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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | E2A-PBX1 fusion in adult acute lymphoblastic leukem ia:biological and clinical features显示文摘 | Foa R Vitale A Mancini M | 2003 | British Journal of Hematology2003，，： | 1 |
| 3 | POEMS syndrome (or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol (Paris)2004，160，3： | 1 |
| 4 | Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 5 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007，21，6： | 1 |
| 6 | Prognostic impact of model for end-stage liver disease score in patients undergoing liver transplantation with suboptimal livers显示文摘 | Vitale A DAmico F Brolese A et at | 2007 | Transplant Proc2007，39，6： | 1 |
| 7 | Endoplasmic Retieulum Quality Control and theUnfolded Protein Response: Insights from Plants 显示文摘 | VITALE A BOSTON R S | 2008 | Blackwell Munks- gaard2008，9，： | 1 |
| 8 | Treatment of acute respiratory failure secondaryto pulmonary edema with bilevel positive airway pressure by nasal mask 显示文摘 | Lo Coco A Vitale G Marchese S | 2001 | Monaldi Arch Chest Dia2001，63，： | 1 |
| 9 | Discrepancy between clinical practice and standardized indications for an implantable loop recorder in patients with unexplained syncope显示文摘 | Vitale E Ungar A Maggi R | 2010 | Europace2010，12，10： | 1 |
| 10 | Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patientsenrolled in the GIMEMA LAL 0496 protocol 显示文摘 | Vitale A Guarini A Ariola C | 2006 | Blood2006，107，： | 1 |
| 11 | Clinical significance of alphafetoproteinmRNA in blood of patients with hepatocellular carcinoma显示文摘 | Cillo U Navaglia F Vitale A | 2004 | Clin Chim Acta2004，347，12： | 1 |
| 12 | E2A-PBX1 fusion in childhood acute lymphoblastic leulemia: biological and clinical features显示文摘 | Foa R Vitale A Mancini M | 2003 | Br J Haematol2003，120，： | 1 |
| 13 | Lysolecithin-induced demyelination in primates:preliminary in vivo study with MR and magnetization transfer显示文摘 | Dousset V Brochet B Vital A | 1995 | Am J Neuroradiol1995，16，： | 1 |
| 14 | POEMS syndrome(or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol(Paris)2004，160，3： | 1 |
| 15 | Recombinant human GAD65 accumulates to high levels in transgenic tobacco plants when expressed as an enzymatically inactive mutant 显示文摘 | Avesani L Vitale A Pedrazzini E | 2010 | Plant Biotechnol J2010，8，8： | 1 |
| 16 | Plasma levels of inflammatory C- reactive protein and interleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，9： | 1 |
| 17 | Plasma levels of inflammatory C-reactive protein and intcrleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvcstri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 18 | The binding protein associates with monomeric phaseolin显示文摘 | Vitale A Bielli A Ceriotti A | 1995 | Plant Physiol1995，107，： | 1 |
| 19 | Inhibition of tumor angigenesis by a single-chain antibody directed against vascular endothelial growth factor 显示文摘 | Vitaliti A | 2000 | Cancer Res2000，60，： | 1 |
| 20 | Effects of pulsed electric fields on microorganisms in orange juice using electric strengths of 30 and 50 kV/cm 显示文摘 | MCDONALD C J LLOYD S W VITALE M A | 2000 | J Food Sci2000，65，6： | 1 |
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