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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Safety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience显示文摘 | Audrey Coilly Bruno Roche Jér?me Dumortier Vincent Leroy Danielle Botta-Fridlund Sylvie Radenne Georges-Philippe Pageaux Si-Nafaa Si-Ahmed Olivier Guillaud Teresa Maria Antonini Stéphanie Ha?m-Boukobza Anne-Marie Roque-Afonso Didier Samuel Jean-Charles Du | 2014 | Journal of Hepatology2014，，1： | 2 |
| 3 | Sensitivity of de- pression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors 显示文摘 | Vincent MY Hussain RJ Zampi ME | 2013 | Brain Res2013，7，1525： | 1 |
| 4 | Childhood cancer and magnetic fields from high-voltage power lines in England and Wales:a case-control study显示文摘 | Kroll ME Swanson J Vincent TJ | 2010 | Br J Cancer2010，103，7： | 1 |
| 5 | Antibodies in myasthenia gravis and related disorders显示文摘 | Vincent A McConville J Farrugia ME | 2003 | Ann N Y Acad Sci2003，998，： | 1 |
| 6 | Seronegatire myasthenia gravis 显示文摘 | Vincent A McConville J Farrugia ME | 2004 | Semin Neurol2004，24，1： | 1 |
| 7 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 8 | Prospective evaluation of a new ultrathin one-plane bending videoendoscope for transnasal EGD: a comparative study on performance and tolerance显示文摘 | Jér?me Dumortier Claire Josso Sabine Roman Fabien Fumex Vincent Lepilliez Bénédicte Prost Muriel Olivier Guillaud Fabien Petit-Laurent Marie-George Lapalus Thierry Ponchon | 2007 | Gastrointestinal Endoscopy2007，，1： | 1 |
| 9 | A general transcrip- tion factor forms a stable complex with RNA polymerase B (11) 显示文摘 | Zheng XM Vincent M Jean ME | | Cell0，50，3： | 1 |
| 10 | Seronegative myasthenia gravis显示文摘 | Vincent A MeConville J Farrugia ME | 2004 | Semin Neurol2004，24，： | 1 |
| 11 | Seronegative myasthenia gravis显示文摘 | Vincent A McConville J Farrugia ME | 2004 | Semin Neurol2004，24，1： | 1 |
| 12 | Childhood cancer in relation to distance from high voltage power lines in England and Wales : a case-control study 显示文摘 | Draper G Vincent T Kroll ME | 2005 | BMJ2005，330，7503： | 1 |
| 13 | 癫痫持续状态的脑脊液和血液生物标志物显示文摘癫痫持续状态(Status epilepticus,SE)是一种由于终止癫痫发作的机制失效或导致异常长时间癫痫发作的机制启动而导致的状态,需要紧急应用抗癫痫药物。难治性SE需用麻醉药物,并可能导致脑损伤、分子和细胞改变(如炎症、神经元和星形胶质细胞损伤),可能导致神经系统的后遗症和癫痫的进一步发展。基于人口统计学、临床和脑电图(EEG)情况的预后评分是可用的,可以预测死亡风险,但对幸存者脑损伤的严重程度的评估较差。需要新的生物标志物以更准确地预测重症监护室住院患者的预后。在此,我们总结了SE患者和动物模型的研究结果。在脑脊液和血液中可以检测到特异的蛋白质标记物。最早被描述的神经元死亡标志物之一是神经元特异性烯醇化酶(Neuron-specific enolase,NSE)。SE后的炎症反应所导致的胶质增生可以通过增高的S100-β或一些细胞因子(高迁移率族蛋白1)被检测到。其他蛋白质,如颗粒蛋白前体(programanulin)可能反映了大脑对兴奋性毒性的适应所产生的神经保护机制。这些新的生物标志物旨在前瞻性地确定残障的严重程度和发展,以及SE患者随后的癫痫。我们通过评估每种生物标志物的脑特异性、在体液中的稳定性和对诸如溶血等外部干扰的敏感性来讨论其优缺点。最后,我们强调需要进一步开发和验证这些生物标志物,以便更好地评估严重的SE患者。 | Aurélie Hanin Virginie Lambrecq Jérôme Alexandre Denis 孙威(译) 慕洁(审) Vincent Navarro | 2021 | 癫痫杂志2021，7，4： | 1 |
| 14 | Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants显示文摘 | Mélanie Vallin Nathalie Sturm Géraldine Lamblin Olivier Guillaud Marie‐No?lle Hilleret Valérie Hervieu Juliette Joubert Armand Abergel Vincent Leroy Olivier Boillot Jér?me Dumortier Jean‐Yves Scoazec | 2013 | Clin Transplant2013，，3： | 1 |
| 15 | Antibodies in myasthenia gravis and related disorders显示文摘 | Vincent A McConville J Farrugia ME | 2003 | Ann N Y Acad Sci2003，998，： | 1 |
| 16 | Positivity rates and performances of immunochemical faecal occult blood tests at different cut-off levels within a colorectal cancer screening programme显示文摘 | Jean Faivre Vincent Dancourt Sylvain Manfredi Bernard Denis Gérard Durand Isabelle Gendre Jeanne Marie Bidan Christine Jard Romuald Levillain Sylvie Jung Jér?me Viguier Etienne Dorval | 2012 | Digestive and Liver Disease2012，，8： | 1 |
| 17 | Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis显示文摘 | Stegenga ME Vincent JL Vail GM | 2009 | Crit Care Med2009，20，10： | 1 |
| 18 | Characterization of quantitative chromosomal abnormalities in renal cell carcinomas by interphase four-color fluorescence in situ hybridization显示文摘 | Aline Ossard Receveur Je^ro^me Couturier Vincent Molinie' | 2005 | Cancer Genetics and Cytogenetics2005，158，： | 1 |
| 19 | Biopsy Specimens Obtained With Small-Caliber Endoscopes Have Comparable Diagnostic Performances Than Those Obtained With Conventional Endoscopes: A Prospective Study on 1335 Specimens显示文摘 | Thomas Walter Anne-Laure Chesnay Jér?me Dumortier Florence Mège-LeChevallier Valérie Hervieu Olivier Guillaud Marie-George Lapalus Vincent Lépilliez Fabien Fumex Thierry Ponchon Jean-Yves Scoazec | 2010 | Journal of Clinical Gastroenterology2010，，1： | 1 |
| 20 | Short-Term Outcome After Laparoscopic or Open Restorative Mesorectal Excision for Rectal Cancer: A Comparative Cohort Study显示文摘 | Bernard Lelong Thierry Bege Benjamin Esterni Jér?me Guiramand Olivier Turrini Vincent Moutardier Valérie Magnin Geneviève Monges Nicolas Pernoud Jean Louis Blache Marc Giovannini Jean Robert Delpero | 2007 | Diseases of the Colon & Rectum2007，，： | 1 |
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