nitric oxide synthase and vascular endothelial growth factor in oral dysplasia 显示文摘 | BrennanPA Umar T Wilson AW | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
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