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| 1 | Risk factors for clinically significant macular edema in a multi-ethnics population with type 2 diabetes显示文摘·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student's t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. ·RESULTS:Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were significantly higher in the CSME group (P <0.05). The hemoglobin, packed cell volume were significantly lower in the CSME group (P <0.05). There was no significant difference for serum HDL, TG, BMI, systolic and diastolic BP. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c had significantly high odds of developing CSME. ·CONCLUSION:HbA1c and total cholesterol are the two most important risk factors associated with CSME in patients with NPDR. | Ong Ming Jew Mohammadreza Peyman Subrayan Visvaraja | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 7 |
| 2 | 皮质类固醇治疗外伤性视神经病变的四天关键时期显示文摘目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效。
方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料。1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量。记录从损伤开始到治疗开始的时间。视力变化是本研究结果的主要功能评价指标。在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA)。
结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例。引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%)。所有患者都表现有相对传入性瞳孔障碍。在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12)。在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步。
结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用。静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果。但还需要有更多的研究来为我们提供有明显统计学意义的数据。 | Soon Lek Yap Angeline Diong Ching Nga Nadir Ali Mohamed Ali Visvaraja Subrayan | 2008 | 国际眼科杂志2008，8，3： | 6 |
| 3 | 玻璃体内注射曲安奈德治疗继发于IRVAN的黄斑水肿(英文)显示文摘目的:报告玻璃体内注射曲安奈德对特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎(IRVAN)所致的黄斑水肿的治疗效果。方法:病例报告。结果:患者诊断为特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎导致的伴有视力丧失的继发性黄斑水肿。玻璃体内注射曲安奈德后黄斑水肿减轻,视力显著改善。结论:以前的报告建议采取全视网膜光凝,玻璃体切除术及全身和眼部类固醇治疗。对于继发于IRVAN的黄斑水肿和血管炎,玻璃体内注射曲安奈德是一种安全有效的治疗方法。 | Terrence Kwong-Weng Soong Visvaraja Subrayan Choo May May | 2010 | 国际眼科杂志2010，10，11： | 4 |
| 4 | 黄斑色素光学密度、中央黄斑厚度与体重指数的关系(英文)显示文摘目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用SD Cirrus OCT测量中央黄斑厚度。记录所有眼MPOD和OCT信息。使用Microsoft~?Excel,SPSS和R进行数据分析。结果:MPOD和中央黄斑厚度之间呈明显正相关(r=0.42,P<0.01)。同时,MPOD和BMI之间呈明显负相关(r=-0.23,P<0.01)。结论:研究得出,MPOD和中央黄斑厚度之间呈明显正相关。还需要进一步研究中央凹的详细结构及其与MPOD的关系。研究发现了MPOD与BMI之间呈明显正相关,且得出BMI的降低可能会增加黄斑色素的密度,这有助于预防年龄相关性黄斑变性(ARMD)。 | Lee Hong Nien Fazliana Ismail Rafidah Sudarno Angela Loo Voon Pei Visvaraja Subrayan | 2019 | 国际眼科杂志2019，19，5： | 3 |
| 5 | 玻璃体切割术联合人工晶状体巩膜固定术治疗眼外伤的疗效(英文)显示文摘目的:探讨玻璃体切割术(pars plana vitrectomy,PPV)联合人工晶状体(intraocular lens,IOL)巩膜固定术治疗眼外伤的疗效。方法:系列病例回顾性分析。将马来西亚大学医学中心接受PPV联合IOL巩膜固定术的8例连续性病例纳入研究,其中1例患者双眼均受伤,共有9眼。对现阶段视力,手术技巧,并发症及术后疗效进行分析。结果:9眼中有8眼(89%)视力提高。术后主要并发症是眼压升高,无缝线破裂。结论:PPV联合IOL巩膜固定术对有眼外伤病史的患者有非常好的疗效。 | Angela V PLoo Sujaya Singh Mohammadreza Peyman Visvaraja Subrayan | 2012 | 国际眼科杂志2012，12，6： | 2 |
| 6 | Changes in anterior chamber depth and intraocular pressure after phacoemulsification in eyes with occludable angles显示文摘 | Hoy Choong Shin Visvaraja Subrayan Iqbal Tajunisah | 2010 | Journal of Cataract & Refractive Surgery2010，，8： | 1 |
| 7 | Central Corneal Thickness Measurements With Different Imaging Devices and Ultrasound Pachymetry显示文摘 | Lai-Yong Tai Keat-Ween Khaw Choung-Min Ng Visvaraja Subrayan | 2013 | Cornea2013，，6： | 1 |
| 8 | 免疫功能正常患者鼻眶部毛霉菌病的研究(英文)显示文摘报告1例免疫功能正常患者鼻眶部毛霉菌病非典型病例,并对该病例进行相关文献回顾。患者,男,17岁,免疫功能正常,左眼2mo缓慢进行性疼痛肿胀。行组织活检,病理学诊断为毛霉菌病。采用综合疗法,包括筛窦及上颌窦侵入性内窥镜切除和清创、左眼眶内容物刮除术、静脉注射两性霉素B和眶内两性霉素B冲洗,成功根除真菌感染。该病例说明,鼻眶部毛霉菌病可发生在年轻健康的个体身上。早期诊断,积极的药物和手术治疗对成功地治疗这种罕见的具有潜在致命性的疾病是至关重要的。 | Keat Ween Khaw Amir bin Samsudin Zurina ZA Mimiwati binti Zahari Visvaraja Subrayan | 2012 | 国际眼科杂志2012，12，4： | 0 |
| 9 | Prolonged conjunctivitis mimicking nodular episcleritis as a manifestation of granulomatosis with polyangiitis-a case report显示文摘Red eye is common in our daily practice.It ranges from non-inflammatory to inflammatory causes.An extended course of disease should prompt suspicion and the possibility of diagnosis revision.A prolonged conjunctivitis mimicking nodular episcleritis can be presented as a manifestation of granulomatosis with polyangiitis(GPA).A 57-year-old woman complained of eye redness and tearing for two weeks which partially resolved with antibiotics.She was subsequently commenced on topical and oral non-steroidal anti-inflammatory drugs(NSAIDs)and topical anti-allergic.However,in the following reviews she developed cornea thinning and her systemic examination revealed an injected uvula with absence of upper respiratory tract infection.She was investigated for connective tissue disease and found to have raised anti-inflammatory markers and her antinuclear antibody and C-ANCA tests were positive.She was diagnosed with GPA.Her conditions improved followed by the commencement of topical corticosteroid with high dose of systemic corticosteroid,which followed by a tapering regime with oral corticosteroid.Although red eye is common,it is associated with a variety of diseases.GPA manifestation can be as subtle as a red eye.Any prolonged partially treated red eye should prompt suspicion of a more sinister cause.Sensitive detection of other subtle systemic signs is very important. | Hong Nien Lee Visvaraja Subrayan | 2022 | Annals of Eye Science2022，，1： | 0 |
| 10 | 疑似自然消退型视网膜母细胞瘤伴牵引型视网膜脱离和晶状体脱位1例(英文)显示文摘我们报告了1例疑似盲眼中自然消退型视网膜母细胞瘤病例。肿瘤稳定,无眼外扩散长达20a。其他症状包括:带状角膜病变,白瞳,晶状体脱位,视网膜肿块钙化和牵引型视网膜脱离。 | Visvaraja Subrayan Nadir Ali Mohamed Ali Dinesh Kumar Patel | 2009 | 国际眼科杂志2009，9，3： | 0 |
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