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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells显示文摘BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed recently.Bearing in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering constructs.AIM To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and OBs.METHODS ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral matrix.At 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 wk.RESULTS The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after implantation.BC had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and BPEO.Endothelial-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and BPEO.BPEO had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined constructs.Except Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in vivo incubation that induced late onset of Spp1 expression and pronounced osteocalcin immunoexpression at 2 and 8 wk.Tissue regression was noticed in BPEO constructs after 8 wk.CONCLUSION Ectopically implanted BPEO constructs had a favorable impact on vascularization and osteogenesis,but tissue regression imposed the need for discovering a more optimal EC/OB ratio prior to considerations for clinical applications. | Jelena G Najdanović Vladimir J Cvetković Sanja T Stojanović MarijaĐVukelić-Nikolić Jelena MŽivković Stevo J Najman | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 4 | Distance-Based outliers: Algorithms and Applications 显示文摘 | Edwin M Knorr Raymond T Ng and Vladimir Tucakov | 2000 | The VLDB Journal2000，8，3： | 2 |
| 5 | Distance-based Outliers:Algorithms and Applications显示文摘 | Edwin M K Raymond T N Vladimir Tucakov | 2000 | VLDB Journal2000，324，8： | 1 |
| 6 | Sin- gle-mass 6-DOF isotropic accelerometer with segmented PSD sen- sots显示文摘 | Chapsky Vladimir Portman Vladimir T Sandier Ben-Zion | 2007 | Sensors and Actuators A2007，135，： | 1 |
| 7 | A comprehensive urinary metabolomie approach for identifying kidney cancer显示文摘 | VLADIMIR T OLIVER F | 2007 | Anal Biochem2007，363，2： | 1 |
| 8 | Influence of ECAP routes on the microstructure and properties of pure Ti显示文摘 | Zhu Y T Alexandrov I V | 2001 | Materials Science and Engineering A2001，299，12： | 1 |
| 9 | PIAS proteins as roprossors of Oct4 function显示文摘 | Elena T Anna M Vladimir N | 2007 | J Mol Biol2007，374，： | 1 |
| 10 | Effects of Water Renewal Estimates on the Oyster Aquaculture Potential of an Inshore Area显示文摘 | GUYOUDET T VLADIMIR G K ROY S | 2005 | Journal of Marine Systems2005，58，： | 1 |
| 11 | Isolation of antigens and antibodies by affinity chromato- graphy 显示文摘 | Vladimir I Muronetz Korpela T | 2003 | Journal of Chromatography B2003，790，： | 1 |
| 12 | Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes 显示文摘 | ALEXANDER L K KAZUO M VLADIMIR P T | 1990 | FEBS Lett1990，268，1： | 1 |
| 13 | Dichloro-diphenytrichloroethane (DDT) : ubiquity, persistence, and risks 显示文摘 | VLADIMIR T VALERY R LORENZO T | 2002 | Research Review2002，110，2： | 1 |
| 14 | Metabolic effects of keto acid,amino acid supplementation in patients with chronic renal insrfficiency显示文摘 | Vladimir T Otto S Milo V | 2001 | The middle European journal of medicine2001，113，1718： | 1 |
| 15 | The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary n-telopeptide of type I collagen bone turnover marker显示文摘 | Golombick T Terrence H D Vladimir B | 2009 | Clin Cancer Res2009，15，18： | 1 |
| 16 | Mechanisms for the interactions between acidic oils and surfactant - enhanced alkaline solutions 显示文摘 | Youssef T Vladimir H | 1996 | Journal of Colloid and Interface science1996，177，： | 1 |
| 17 | Biomedical potential of the reactive oxygen species generation and quenching by fullerenes ( C60 ) 显示文摘 | ZORAN M VLADIMIR T | 2008 | Biomaterials2008，29，26： | 1 |
| 18 | Effect of telmisaartan on blood pressure control and kidney function in hypertensive, proteinuric patients with chronic kidney disease 显示文摘 | Romana R Vladimir T Miroslav M | 2005 | Blood Pressure Monitoring2005，10，4： | 1 |
| 19 | Single- Mass 6-DOF Isollpic Aecelerometer wilh Segmented PSD Sensors 显示文摘 | Vladimir Chapsky Vladimir T Pmlman Ben-Zion Sandier | 2007 | Sensot and Actuators2007，135，： | 1 |
| 20 | Organ printing:computer-aided jet-based 3D tissue engineering显示文摘 | VLADIMIR M THOMAS B THOMAS T | 2003 | Trends Biotechnol2003，21，4： | 1 |
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