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| 1 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 2 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 3 | Long-term efficacy of pelvic floor re-education with EMG-controlled biofeedback显示文摘 | Katharina Jundt Ursula M Peschers Thomas Dimpfl | 2002 | European Journal of Obstetrics and Gynecology2002，，2： | 2 |
| 4 | Endocrine regulation of energy metabolism:Review of pathobiochemical and clinical chemical aspects of leptin,ghrelin,adiponectin,and resistin显示文摘 | Ursula M Axel MG | 2004 | Clini Chemi2004，50，： | 1 |
| 5 | Photodynamic therapy for symptomatic choroidal hemangioma显示文摘 | Ursula M Schmidt-Erfurth Stephan Michels Christine Kusserow Bernhard Jurklies Albert J Augustin | 2002 | Ophthalmology2002，，12： | 1 |
| 6 | Biosynthesis of modified peptide antibiotic nosiheptide in Streptomyces actuosus显示文摘 | Ursula M Knagga A R Reiko T | 1993 | JAm Chem Soc1993，115，17： | 1 |
| 7 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 8 | Biosynthesis ofmodified peptide antibiotic nosiheptide in Streptomyces actuosus显示文摘 | Ursula M Knagga A R Reiko T | 1993 | JAm Chem Soc1993，115，17： | 1 |
| 9 | Rapid Detection of Herpes- Simplex Virus and Varieella-Zoster Virus Infections by Real-Time PCR 显示文摘 | Manfred W Ursula M K Frank T | 2003 | J Clin Mierobiol2003，41，4： | 1 |
| 10 | Biosynthesis of modified peptide antibiotic nosiheptide in Streptomyces actuosus显示文摘 | Ursula M Knagga AR Reiko T | 1993 | Am Chem Soc1993，115，17： | 1 |
| 11 | Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice显示文摘 | Ursula M Karl F Spanaus KS | 1997 | Immunology1997，27，： | 1 |
| 12 | Endocrine regulation of energy metabolism:Review of pathobiochemical and clinical chemical aspects of leptin,ghrelin,adiponectin,and resistin显示文摘 | Ursula M Axel MG | 2004 | Clin Chem2004，50，9： | 1 |
| 13 | Association between ghrelin gene variations and blood pressure in subiects with impaired glucose tolerance显示文摘 | Ursula M Marjukka K Jaana L | 2006 | Am J Hypertens2006，19，9： | 1 |
| 14 | Antioxidant activity of chlorophylls and their derivatives 显示文摘 | Ursula M Rosa M C Patricia Sinnecker | 2005 | Food Research International2005，38，： | 1 |
| 15 | HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects显示文摘 | Simone GS Ursula M Fernando B | 2008 | J Pharmacol Exp Ther2008，324，： | 1 |
| 16 | Regional mean myocardial velocity estimation by real-time color doppler myocardial imaging:a new technique for quantifying regional systolic function显示文摘 | Ursula M Wilkenshoff Sovany A | 1998 | J Am Soc Echocardiogr1998，11，3： | 1 |
| 17 | Automatic Representation of Binary Images显示文摘 | Carlos A Carbrelli Ursula M Molter | 1990 | IEEE TRANSACTIONS ON PATTERN ANALYSIS ANS MACHINE INTELLIGENCE1990，12，12： | 1 |
| 18 | Effects of verteporfin therapy on central visual field function显示文摘 | Ursula M Schmidt-Erfurth Hanno E Naim T | 2004 | Ophthalmology2004，11，5： | 1 |
| 19 | Association between Ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance显示文摘 | Ursula M Marjukka K Jaana L | 2006 | Am J Hypertens2006，19，9： | 1 |
| 20 | Biobleaching of high quality pulps with laccase mediator system Influence of treatment time and oxygen supply显示文摘 | Ursula Fillat M Blanca Ronce | 2009 | Biochemical Engineering Journal2009，，44： | 1 |
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