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| 1 | Non-alcoholic fatty liver disease: What the clinician needs to know显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most frequent cause of liver disease in the Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic. Though highly frequent, only about one fifth of affected subjects are at risk of developing the progressive form of the disease, non-alcoholic steatohepatitis with fibrosis. Even in the latter, liver disease is slowly progressive, though, since it is so prevalent, it is already the third cause of liver transplantation in the United States, and it is predicted to get to the top of the ranking in few years. Of relevance, fatty liver is also associated with increased overall mortality and particularly increased cardiovascular mortality. The literature and amount of published papers on NAFLD is increasing as fast as its prevalence, which makes it difficult to keep updated in this topic. This review aims to summarize the latest knowledge on NAFLD, in order to help clinicians understanding its pathogenesis and advances on diagnosis and treatment. | Mariana Verdelho Machado Helena Cortez-Pinto | 2014 | World Journal of Gastroenterology2014，20，36： | 45 |
| 2 | Iron homeostasis and H63D mutations in alcoholics with and without liver disease显示文摘AIM: To evaluate the prevalence of HFE gene mutation and indices of disturbed iron homeostasis in alcoholics with and without liver disease.METHODS: One hundred and fifty-three heavy drinkers (defined as alcohol consumption > 80 g/d for at least 5 years) were included in the study. These comprised 78 patients with liver disease [liver disease alcoholics (LDA)] in whom the presence of liver disease was confirmed by liver biopsy or clinical evidence of hepatic decompensation, and 75 subjects with no evidence of liver disease, determined by normal liver tests on two occasions [non-liver disease alcoholics (NLDA)], were consecutively enrolled. Serum markers of iron status and HFE C282Y and H63D mutations were determined. HFE genotyping was compared with data obtained in healthy blood donors from the same geographical area.RESULTS: Gender ratio was similar in both study groups. LDA patients were older than NLDA patients (52 ± 10 years vs 48 ± 11 years, P = 0.03). One third and one fi fth of the study population had serum transferrin saturation (TS) greater than 45% and 60% respectively. Serum iron levels were similar in both groups. However, LDA patients had higher TS (51 ± 27 vs 36 ± 13, P < 0.001) and ferritin levels (559 ± 607 ng/mL vs 159 ± 122 ng/mL, P < 0.001), and lower total iron binding capacity (TIBC) (241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001). The odds ratio for having liver disease with TS greater than 45% was 2.20 (95% confi dence interval (CI): 1.37-3.54). There was no difference in C282Y allelic frequency between the two groups. However, H63D was more frequent in LDA patients (0.25 vs 0.16, P = 0.03). LDA patients had a greater probability of carrying at least one HFE mutation than NLDA patients (49.5% vs 31.6%, P = 0.02). The odds ratio for LDA in patients with H63D mutation was 1.57 (95% CI: 1.02-2.40).CONCLUSION: The present study confirms the presence of iron overload in alcoholics, which was more severe in the subset of subjects with liver disease, in parallel with an increased frequency of H63D HFE mutation. | Mariana Verdelho Machado Paula Ravasco Alexandra Martins Maria Rosário Almeida Maria Ermelinda Camilo Helena Cortez-Pinto | 2009 | World Journal of Gastroenterology2009，15，1： | 3 |
| 3 | Depressive symptoms after stroke and relationship with dementia: A three-year follow-up study显示文摘 | A. Verdelho H. Hénon F. Lebert F. Pasquier D. Leys | 2004 | Neurology2004，，6： | 2 |
| 4 | An active power filter and unbalanced current compensator显示文摘 | Verdelho P Marques G D | 1997 | IEEE Transactions on Industrial Electronics1997，44，3： | 1 |
| 5 | An active power filter and unbalanced current compensator显示文摘 | Verdelho P Marques G D | 1997 | IEEE Transactions on Industrial Electronics1997，44，3： | 1 |
| 6 | Depressive symptoms afterstroke and relationship with dementia:A three-year follow-up study显示文摘 | Verdelho A Henon H Lebert F | 2004 | Neurology2004，62，6： | 1 |
| 7 | Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study显示文摘 | Verdelho A Henoll H Lebert F | 2004 | Neurology2004，62，6： | 1 |
| 8 | White matter changes and diabetes predict cognitive decline in the elderly:the LADIS study显示文摘 | Verdelho A Madureira S Moleiro C | 2010 | Neurology2010，75，2： | 1 |
| 9 | Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study显示文摘 | Verdelho A Madureira S Moleiro C | 2013 | J Neurol Neurosurg Psychiatry2013，84，11： | 1 |
| 10 | Depressive symptoms after stroke and relationship with dementia: a three year follow-up study显示文摘 | Verdelho A Henon H Lebert F | 2004 | Neurology2004，62，6： | 1 |
| 11 | Physical activity prevents progression for cognitive impairment and vascular dementia显示文摘 | Verdelho A Madureira S Ferro JM | 2012 | Stroke2012，43，12： | 1 |
| 12 | Depressive symptoms after stroke and relationship with dementia:A three-year follow-up study显示文摘 | Verdelho A Henon H Lebert F | | 0，，： | 1 |
| 13 | Depressive symptoms after stroke and relationship with dementia:A three-year follow-up study显示文摘 | Verdelho A Hénon H Lebert F | 2004 | Neurology2004，62，6： | 1 |
| 14 | DC voltage control and stability analysis of PWM voltage type prversible rectifiers显示文摘 | Pedro Verdelho Marques G D | 1998 | IEEE Trans on IE1998，45，2： | 1 |
| 15 | Develop- ment of a neuropsychological battery for the Leukoarai- osis and Disability in the Elderly Study (LADIS) : ex- perience and baseline data 显示文摘 | Madureira S Verdelho A Ferro J | 2006 | Neuroepidemiology2006，27，2： | 1 |
| 16 | A current control system based in αβ0 variables for a four-leg PWM voltage converter 显示文摘 | VERDELHO P MARQUES G D | 1998 | IEEE- IECON''98 conf1998，3，： | 1 |
| 17 | White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study显示文摘 | Verdelho A Madureira S Moleiro C | 2010 | Neurology2010，75，2： | 1 |
| 18 | Depressive symptoms after stroke and dementia: A three year follow up study 显示文摘 | Verdelho A Henon H Leben F | 2004 | Neurology2004，62，6： | 1 |
| 19 | Depressive symp- toms after stroke and relationship with dementia:A three-year fol- low-up study显示文摘 | VERDELHO A HENON H LEBERT F | 2004 | Neurology2004，62，6： | 1 |
| 20 | No need for a large belly to have NASH显示文摘 | Mariana Verdelho Machado Helena Cortez-Pinto | 2011 | Journal of Hepatology2011，，6： | 1 |
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