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| 1 | USING DISPLACED CONE REPRESENTATION IN DEA MODELS FOR NONDOMINATED SOLUTIONSIN MULTIOBJECTIVE PROGRAMMING显示文摘Concepts revolving around 'displaced cones' are used to extend the ideas of nondominated solutions in multiobjective programming. Necessary and sufficient conditions are formed around the additive models of DEA to idelltify nondominated solutions. This provdes a basis for effecting contacts with other disciplines and other parts of DEA. | W. W. Cooper (Graduate School Of Business, University of Texas at Austin, Austin, Texas, USA 78712-1174)WEI Quanling (Department of Information Management, People’s University of China, Beliing 100872, China) G. Yu (Department of MSIS, University of Texas | 1997 | Systems Science and Mathematical Sciences1997，10，1： | 17 |
| 2 | Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss显示文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics. | LIU Xin,1 DAI Pu,1* HUANG Deliang,1 YUAN Huijun,1 LI Weiming,1 YU Fei,1 ZHANG Xin,1 KANG Dongyang,1 CAO Juyang,1 YANG Weiyan,1 HAN Dongyi,1 JIN Zhengce2, GUAN Minxin3 1. Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China2. Weihai Aomaier Gene Technological CO.,LTD.,Weihai,Shandong 264200, China.3. Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA | 2006 | Journal of Otology2006，1，1： | 7 |
| 3 | Molecular pathogenetic mechanism of maternally inherited deafness显示文摘 | GUAN Min - XinDivision and Program in Human Genetics and Center for Hearing and Deafaess Research,Cincinnati Children’s Hospital Medical Center, and Department of Pediatrics, Universityof Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA | 2003 | 中华耳科学杂志2003，1，3： | 6 |
| 4 | 八乙墓卟啉和四苯基卟啉合钌(Ⅱ)及锇(Ⅱ)的二氧加合物的红外光谱显示文摘OEP(八乙基卟啉阴离子)和TPP(四苯基卟啉阴离子)合钌(Ⅱ)和锇(Ⅱ)的二氧加合物由matrix分离技术得到(T=20-43K,P=10-5-10-6torr).为了确定v(O2)带的归属应用了同位素取代法16O2/18O2.IR谱说明对于钌的两种加合物(指OEP和TPP)都有两种异构体,其V(16O2)频率为:Ru(OEP)O2,1141和1103cm-1;Ru(TPP)O2,1167和1114cm-1.Os(TPP)O2只生成一种异构体,v(16O2)=1090cm-1,异构体v(16O2):[Ru(OEP)O2],1141cm-1,[Ru(TPP)O2],1167cm-1,这些加合物约在100K时分解,它们的结构指定为endon,而异构体[Ru(OEP)O2],1103cm-1,[Ru(TPP)O2],1114cm-1和[Os(TPP)O2],1090cm-1,在240—270K分解,它们的结构指定为桥联二聚体.在加合物中,将OEP换成TPP引起的钌加合物v(O2)频率的改变比铁和钴加合物更大.v(O2)相对强度的变化顺序为:Fe(Ⅱ)→Ru(Ⅱ)→Os(Ⅱ). | Lewandowski, W.(Institute of General Chemistry. warsaw Agricultural University.SGGW. 02-528 Warsaw, Rakowiecka 26/30, Poland)(Matrix isolation IR spectra were obtained during author’s stay at the Marquette University, Milwaukee, WI 53233(USA). | 1994 | 无机化学学报1994，10，1： | 4 |
| 5 | Mitochondrial DNA Mutations Associated with Aminoglycoside Ototoxicity显示文摘The mitochondrial 12S rRNA has been shown to be the hot spot for mutations associated with both aminoglycoside-induced and non-syndromic hearing loss. Of all the mutations, the homoplasmic A1555G and C1494T mutations at a highly conserved decoding region in the 12S rRNA have been associated with aminoglycoside-induced and non-syndromic hearing loss in many families worldwide. The A1555G or C1494T mutation is expected to form novel 1494C-G1555 or 1494U-A1555 base-pair at the highly conserved A-site of 12S rRNA. These transitions make the secondary structure of this RNA more closely resemble the corresponding region of bacterial 16S rRNA. Thus, the new U-A or G-C pair in 12S rRNA created by the C1494T or A1555G transition facilitates the binding of aminoglycosides, thereby accounting for the fact that the exposure to aminoglycosides can induce or worsen hearing loss in individuals carrying these mutations. Furthermore, the growth defect and impairment of mitochondrial translation were observed in cell lines carrying the A1555G or C1494T mutation in the presence of high concentration of aminoglycosides. In addition, nuclear modifier genes and