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| 1 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 4 | Regional Features and Seasonality of Land–Atmosphere Coupling over Eastern China显示文摘Land-atmosphere coupling is a key process of the climate system, and various coupling mechanisms have been proposed before based on observational and numerical analyses. The impact of soil moisture(SM) on evapotranspiration(ET) and further surface temperature(ST) is an important aspect of such coupling. Using ERA-Interim data and CLM4.0 offline simulation results, this study further explores the relationships between SM/ST and ET to better understand the complex nature of the land-atmosphere coupling(i.e., spatial and seasonal variations) in eastern China, a typical monsoon area. It is found that two diagnostics of land-atmosphere coupling(i.e., SM-ET correlation and ST-ET correlation) are highly dependent on the climatology of SM and ST. By combining the SM-ET and ST-ET relationships, two 'hot spots' of land-atmosphere coupling over eastern China are identified: Southwest China and North China. In Southwest China, ST is relatively high throughout the year, but SM is lowest in spring, resulting in a strong coupling in spring. However, in North China, SM is relatively low throughout the year, but ST is highest in summer, which leads to the strongest coupling in summer. Our results emphasize the dependence of land-atmosphere coupling on the seasonal evolution of climatic conditions and have implications for future studies related to land surface feedbacks. | Chujie GAO Haishan CHEN Shanlei SUN Bei XU Victor ONGOMA Siguang ZHU Hedi MA Xing LI | 2018 | Advances in Atmospheric Sciences2018，35，6： | 5 |
| 5 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 6 | Iron oxide nanoparticle-based theranostics for cancer imaging and therapy显示文摘Theranostic 站台,与诊断、治疗学的功能被装备,是在癌症治疗的一条有希望的途径。从学习的各种各样的 nanotheranostics,氧化铁 nanoparticles 自从 IONP 有好 biocompatibility 和空间成像能力,有优点。这评论为癌症成像和治疗集中于基于 IONP 的 nanotheranostics。为 IONP nanotheranostics 的应用的最近的进步被总结,它包括基于 IONP 的诊断,磁性的回声成像(MRI ) ,多模式的成像,化疗,过高热的治疗,光力学的治疗,和基因交货。未来观点和挑战也被构画出因为 IONP 的潜在的发展在临床的使用基于 theranostics。 | Xiaoqing REN Hongwei CHEN Victor YANG Duxin SUN | 2014 | Frontiers of Chemical Science and Engineering2014，8，3： | 3 |
| 7 | Imaging pancreatobiliary ductal system with optical coherence tomography: A review显示文摘An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions. | Mohammad S Mahmud Gray R May Mohammad M Kamal Ahmed S Khwaja Carry Sun Alex Vitkin Victor XD Yang | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 2 |
| 8 | Structural characterization of coatomer in its cytosolic state显示文摘上衣蛋白质上的研究(COPI ) 我贡献了上衣蛋白质怎么产生泡开始细胞内部的运输的基本理解。COPI 建筑群的核心部件是 coatomer,它是需要从 cytosol 被招募到膜以便在膜弯曲并且货物排序工作的 multimeric 建筑群。clathrin 适配器上的以前的结构的研究发现了膜招募在在货物排序支持他们的角色导致一个大 conformational 变化。这里,追求否定污点的电子显微镜学结合了单个粒子的分析,和也表现的 CXMS (化学 cross-linking 结合了集体 spectrometry ) 为确认,我们重建了在它的可溶的形式的 coatomer 的结构。当与在它的膜界限形式的 coatomer 的以前阐明的结构相比我们不观察一个大 conformational 变化时。因此,结果揭开 COPI 对 clathrin 怎么覆盖的关键差别被膜招募调整。 | Shengliu Wang Yujia Zhai Xiaoyun Pang Tongxin Niu Yue-He Ding Meng-Qiu Dong Victor W. Hsu Zhe Sun Fei Sun | 2016 | Protein & Cell2016，7，8： | 2 |
| 9 | CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer显示文摘 | Kit W. Tam Wei Zhang Junichi Soh Victor Stastny Min Chen Han Sun Kelsie Thu Jonathan J. Rios Chenchen Yang Crystal N. Marconett Suhaida. A. Selamat Ite A. Laird-Offringa Ayumu Taguchi Samir Hanash David Shames Xiaotu Ma Michael Q. Zhang Wan L. Lam Adi Gaz | 2013 | Journal of Thoracic Oncology2013，，11： | 1 |
| 10 | Protection Against Lethal Multidrug-Resistant Bacterial Infections Using Macrophage Cell Therapy显示文摘Multidrug-resistant(MDR)bacterial infections exert a tremendous burden on the public health system throughout the developing and developedworld.Slowing development of novel antibiotic scaffolds,over-prescription of antibiotics,extensive agricultural antibiotic use,and the increasingly complex hospitalized patient populations undergoing treatment,all fuel the rise of highly MDR“superbugs.”Unfortunately,host-directed therapies to boost immune resistance to infection are not currently available for treatment of MDR pathogens.Hematopoietic cells are endowed with a variety ofmechanismsto control microbial invasion.Macrophages in particular have long been appreciated as potent antimicrobial