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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 焊接参数对搅拌摩擦焊接AA2219-T87材料韧性、洋葱圆环的断裂行为的影响(英文)显示文摘与熔焊相比,搅拌摩擦焊可以更好地保持材料的韧性和塑性,提高焊接的抗裂稳定性。本研究旨在提高焊接接头的延性和强度。刀具廓形在保持延性、分析金属流动行为和确定断裂起始点等方面起着重要作用。分析了洋葱圆环不同区域的微观结构,得出了洋葱圆环强度与金属流型的关系。结果表明,洋葱圆环强化了焊缝熔核。肩部和锥形螺纹型线刀具具有优异的力学性能。显微硬度数据表明,断口经过热影响区和热机械影响区等低硬度区。扫描电镜图像显示了细长的晶粒和韧窝,证实了断裂为韧性断裂。 | Dinesh KUMAR R S MUTHUKUMARAN Vincent XAVIER T VENKATESWARAN D SIVAKUMAR | 2019 | Journal of Central South University2019，26，9： | 2 |
| 3 | Imaging of renovascular hypertension: respective values of renal scintigraphy,renal Doppler US,and MR angiography显示文摘 | GILLES S VINCENT L SOPHIE T | 2000 | Radiographics2000，20，5： | 2 |
| 4 | Neurosurgical outcomes after intracerebral hemorrhage:results of the factor seven for acute hemorrhagic stroke trial(FAST)显示文摘 | Steiner T Vincent C Morris S | 2011 | J Stroke Cerebrovasc Dis2011，20，4： | 1 |
| 5 | Influence of carbide coatings on the oxidation behavior of carbon fibers显示文摘 | Piquero T Vincent H Vincent C | 1995 | Carbon1995，33，1： | 1 |
| 6 | Minimizing interceptor size using neural networks for terminal guidance law synthesis显示文摘 | Gottell R G Vincent T L Sadati S H | 1996 | Journal of Guidance Control and Dynamics1996，19，3： | 1 |
| 7 | Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica显示文摘 | Saikali P Cayrol R Vincent T | 2009 | Autoimmun Rev2009，92，2： | 1 |
| 8 | Robust precoder adaptation for MIMO links with noisy limited feedback 显示文摘 | Wu T Y Vincent V | 2009 | IEEE Transactions on Information Theory2009，55，4： | 1 |
| 9 | Chondrocyte outgrowth into a gelatin scaffold in a single impact load model of damage/repair-effect of BMP-2显示文摘 | Frances M D Vincent T | 2007 | BMC Musculoskeletal Disorders2007，8，： | 1 |
| 10 | High-throughput solution processing of large-scale graphene显示文摘 | Vincent C T Matthew J A Yang Y | 2009 | Nature Nano technology2009，4，： | 1 |
| 11 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 12 | Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury 显示文摘 | Roya T Marie E R Vincent V | 2006 | Brain Res2006，1101，1： | 1 |
| 13 | Reduced lignin content and altered lignin composition in transgenic tobacco down -regulated in expression of L-phenylalanine ammonialyase or cinnamate 4-hydrelase显示文摘 | Vincent J H Sewal T Weiting N | 1997 | Plant Physiology1997，115，： | 1 |
| 14 | Evolution and control system design显示文摘 | VINCENT T L VINCENT T L S | 2000 | IEEE Control Systems Magazine2000，20，5： | 1 |
| 15 | Alzheimer's disease 2012 the great amyloid gamble显示文摘 | Vincent T Marchesi | 2012 | Am J Patho12012，180，5： | 1 |
| 16 | Using vanishing points for camera calibratian显示文摘 | Bruno C Vincent T | 1990 | Computer Vision1990，4，2： | 1 |
| 17 | High glucose and insulin promote O-GleNAe modification of proteins, including alpha-tubulin 显示文摘 | Walgren J L Vincent T S Schey K L et ol | 2003 | Am J Physiol Endoerinol Metab2003，284，2： | 1 |
| 18 | Influence of fiber orientation and specimen end condition on axial compressive behavior of FRP-confined concrete显示文摘 | Vincent T Ozbakkaloglu T | 2013 | Construction and Building Materials2013，47，： | 1 |
| 19 | Effector functions of antiaquaporin-4 autoantibodies in neuromyelitis optica显示文摘 | Cayrol R Saikali P Vincent T | 2009 | Ann N Y Acad Sci2009，1173，： | 1 |
| 20 | 显示文摘 | Vincent T Jourdan M Sy MS | 2001 | J Biol Chem2001，276，14： | 1 |
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