mitochondrial haplotypes modulate the phenotypic manifestation of the A1555G and C1494T mutations. These observations provide the direct genetic and biochemical evidences that the A1555G or C1494T mutation is a pathogenic mtDNA mutation associated with aminoglycoside-induced and nonsyndromic hearing loss. Therefore, these data have been providing valuable information and technology to predict which individuals are at risk for ototoxicity, to improve the safety of aminoglycoside antibiotic therapy, and eventually to decrease the incidence of deafness. | GUAN Min-Xin Division of Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA | 2006 | Journal of Otology2006，1，2： | 3 |
| 6 | Nonlinear dynamics of self-oscillating polymer gels显示文摘Self-oscillating polymer gels driven by Belousov-Zhabotinsky (BZ) chemical reaction are a new class of functional gels that have a wide range of potential applications (e.g., autonomously functioning membranes, actuate artificial muscles). However, the precise control of these gels has been an issue due to limited investigations of the influences of key system parameters on the characteristics of BZ gels. To address this deficiency, we studied the self-oscillating behavior of BZ gels using the nonline-ar dynamics theory and an Oregonator-like model, with focus placed upon the influences of various system parameters. The analysis of the oscillation phase indicated that the dynamic response of BZ gels represents the classical limit cycle oscillation. We then investigated the characteristics of the limit cycle oscillation and quantified the influences of key parameters (i.e., ini-tial reactant concentration, oxidation and reduction rate of catalyst, and response coefficient) on the self-oscillating behavior of BZ gels. The results demonstrated that sustained limit cycle oscillation of BZ gels can be achieved only when these key pa-rameters meet certain requirements, and that the pattern, period and amplitude of the oscillation are significantly influenced by these parameters. The results obtained in this study could enable the controlled self-oscillation of BZ gels system. This has several potential applications such as controlled drug delivery, miniature peristaltic pumps and microactuators. | WANG PengFei1, ZHOU JinXiong1, LI MeiE2, XU Feng1,3 & LU TianJian1 1 Biomedical Engineering and Biomechanics Center, SV Laboratory, Xi’an Jiaotong University, Xi’an 710049, China 2 School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China 3 HST Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, 510660, USA | 2010 | Science China(Technological Sciences)2010，53，7： | 3 |
| 7 | Staging of hepatocellular carcinoma显示文摘Clinical staging systems for hepatocellular carcinoma (HCC) provide guides to patientassessment and therapeutic decision making. The most commonly used staging systems for HCCinternationally are the Okuda classification and the pathologic tumor node metastasis (TNM)classification. But each has its own limitations. New staging systems for HCC have recently been reportedfrom Italy, France, Spain and China. In this review, we evaluated the staging systems of HCC anddiscussed the natural history and prognosis of tumors of different stages. We believe that a reliable newstaging system of HCC patients will be established in the near future. | Peng Yan Lu-Nan Yan the Department of Surgery, Pittsburg Medical College of USA First People’s Hospital of Chengdu, Chengdu 610041, China Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，4： | 2 |
| 8 | Impulse strength of transformer insulation with nonstandard waveshapes显示文摘 | Venkatesan S Usa S | 2007 | IEEE Transactions on Power Delivery2007，22，4： | 1 |
