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| 1 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019,25,26: | 3 |
| 2 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013,,: | 2 |
| 3 | Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage 显示文摘 | Vicki W Thomas H | 2005 | Trends Pharmacol Sci2005,26,9: | 1 |
| 4 | Calcite (1014)surface in hu- mid environments显示文摘 | Jonas Baltrusaitis Vicki H Grassian | 2009 | Surface Science2009,603,: | 1 |
| 5 | A comparison of option prices under different pricing measures in a stochastic volatility model with correlation 显示文摘 | VICKY H DAVID H SAM H | 2005 | Review of Derivativatives Research2005,,8: | 1 |
| 6 | Trend in the prevalence, awareness, treatment, and control of hypertension in the adult US population: data from the health examination surveys, 1960 to 1991 显示文摘 | Vicki LB Jeffrey AC Millicent H | 1995 | Hypertension1995,26,: | 1 |
| 7 | A Comparison of Option Prices under Different Pricing Measures in A Stochastic Volatility Model With Correlation显示文摘 | VICKY H DAVID H SAM H | 2005 | Review of derivatives research2005,8,: | 1 |
| 8 | Body composition measurement: A review of hydrodensitometry,anthropometry, and impedance methods显示文摘 | David B Vicki M Rob H | 1998 | Nutr1998,14,3: | 1 |
| 9 | Context-specific inhibition of JNKs:overcoming the dilemma of protection and damage显示文摘 | Vicki W Thomas H | 2005 | Trends Pharmacol Sci2005,26,9: | 1 |
| 10 | Trends in the prevalence,awareness,treatment,and control of hypertension in the adult US population:data from the health examination surveys,1960 to 1991显示文摘 | Vicki LB Jeffrey AC Millicent H | 1995 | Hypertension1995,26,: | 1 |
| 11 | Context-specific inhibition of JNKs:overcoming the dilemma of protection and damage显示文摘 | Vicki W Thomas H | 2005 | Trends Pharmacol Sci2005,26,9: | 1 |
| 12 | Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial显示文摘 | John J Bissler J Christopher Kingswood El?bieta Radzikowska Bernard A Zonnenberg Michael Frost Elena Belousova Matthias Sauter Norio Nonomura Susanne Brakemeier Petrus J de Vries Vicky H Whittemore David Chen Tarek Sahmoud Gaurav Shah Jeremie Lincy David | 2013 | The Lancet . 2013 (9869)2013,,: | 1 |
| 13 | Trends in the prevalence ,awareness, treatment , and control of hyoertention in the adult US population: data from the health examination surveys, 1960to 1991显示文摘 | Vicki D LB Jeffrey D AC Millicent H | 1995 | Hypertention1995,26,: | 1 |
| 14 | Hepatitis C virus induces toll-like receptor 4 expression,leadingto enhanced production of beta interferon and interleukin-6显示文摘 | Keigo Machida Kevin T H Cheng Vicky M H Sung | 2006 | J Virol2006,80,2: | 1 |
| 15 | A preliminary study in usingvirtual reality to train dental student显示文摘 | Vicki R L Alice U Farhad H | 2007 | JDentEduc2007,68,3: | 1 |
| 16 | Genotypic variation for three physiological traits affecting drought tolerance in soybean显示文摘 | Vicki Hufstetler E Roger Boerma H Thomas E | 2007 | Crop Sei2007,47,: | 1 |
| 17 | Spreliminary study in using virtual reality to train dental student显示文摘 | Vicki RL Alice U Farhad H | | J Dent Educ0,68,3: | 1 |
| 18 | Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care显示文摘 | Julia HC Mike P Vicky H | 2001 | BMJ2001,323,: | 1 |
| 19 | Trends in the prevalence,awareness,treatment,and control of hypertension in the adult US population:data from the health examination surveys,1960 to 1991显示文摘 | Jeffrey AC Millicent H | 1995 | Hypertension1995,26,: | 1 |
| 20 | Sense of coherence and quality of life in women with and without irritable bowel syndrome显示文摘 | Sandra AM Vicky H Monica J | 2003 | Nurs Res2003,52,: | 1 |