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| 1 | PACAP对豚鼠离体胆囊平滑肌的作用显示文摘目的探讨 VIP 族神经肽PACAP 对胆囊运动的影响。方法将豚鼠胆囊制备成1.2mm×10mm 的平滑肌条标本4条,固定在组织浴槽中,并连接等张换能器。以 pH7.4的 Krebs-Ringer缓冲液灌流,温度37℃,并通与95% O_2和5% CO_2。胆囊条对神经肽的效应,用ACh 作标准化处理。结果 VIP 对胆囊条有浓度依赖性的舒张作用;PACAP 则呈现出浓度依赖性收缩反应,PACAP38的作用弱于 PACAP27。结论 PACAP 和 VIP 在对离体胆囊运动的作用方面,呈相反的效应。 | 魏睦新 Satoru Naruse 尾崎毅 轩原清史 安藤英治 Victor Wray | 1996 | 新消化病学杂志1996，4，5： | 3 |
| 2 | Possible key residues that determine left gastric artery blood flow response to PACAP in dogs显示文摘AIM:To determine the effect of pituitary adenylate cy-clase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes. METHODS: Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. Whenpeptides were infused intravenously, the blood flow was measured.RESULTS: [Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA ? ow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses. CONCLUSION: NH2 terminus is more important to biological activity of peptides and specifi c receptor recognition than COOH-terminus. | Mu-Xin Wei Ping Hu Ping Wang Satoru Naruse Kiyoshi Nokihara Victor Wray Tsuyoshi Ozaki | 2010 | World Journal of Gastroenterology2010，16，38： | 2 |
| 3 | Initial reactions in the biodegradation of 1-chloro-4-nitrobenzene by a newly isolated bacterium,strain LW1显示文摘 | Eleftheria Katsivela Victor Wray Dietmar H Pieper | 1999 | Apply Environ Microbiol1999，65，4： | 1 |
| 4 | Marine biosurfactants. IV. Production, characterization and biosynthesis of an anionic glucose lipid from the marine bacterial strain MM1显示文摘 | Angelina Passeri Michael Schmidt Thomas Haffner Victor Wray Siegmund Lang Fritz Wagner | 1992 | Applied Microbiology and Biotechnology1992，，3： | 1 |
| 5 | Characterization of a new lipoptetide surfactant produced by thermotolerant and halotolerant surface bacillus licheniform is BASSO 显示文摘 | Michail M Yakimov kenneth N Timms victor Wray | 1995 | Appl Environ Microbiol1995，61，5： | 1 |
| 6 | trans-coniferyl alcohol 4-0-sulfate andflavonoid sulfates from some Tamarix species显示文摘 | Tomas-Barberan FranciscoA Iniesta-Sanmartin Esther Ferreres Federico Tomas-LorenteFrancisee Trowitzsch-Kiehast Wolfram Wray Victor | 1990 | Phytochemistry1990，29，9： | 1 |
| 7 | A Cyanogenic glycoside from canthium schimperianum 显示文摘 | Brunhilde Schwarz Victor Wray Peeter Prokscht | 1996 | Phytrochemistry1996，42，3： | 1 |
| 8 | Phenylpropanoid glycosides, a furanone glucoside and geniposidic acid from members of the rubiaceae 显示文摘 | Adolf Nahrsted Jurgen Rockenbach Victor Wray | 1995 | Phytochemistry1995，39，2： | 1 |
| 9 | Cyanogenic glycosides from psydrax and oxyanthus species 显示文摘 | Jurgen Rockenbach Adolf Nahrstedt Victor Wray | 1992 | Phytochemistry1992，31，2： | 1 |
| 10 | Monitoring Key Reactions in Degradation of Chloroaromatics by ln Situ 1H Nuclear Magnetic Resonance: Solution Structures of Metabolites Formed from cis Dienelactone显示文摘 | Dietmar H Pieper Bernardo Gonzalez Victor Wray | 2002 | J Bacteriol2002，184，： | 1 |
| 11 | Formation and occurrence of dopamine-derived betacyanins显示文摘 | Naoko Kobayashi Jurgen Schmidt Victor Wray | 2001 | Phytochemistry2001，56，： | 1 |
| 12 | Betalains from christmas cams显示文摘 | Naoko Kobayashi Jurgen Schmidt Victor Wray | 2000 | Phytochemistry2000，54，： | 1 |
| 13 | Insecticidal constituents from rhizomes of zingiber cassumunar and Kaempferia rotunda 显示文摘 | Bambang W Nugroho Brunhilde Schwarz Victor Wray | 1996 | Phytochemistry1996，41，1： | 1 |
| 14 | Characterization of a new lipopeptide surfactant produced by thermotolerant and halotolerant subsurface Bncillus licheniformis BSASO 显示文摘 | MICHAIL M YAKIMOV KENNETH N TIMMIS VICTOR WRAY | 1995 | Appl Environ Microbiol1995，61，5： | 1 |
| 15 | Polyketides from the mangrove-derived endophytic fungus Acremonium strictum显示文摘 | Lena Hammerschmidt Abdessamad Debbab Tu Duong Ngoc Victor Wray Catalina Perèz Hemphil WenHan Lin Heike Broetz-Oesterhelt Matthias U. Kassack Peter Proksch Amal H. Aly | 2014 | Tetrahedron Letters2014，，： | 1 |
| 16 | PACAP结构活性相关性的研究显示文摘目的运用合成的 VIP/PACAP 相关肽,在离体豚鼠胆囊探讨 PACAP 的结构与生物活性的相关性.方法用多品种同时氨基酸固相合成仪 Fmoc 法高效合成 VIP,PACAP 及其相关肽.用改良水平浴槽法测定比较各多肽对离体豚鼠胆囊的生物效应.结果 VIP 引起豚鼠胆囊平滑肌的舒张;与此相反,PACAP27则呈收缩效应,改变第4、第5和第24-26位氨基酸残基,对其生物效应没有明显影响.尽管[Leu^(13)]-PACAP27,是一个在α螺旋区域的变构体,但其收缩胆囊的活性并没有明显降低(P>0.05),而且较[Gly^8]-,[DAsp^8]-PACAP27和第21位的3个置换物更强.Des-[His^1]和[Ala^6]-PACAP27在10^(-7)mol/L 的浓度时未见生物活性,[Gly^8]-,[DAsp^8]-,[Phe^(21)]-和[Pro^(21)]-PACAP27在该浓度时收缩效应仅相当于 PACAP27的25%(P<0.05).结论在对豚鼠胆囊平滑肌的生物活性方面,PACAP27的 N 端(第1-8位)氨其酸残基较其他区域更为重要. | 魏睦新 成濑达 轩原清史 尾崎毅 安藤英治 Victor Wray | 1996 | World Journal of Gastroenterology1996，2，3： | 0 |
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