| 9 | RNA and Protein Requirements for Eukaryotic Selenoprotein Synthesis显示文摘Selenium has been recognized as an essential nutrient in animals since the 1950s. Demonstration of the role of dietary selenium in protection from oxidative stress foIlowed in the early 1970s, and was largely attributed to its presence as an integral part of cellular glutathione peroxidase. However, the functions of this enzyme did not explain many of the other effects of selenium deficiency. The identification of other mammalian selenoproteins during the last few years has provided new insights into the functions of this trace nutrient. The discovery that type 1 deiodinase (D1) is a selenoenzyme, in addition to unveiling an essential role for selenium in thyroid hormone action, has had more far-reaching implications. Studies of this protein opened the door for investigation of the requirements for eukaryotic selenoprotein synthesis,and the features that distinguish this pathway from the corresponding prokaryotic pathway.Selenium is present in a number of prokaryotic and eukaryotic proteins in the form of the unusual amino acid, selenocysteine. Incorporation of selenocysteine into these proteins requires a novel translation step in which UGA specifies selenocysteine insertion. Since UGA codons are typically recognized as translation stop signals, an intriguing question is raised: How does a cell recognize and distinguish a UGA selenocysteine codon from a UGA stop codon? In this review, we will focus on what is known about selenocysteine incorporation in eukaryotes, briefly summarizing initial studies and discussing a few recent advances in our understanding of this unique 'recoding' | MARLA J. BERRY GLOVER W. MARTIN Ⅲ, AND SUSAN C. LOW(Thyroid Division, Department of Medicine, Brigham and Women’s Hospital Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115,USA) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 1 |
| 10 | The effect of relaxin treatment on skeletal muscle injuries显示文摘 | Negishi S Li Y Usas A | 2005 | Am J Sports Med2005，33，12： | 1 |
| 11 | Response of metal oxide arrester in gas-insulated substation and methods to improve its dynamic characteristics显示文摘 | Valsalal P Usa S Udayakumar K | 2012 | IET Science Measurement andTechnology2012，6，4： | 1 |
| 12 | Cartilage repair using bone morphogenetie protein 4 and muscle-derived stem cells显示文摘 | Kuroda R Usas A Kubo S | 2006 | Arthritis Rheum2006，54，2： | 1 |
| 13 | The effect of relaxin treatment on skcletal muscle injuries显示文摘 | Negishi S Li Y Usas A | 2005 | Am J Sports Med2005，33，12： | 1 |
| 14 | Modelling of metal oxide arrester for very fast transients显示文摘 | Valsalal P Usa S Udayakumar K | 2011 | IET Science Measurement and Technology2011，5，4： | 1 |
| 15 | Impulse strength of transformer insulation with nonstandard waveshapes显示文摘 | Venkatesan S Usa S | 2007 | IEEE Transactions on Power Delivery2007，22，4： | 1 |
| 16 | Importance of capacitance on metal oxide arrester block model for VFTO applications显示文摘 | Valsalal P Usa S Udayakumar K | 2011 | IEEE Transaction on Power Delfvery2011，26，2： | 1 |
| 17 | Modified disruptive effect method as a measure of insulation strength for non-standard lighting waveforms显示文摘 | Usa S Udayakumar K Jayashankar V | 2002 | IEEE Transactions on Power Delivery2002，17，2： | 1 |
| 18 | Screw configuration effects on corn starch expansion during extrusion显示文摘 | Sokhey A S Kollengode A N Hanna M A (Lincoln USA) | 1994 | Journal of Food Science1994，59，4： | 1 |
| 19 | Cartilage repair using bone morphogenetie protein 4 and muscle-derived stem cells显示文摘 | Kuroda R Usas A Kubo S | 2006 | Arthritis Rheum2006，54，2： | 1 |
| 20 | The effect of relaxin treatment on skeletal muscle injuries显示文摘 | NEGISHI S LI Y USAS A | 2005 | Am J Sports Med2005，33，12： | 1 |
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