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| 1 | Residents' Perceptions of Community Tourism Impacts 显示文摘 | ANDERECK K L VALENTINE K M KNOPF R C | 2005 | Annals of Tourism Research2005，32，4： | 1 |
| 2 | Identifi-cation of novel methane-,ethane-,and propane-oxidizing bacte-ria at marine hydrocarbon seeps by stable isotope probing显示文摘 | REDMOND M C VALENTINE D L SESSIONS A L | 2010 | Applied and Environmental Microbiology2010，76，19： | 1 |
| 3 | Natural gas and temperature structured a microbial community response to the Deepwater Horizon oil spill显示文摘 | Molly C Redmond David L Valentine | 2012 | PNAS2012，109，20： | 1 |
| 4 | Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells显示文摘 | Hodges-Gallagher L Valentine C Bader S | 2008 | Breast Cancer Res Treat2008，109，2： | 1 |
| 5 | A persistent oxygen anomaly reveals the fate of spilled methane in the deep Gulf of Mexico显示文摘 | J D Kessler D L Valentine M C Redmond | 2011 | Science2011，331，6015： | 1 |
| 6 | Chemical and microbiological assessment of pendimethalin-contaminated soil after treatment with Fenton's reagent显示文摘 | Miller C M Valentine R L Roehl M E | 1996 | Water Research1996，30，11： | 1 |
| 7 | Character- ization of elemental and structural composition of corro- sion scales and deposits formed in drinking water distri- bution systems 显示文摘 | Peng C Y Korshin G V Valentine R L | 2010 | Water Res2010，44，15： | 1 |
| 8 | Hydrogenproduction by Methanogens under Low-hydrogen Conditions显示文摘 | VALENTINE D L BLANTON D C REHNR W S | 2000 | Arch Microbiology2000，174，6： | 1 |
| 9 | Fate of Dispersants Associated with the Deepwater Hori- zon Oil Spill显示文摘 | Kujawinski E B Kido Soule M C Valentine D L | 2011 | Environmental Science & Technology2011，45，4： | 1 |
| 10 | Fate of Dis- persants Associated with the Deepwater Horizon Oil Spill显示文摘 | Kujawinski E B Soule M C K Valentine D L | 2011 | Env- iron Sci Technol2011，45，4： | 1 |
| 11 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 12 | Acute and chronic toxicities of boric acid to Daphnia magna Straus显示文摘 | LEWIS M A VALENTINE L C | 1981 | Bulletin of Environmental Contamination and Toxicology1981，27，1： | 1 |
| 13 | Visible blood in the stool in a neonatal intensive care unit显示文摘 | Cordero L Giannone P J Valentine C J | 2011 | Journal of Neonatal-Perinatal Medicine2011，4，3： | 1 |
| 14 | Infrared fundamental bands of O^13C^17O isotopic variants of carbon dioxide显示文摘 | Teffo J L Claveau C Valentin A | 1998 | JQSRT1998，59，35： | 1 |
| 15 | Water column methane oxidation adjacent to an area of active hydrate dissociation,Eel River Basin显示文摘 | Valentine D L Blanton D C Reeburgh W S | 2001 | Geochimica et Cosmochimica Acta2001，65，16： | 1 |
| 16 | Water column methane oxidation adjacent to an area of active hydrate dissociation, Eel River Basin 显示文摘 | Valentine D L Blanton D C Reeburgh W S | 2001 | Geochimca et Cosmochinwa Acta2001，65，： | 1 |
| 17 | Iron oxide surface catalyzed oxidation of quinolone by hydrogen peroxide显示文摘 | Valentine R L Wang H C A | 1998 | J Environ Eng1998，25，： | 1 |
| 18 | Iron oxide surface catalyzed oxidation of quinoline by hydrogen peroxide显示文摘 | Richard L Valentine H C Ann Wang | 1998 | Journal of Environmental Engineering1998，124，1： | 1 |
| 19 | 显示文摘 | Anderecka K L Valentine K M Knopf R C Vogta C A (2005) | 2005 | Annals of Tourism Research2005，，： | 1 |
| 20 | Nutritional management of the breastfeeding dyad显示文摘 | Valentine C J Wagner C L | 2013 | Pediatr Clin North Am2013，60，1： | 1 |
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