immune cells equipped with several receptors that allow for rapid recognition,phagocytosis,and killing of pathogenic microbes,coupled to secretion of immunostimulatory cytokines to further orchestrate a robust multifaceted antibacterial immune response.To investigate the utility of macrophages as a cell therapy for MDR bacterial infections,we developed a therapeutically translatable process to generate,harvest,and cryopreserve monocyte-derived macrophages(ICONIMACTM).These cells effectively killed both Gram-positive and Gram-negative MDR pathogens in vitro,and conferred protection in vivo against experimental lethal peritonitis and lung infection.Our discoveries provide a proof-of-concept for a novel immunotherapeutic approach against MDR bacterial infections,urgently needed to supplement the diminishing antibiotic pipeline. | Robert Tacke Josh Sun Satoshi Uchiyama Anya Polovina Deborah G.Nguyen Victor Nizet | 2019 | Infectious Microbes & Diseases2019，1，2： | 1 |
| 11 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 12 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 13 | Matrix Stiffness-Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction显示文摘 | Huang Xiangwei Yang Naiheng Fiore Vincent F Barker Thomas H Sun Yi Morris Stephan W Ding Qiang Thannickal Victor J Zhou Yong | 2012 | EN2012，，3： | 1 |
| 14 | RecCac:Recommendation-Empowered Cooperative Edge Caching for Internet of Things显示文摘Edge caching is an emerging technology for supporting massive content access in mobile edge networks to address rapidly growing Internet of Things(IoT)services and content applications.However,the edge server is limited with the computation/storage capacity,which causes a low cache hit.Cooperative edge caching jointing neighbor edge servers is regarded as a promising technique to improve cache hit and reduce congestion of the networks.Further,recommender systems can provide personalized content services to meet user’s requirements in the entertainment-oriented mobile networks.Therefore,we investigate the issue of joint cooperative edge caching and recommender systems to achieve additional cache gains by the soft caching framework.To measure the cache profits,the optimization problem is formulated as a 0-1 Integer Linear Programming(ILP),which is NP-hard.Specifically,the method of processing content requests is defined as server actions,we determine the server actions to maximize the quality of experience(QoE).We propose a cachefriendly heuristic algorithm to solve it.Simulation results demonstrate that the proposed framework has superior performance in improving the QoE. | HAN Suning LI Xiuhua SUN Chuan WANG Xiaofei Victor C.M.LEUNG | 2021 | ZTE Communications2021，19，2： | 1 |
| 15 | Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial‐to‐mesenchymal transition显示文摘 | Paul Roepman Andreas Schlicker Josep Tabernero Ian Majewski Sun Tian Victor Moreno Mireille H Snel Christine M Chresta Robert Rosenberg Ulrich Nitsche Teresa Macarulla Gabriel Capella Ramon Salazar George Orphanides Lodewyk FA Wessels Rene Bernards Iris M | 2013 | Int. J. Cancer2013，，3： | 1 |
| 16 | Fractionation of red wine polyphenols by solid-phase extraction and liquid chromatography显示文摘 | Baoshan Sun M. Concei??o Leandro Victor de Freitas M. Isabel Spranger | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 17 | Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial显示文摘 | Yi-Long Wu Jin Soo Lee Sumitra Thongprasert Chong-Jen Yu Li Zhang Guia Ladrera Vichien Srimuninnimit Virote Sriuranpong Jennifer Sandoval-Tan Yunzhong Zhu Meilin Liao Caicun Zhou Hongming Pan Victor Lee Yuh-Min Chen Yan Sun Benjamin Margono Fatima Fuerte | 2013 | Lancet Oncology2013，，8： | 1 |
| 18 | High-resolution imaging of microvasculature in human skin in-viva with optical coherence tomography显示文摘 | Gangjun Liu Wangcun Jia Victor Sun | 2012 | Opt Express2012，20，7： | 1 |
| 19 | Prepa- ration of polycyclodextrin hollow spheres by tem- plating gold nanoparticles显示文摘 | Sun Li Crooks Richard M Chechik Victor | 2001 | Chemical Communi- cations2001，，4： | 1 |
| 20 | Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization显示文摘 | Sheryl T. Smith Priyankara Wickramasinghe Andrew Olson Dmitri Loukinov Lan Lin Joy Deng Yanping Xiong John Rux Ravi Sachidanandam Hao Sun Victor Lobanenkov Jumin Zhou | 2009 | Developmental Biology2009，，2： | 1 |
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