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| 1 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 2 | Transanal hybrid colon resection: from laparoscopy to NOTES显示文摘 | Karl-Hermann Fuchs Wolfram Breithaupt Gabor Varga Thomas Schulz Alexander Reinisch Nenad Josipovic | 2013 | Surgical Endoscopy2013，，3： | 3 |
| 3 | Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs显示文摘Cyclooxygenase-2 (COX-2 ) 在 hypoxic-ischemic encephalopathy 的致病有一个确定的角色(催促) 。在这研究,我们寻求了决定 COX-2 是否被窒息在新生的猪导致,并且 neuronal COX-2 层次是否被 H 2 处理影响。小猪受到窒息或更多的任何一个 8 min 严重窒息的 20 min 由 H 2 处理(为 4 h 包含 2.1% H 2 的吸入的房间空气) 列在后面。COX-2 immunohistochemistry 从熬过小猪在大脑样品上被执行在窒息以后的 24 h。COX-2-immunopositive 神经原的百分比被决定在外皮并且 subcortical 区域。仅仅在小猪与更严重催促,我们在顶骨和枕骨的 cortices 以内并且在 CA3 海马趾的子字段在 neuronal COX-2 表示观察了重要、区域特定的增加。H 2 处理实质上在 COX-2-immunopositive 神经原阻止了增加。在顶骨外皮, COX-2 正式就职的变细与减少的 8-hydroxy-2-deoxyguanozine immunoreactivity 被联系并且保留了 microglial ramifcation 索引,它分别地是氧化应力和 neuroinfiammation 的标记。这研究第一次证明窒息在一头小猪提高 neuronal COX-2 表示催促模型。Neuronal COX-2 正式就职可以在大脑损害前进起区域特定的作用在期间催促开发,并且这回答的抑制可以贡献 H 2 处理的 antioxidant/anti-infiammatory neuroprotective 效果。 | Viktoria VARGA Janos NEMETH Orsolya OLAH Valeria TOTH-SZUKI Viktoria KOVACS Gabor REMZSO Ferenc DOMOKI | 2018 | Acta Pharmacologica Sinica2018，39，8： | 1 |
| 4 | Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery?显示文摘BACKGROUND The clinical presentation of gastroesophageal reflux disease(GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders.AIM To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux surgery.METHODS In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying for the indication of laparoscopic antireflux surgery, were investigated prospectively regarding their symptomatic spectrum in order to identify GERD and associated somatoform disorders. Assessment of symptoms was performed by an instrument for the evaluation of somatoform disorders[Somatoform Symptom Index(SSI) > 17]. Quality of life was evaluated by Gastrointestinal Quality of Life Index(GIQLI).RESULTS In 123 patients an indication for laparoscopic antireflux surgery was established and in 43 patients further medical therapy was suggested. The portion of somatoform tendencies in the total patient population was 20.48%(34 patients).Patients with a positive SSI had a preoperative GIQLI of 77(32-111). Patients with a normal SSI had a GIQLI of 105(29-140)(P < 0.0001). In patients with GERD the quality of life could be normalized from preoperative reduced values of GIQLI102(47-140) to postoperative values of 117(44-144). In patients with GERD and somatoform disorders, the GIQLI was improved from preoperative GIQLI 75(47-111) to postoperative 95(44-122)(P < 0.0043).CONCLUSION Patients with GERD and associated somatoform disorders have significantly worse levels of quality of life. The latter patients can also benefit from laparoscopic fundoplication, however they will not reach a normal level. | Hans Friedrich Fuchs Benjamin Babic Karl-Hermann Fuchs Wolfram Breithaupt Gabor Varga Frauke Musial | 2019 | World Journal of Gastroenterology2019，25，3： | 1 |
| 5 | The role of neoadjuvanttherapy in the treatment of locally advanced squamous cell cancer ofthe cervical oesophagus显示文摘 | Papp Andras Cseke Laszlo Varga Gabor | 2012 | Magyar sebeszet2012，65，5： | 1 |
| 6 | Common and conflicting objectives and practices of herders and conservation managers:the need for a conservation herder显示文摘The mutual dependence of extensive land-use and conservation management has become appar-ent in Europe in the last 20-30 yr.Extensive land-use often survives in protected areas only,in the form of conservation management.Knowledge of extensive herding and that of conservation management are parts of two knowledge systems(traditional and scientific)which often leads to conflicts between locals and con-servationists.We studied two herding/conservation systems(salt steppes and wood-pastures),and devel-oped an inventory on the common/similar and conflicting/different objectives and pasture management practices of herders and conservationists.Data were collected by participatory knowledge co-production in teamwork of the co-authors(herders,conservation managers,and scientists).Data were analyzed and discussed in teamwork too.Herders and conservationists identified 23 objectives and 29 management prac-tices.We found a number of common interests with respect to herding,the ideal state of pastures,legal provisions,and communication.Conflict resolution recommendations(e.g.,on time and place of grazing,pasture improvements)were also developed.We argue that by co-production of knowledge,and establish-ment of a herder“school”the mitigation of the existing conflicts would be more effective.Our conclusion is that a new profession is needed:that of the conservation herder.The conservation herder shall be an indi-vidual knowledgeable about herding and pasture management,trained in conservation and ecology,able to design management experiments,and develop novel but tradition-based management practices.As such,he/she could facilitate adaptation of extensive herding in the changing socio-economic environment. | Zsolt Molnar Jozsef Kis Csaba Vadasz Laszlo Papp Istvan Sandor Sandor Beres Gabor Sinka Anna Varga | 2016 | Ecosystem Health and Sustainability2016，2，4： | 0 |
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