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72篇 您的检索式：作者名="VALDIVIA H"

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	题名	作者	年代	出处	被引量
1	Arrhythmogenic mechanisms in ryanodine receptor channelopathies显示文摘Ryanodine receptors(Ry Rs) are the calcium release channels of sarcoplasmic reticulum(SR) that provide the majority of calcium ions(Ca2+) necessary to induce contraction of cardiac and skeletal muscle cells.In their intracellular environment,Ry R channels are regulated by a variety of cytosolic and luminal factors so that their output signal(Ca2+) induces finely-graded cell contraction without igniting cellular processes that may lead to aberrant electrical activity(ventricular arrhythmias) or cellular remodeling.The importance of Ry R dysfunction has been recently highlighted with the demonstration that point mutations in RYR2,the gene encoding for the cardiac isoform of the Ry R(Ry R2),are associated with catecholaminergic polymorphic ventricular tachycardia(CPVT),an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular tachycardia in individuals with an apparently normal heart.Here we summarize the state of the field in regards to the main arrhythmogenic mechanisms triggered by Ry R2 channels harboring mutations linked to CPVT.Most CPVT mutations characterized to date endow Ry R2 channels with a gain of function,resulting in hyperactive channels that release Ca2+ spontaneously,especially during diastole.The spontaneous Ca2+ release is extruded by the electrogenic Na+/Ca2+ exchanger,which depolarizes the external membrane(delayed afterdepolarization or DAD) and may trigger untimely action potentials.However,a rare set of CPVT mutations yield Ry R2 channels that are intrinsically hypo-active and hypo-responsive to stimuli,and it is unclear whether these channels release Ca2+ spontaneously during diastole.We discuss novel cellular mechanisms that appear more suitable to explain ventricular arrhythmias due to Ry R2 loss-of-function mutations.	ZHAO Yan-Ting VALDIVIA Carmen R. GURROLA Georgina B. HERNNDEZ Jonathan J. VALDIVIA Héctor H.	2015	Science China(Life Sciences)2015，58，1：	14
2	Sarcoplasmic reticulum Ca2+ and heart failure : roles of diastolic leak and Ca2+ transport显示文摘	BERS D M EISNER D A VALDIVIA H H	2003	Circ Res2003，93，6：	1
3	Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure 显示文摘	Gomez A M Valdivia H H Cheng H	1997	Science1997，276，5313：	1
4	CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors 显示文摘	CAMORS E VALDIVIA H H	2014	Front Pharmacol2014，5，：	1
5	Analysis and interpretation of da ta from real-time PCR trace detection methods using quantitation of GM soya as a model system显示文摘	Burns M J Valdivia H Harris N	2004	Analytical and Bioanalytial Chemistry2004，378，6：	1
6	Modelling the limit of detection in re al-time quantitative PCR显示文摘	Burns M J Valdivia H	2007	Eur Food Res Technol2007，226，6：	1
7	Estimating powerenergy consumption in database servers 显示文摘	RODRIGUEZ-MARTINEZ M VALDIVIA H SEGUEL J	2011	Pro- cedia Computer Science2011，6，1：	1
8	Fluorescence - based isolatiou of bacterial genes expressed within host cells 显示文摘	Valdivia R H Falkow S	1997	Science1997，277，：	1
9	Applications for green fluorescent protein (GFP) in the study of hostpathogen interactions 显示文摘	Valdivia R H Alexander E H	1996	Gene1996，173，：	1
10	Direct binding of Verapamil to the ryanodine receptor channel of sarcoplasmic reticulum显示文摘	Valdivia H H Valdivia C M J Coronado R	1990	Biophys J1990，58，：	1
11	Emerging roles for lipid droplets in immunity and host-pathogen interactions 显示文摘	Saka H A Valdivia R	2012	Annu Rev Cell Dev Biol2012，28，：	1
12	Increased nitration of sarcoplasmic reticulum Ca^2+-ATPase in human heart failure 显示文摘	Lokuta A J Maertz N A Meethal S V Potter K T Kamp T J Valdivia H H	2005	Circulation2005，111，：	1
13	Virulence determinants in the ob- ligate intracellular pathogen Chlamydia traehomatis revealed by for'ward genetic approaches显示文摘	Nguyen B D Valdivia R H	2012	Proc Natl Acad Sci USA2012，109，4：	1
14	FACS-optimized mu- tants of the green fluorescent protein(GFP) 显示文摘	Cormaek B P Valdivia R H Falkows	1996	Gene1996，173，：	1
15	Detective excitation-contraction coupling in experimental heart failure 显示文摘	Gomez AM Valdivia HH Cheng H	1997	Science1997，276，：	1
16	Detective excitation- contraction coupling in experimental cardiac hypertrophy and heart failure显示文摘	G6mez AM Valdivia HH Cheng H et oi	1997	Science1997，276，5313：	1
17	Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions显示文摘	Valdivia R H Hromockyj A E Monack D	1996	Gene1996，173，1：	1
18	FACS-optimized Mutants of the Green Fluorescent Protein (GFP)显示文摘	Cormack B P Valdivia R H Falkow S	1996	Gene1996，173，1：	1
19	Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi显示文摘	Fernandez- Valdivia R Takeuchi H Samarghandi A	2011	Development2011，138，10：	1
20	Applications forgreen fluorescent protein in the study of host-pathogen interactions显示文摘	Valdivia R H Hromockyj A E Monack D	1996	Gene1996，173，：	1

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